13期

最新文章

• Actuating superparamagnetic nanoparticle monolayers AI翻译
  作者：Esposito, Edward P.; Rios, Hector Manuel Lopez; de la Cruz, Monica Olvera; Jaeger, Heinrich M.
  作者单位：University of Chicago; University of Chicago; Northwestern University; Northwestern University; Northwestern University; Northwestern University
  摘要：Magnetically responsive, mechanically flexible microstructures are desirable for applications ranging from smart sensors to remote-controlled actuation for surgery or robotics. Embedding magnetic nanoparticles into a thin matrix of elastic material enables high flexibility while exploiting the magnetic response of the individual particles. However, in the ultrathin limit of such nanocomposite materials, the particles become too small to sustain a permanent dipole moment. This implies that now ...
• De novo discovery of a molecular glue-like macrocyclic peptide that induces MCL1 homodimerization AI翻译
  作者：Li, Fengwei; Zhang, Mengmeng; Liu, Chao; Cheng, Jie; Yang, Yawen; Peng, Xiangda; Li, Zhifeng; Cai, Wenfeng; Yu, Haipeng; Wu, Junjie; Guo, Yuyu; Geng, Hongkun; Fa, Yun; Zhang, Youming; Wu, Dalei; Yin, Yizhen
  作者单位：Shandong University; Chinese Academy of Sciences; Qingdao Institute of Bioenergy & Bioprocess Technology, CAS
  摘要：Macrocyclic peptides have emerged as promising drug candidates, filling the gap between small molecules and large biomolecules in drug discovery. The antiapoptotic protein myeloid cell leukemia 1 (MCL1) is crucial for numerous cancers, yet it presents challenges for selective targeting by traditional inhibitors. In this study, we identified a macrocyclic peptide, 5L1, that strongly binds to MCL1, with a dissociation constant (KD) of 7.1 nM. This peptide shows the potential to specifically inhi...
• Climate change impacts have potentially big repercussions for kids' education AI翻译
  作者：Sidik, Saima
• Magnetic suppression of quantum tunneling: Insights from Fefferman, Shapiro, and Weinstein AI翻译
  作者：Deift, Percy A.
• Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing AI翻译
  作者：Damianov, Andrey; Lin, Chia-; Zhang, Jian; Manley, James L.; Black, Douglas L.
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Columbia University
  摘要：Myelodysplastic syndromes and other cancers are often associated with mutations in the U2 snRNP protein SF3B1. Common SF3B1 mutations, including K700E, disrupt SF3B1 interaction with the protein SUGP1 and induce aberrant activation of alternative 3 ' splice sites (ss), presumably resulting from aberrant U2/branch site (BS) recognition by the mutant spliceosome. Here, we apply a method of U2 IP-seq to profile BS binding across the transcriptome of K562 leukemia cells carrying the SF3B1 K700E mu...
• Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688 AI翻译
  作者：Wang, Yan; Sun, Long; Fernandes, Luciana; Wang, Yu-Hsiu; Zou, Jing; Franklin, Samuel J.; Hu, Yanping; Palmer, Lee K.; Yeung, Jason; Barriga, Daniela; Russell, William K.; Moquin, Stephanie A.; Shi, Pei-Yong; Skepper, Colin; Xie, Xuping
  作者单位：University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; Novartis; Novartis USA; University of Texas System; University of Texas Medical Branch Galveston
  摘要：Dengue, caused by the dengue virus (DENV), presents a significant public health challenge with limited effective treatments. NITD-688 is a potent panserotype DENV inhibitor currently in Phase II clinical trials. However, its mechanism of action is not fully understood. Here, we present the molecular details of how NITD-688 inhibits DENV. NITD-688 binds directly to the nonstructural protein 4B (NS4B) with nano-molar affinities across all four DENV serotypes and specifically disrupts the interac...
• Expectation- dependent stimulus selectivity in the ventral visual cortical pathway AI翻译
  作者：Altavini, Tiago S.; Chen, Minggui; Astorga, Guadalupe; Yan, Yin; Li, Wu; Freiwald, Winrich; Gilbert, Charles D.
  作者单位：Rockefeller University; Beijing Normal University
  摘要：The hierarchical view of the ventral object recognition pathway is primarily based on feedforward mechanisms, starting from a fixed basis set of object primitives and ending on a representation of whole objects in the inferotemporal cortex. Here, we provide a different view. Rather than being a fixed labeled line for a specific feature, neurons are continually changing their stimulus selectivities on a moment-to-moment basis, as dictated by top-down influences of object expectation and percept...
• Reply to Deter- Wolf et al.: Laser- stimulated fluorescence of Chancay tattoos AI翻译
  作者：Kaye, Thomas G.; Bak, Judyta; Marcelo, Henry William; Pittman, Michael
  作者单位：Jagiellonian University; Chinese University of Hong Kong; University of London; University College London
• Avian cranial kinesis is the result of increased encephalization during the origin of birds AI翻译
  作者：Wilken, Alec T.; Sellers, Kaleb C.; Cost, Ian N.; Davis, Julian; Middleton, Kevin M.; Witmer, Lawrence M.; Holliday, Casey M.
  作者单位：University of Chicago; University of Missouri System; University of Missouri Columbia; University System of Ohio; Ohio University; University of Missouri System; University of Missouri Columbia
  摘要：The origin of birds represents a pivotal transition in vertebrate evolution, marked by significant changes in both brain size and feeding biomechanics. The evolution of the avian skull involved dramatic modifications, such as a segmented palate and the development of powered cranial kinesis in neognath birds. Powered kinesis, the ability to move parts of the skull independently, is considered a key innovation behind the dietary diversity and evolutionary success of birds. However, the processe...
• Bacteria on steroids AI翻译
  作者：Mrnjavac, Natalia; Martin, William F.
  作者单位：Heinrich Heine University Dusseldorf