Expectation- dependent stimulus selectivity in the ventral visual cortical pathway

• 成果类型: Article
• 署名作者: Altavini, Tiago S.; Chen, Minggui; Astorga, Guadalupe; Yan, Yin; Li, Wu; Freiwald, Winrich; Gilbert, Charles D.
• 署名单位: Rockefeller University; Beijing Normal University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-14560
• DOI: 10.1073/pnas.2406684122
• 发表日期: 2025-04-01
• 关键词: inferior temporal cortex; contextual influences; working-memory; RECOGNITION; responses; neurons; shape; face; v1; suppression

摘要

The hierarchical view of the ventral object recognition pathway is primarily based on feedforward mechanisms, starting from a fixed basis set of object primitives and ending on a representation of whole objects in the inferotemporal cortex. Here, we provide a different view. Rather than being a fixed labeled line for a specific feature, neurons are continually changing their stimulus selectivities on a moment-to-moment basis, as dictated by top-down influences of object expectation and perceptual task. Here, we also derive the selectivity for stimulus features from an ethologically curated stimulus set, based on a delayed match-to-sample task, that finds components that are informative for object recognition in addition to full objects, though the top-down effects were seen for both informative and uninformative components. Cortical areas responding to these stimuli were identified with functional MRI in order to guide placement of chronically implanted electrode arrays.