13期

最新文章

• Allosteric mechanism in the distinctive coupling of Gq and Gs to the parathyroid hormone type 1 receptor AI翻译
  作者：Zhang, Xuan; Lee, Ji Young; Pacheco, Jonathan; Sutkeviciute, Ieva; Anitha, Anju Krishnan; Liu, Heng; Singh, Stephanie; Ventura, Carlos; Savransky, Sofya; Khatri, Ashok; Zhang, Cheng; Bahar, Ivet; Vilardaga, Jean-Pierre
  作者单位：Guangzhou Medical University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Stony Brook University Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; US Department of Veterans Affairs
  摘要：The mechanism determining the preferential stimulation of one heterotrimeric G protein signaling pathway over another by a ligand remains undetermined. By reporting the cryogenic electron microscopy (cryo-EM) structure of the parathyroid hormone (PTH) type 1 receptor (PTH1R) complexed with Gq and comparing its allosteric dynamics with that of PTH1R in complex with Gs, we uncover a mechanism underlying such preferences. We show that an allosteric coupling between the ligand PTH and the C-termin...
• Discovery and functional characterization of a bombesin- type neuropeptide signaling system in an invertebrate AI翻译
  作者：Huang, Weiling; Zhong, Xingxing; Zampronio, Cleidiane G.; Bottrill, Andrew R.; Jones, Kite G. E.; Tinoco, Ana B.; Guo, Lijin; Egertova, Michaela; Mirabeau, Olivier; Elphick, Maurice R.
  作者单位：Universidad de Cadiz; Universidad de Cadiz; University of London; Queen Mary University London; University of Warwick; South China Agricultural University; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Neuropeptide signaling systems are key regulators of physiological and behavioral processes in animals. However, the evolutionary history of some neuropeptides originally discovered in vertebrates is unknown. The peptide bombesin (BN) was first isolated from the skin of the toad Bombina bombina and subsequently BN-related neuropeptides have been identified in other chordates, including gastrin-releasing peptide (GRP) and neuromedin B (NMB) in mammals, and a GRP-like peptide in the cephalochord...
• Bayesian inference by visuomotor neurons in the prefrontal cortex AI翻译
  作者：Langlois, Thomas A.; Charlton, Julie A.; Goris, Robbe L. T.
  作者单位：Massachusetts Institute of Technology (MIT); Princeton University; University of Texas System; University of Texas Austin
  摘要：Perceptual judgments of the environment emerge from the concerted activity of neural populations in decision-making areas downstream of the sensory cortex. When the sensory input is ambiguous, perceptual judgments can be biased by prior expectations shaped by environmental regularities. These effects are examples of Bayesian inference, a reasoning method in which prior knowledge is leveraged to optimize uncertain decisions. However, it is not known how decision-making circuits combine sensory ...
• Supporting Information for Schmidt et al., Archaeological adhesives made from Podocarpus document innovative potential in the African Middle Stone Age (vol 119,e2209592119,2022) AI翻译
  作者：Schmidt, Patrick; Koch, Tabea J.; February, Edmund
• Linear Recursive Feature Machines provably recover low-rank matrices AI翻译
  作者：Radhakrishnan, Adityanarayanan; Belkin, Mikhail; Drusvyatskiy, Dmitriy
  作者单位：Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California San Diego; University of Washington; University of Washington Seattle
  摘要：A fundamental problem in machine learning is to understand how neural networks make accurate predictions, while seemingly bypassing the curse of dimensionality. A possible explanation is that common training algorithms for neural networks implicitly perform dimensionality reduction-a process called feature learning. Recent work [A. Radhakrishnan, D. Beaglehole, P. Pandit, M. Belkin, Science 383, 1461-1467 (2024).] posited that the effects of feature learning can be elicited from a classical st...
• Intravital imaging of translocated bacteria via fluorogenic labeling of gut microbiota in situ AI翻译
  作者：Fan, Xinqi; Zhou, Yingjun; Bai, Wenjuan; Li, Xue; Lin, Liyuan; Lin, Huibin; Yang, Ming; Yu, Xiaofei; Wang, Jing; Lin, Liang; Wang, Wei
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Fudan University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Shanghai Jiao Tong University
  摘要：The translocation of bacteria from intestinal tracts into blood vessels and distal organs plays pivotal roles in the pathogenesis of numerous severe diseases. Intravital monitoring of bacterial translocation, however, is not yet feasible, which greatly hinders us from comprehending this spatially and temporally dynamic process. Here we report an in vivo fluorogenic labeling method, which enables in situ imaging of mouse gut microbiota and real- time tracking of the translocated bacteria. By mi...
• Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species ( vol 122, e2417327122, 2025) AI翻译
  作者：Magesh, Shruthi; Schrope, Jonathan H.; Soto, Nayanna Mercado; Li, Chao; Hurley, Amanda I.; Huttenlocher, Anna; Beebe, David J.; Handelsman, Jo
• Using net- zero carbon debt to track climate overshoot responsibility AI翻译
  作者：Pelz, Setu; Ganti, Gaurav; Lamboll, Robin; Grant, Luke; Smith, Chris; Pachauri, Shonali; Rogelj, Joeri; Riahi, Keywan; Thiery, Wim; Gidden, Matthew J.
  作者单位：International Institute for Applied Systems Analysis (IIASA); Humboldt University of Berlin; Imperial College London; Imperial College London; Vrije Universiteit Brussel
  摘要：Current emissions trends will likely deplete a 1.5 degrees C consistent carbon budget around the year 2030, resulting in at least a temporary exceedance, or overshoot. To clarify responsibilities for this budget exceedance, we consider net- zero carbon debt, a forward- looking measure of the extent to which a party is expected to breach its fair share of the remaining budget by the time it achieves net- zero carbon emissions. We apply this measure to all vetted mitigation scenarios assessed in...
• Rolling vesicles: From confined rotational flows to surface-enabled motion AI翻译
  作者：Magrinya, Paula; Palacios-Alonso, Pablo; Llombart, Pablo; Delgado-Buscalioni, Rafael; Alexander-Katz, Alfredo; Arriaga, Laura R.; Aragones, Juan L.
  作者单位：Autonomous University of Madrid; Massachusetts Institute of Technology (MIT)
  摘要：Friction forces are essential for cell movement, yet they also trigger numerous active cellular responses, complicating their measurement in vivo. Here, we introduce a synthetic model designed to measure friction forces between biomimetic membranes and substrates. The model consists of a vesicle with precisely controlled properties, fabricated via microfluidics, encapsulating a single ferromagnetic particle that is magnetically driven to rotate. The rotation of the particle generates a confine...
• An atlas of protein phosphorylation dynamics during interferon signaling AI翻译
  作者：Busnadiego, Idoia; Lork, Marie; Fernbach, Sonja; Schiefer, Samira; Tsolakos, Nikos; Hale, Benjamin G.
  作者单位：University of Zurich; University of Copenhagen
  摘要：Interferons (IFNs, types I-III) have pleiotropic functions in promoting antiviral and antitumor responses, as well as in modulating inflammation. Dissecting the signaling mechanisms elicited by different IFNs is therefore critical to understand their phenotypes. Here, we use mass spectrometry to investigate the early temporal dynamics of cellular protein phosphorylation in a human lung epithelial cell-line as it responds to stimulation with IFN alpha 2, IFN beta, IFN omega, IFN gamma, or IFN l...