13期

最新文章

• Large language models for identifying social determinants of health AI翻译
  作者：Wang, Yu
  作者单位：Fudan University
• Systematic changes in circumpolar dust transport to the Subantarctic Pacific Ocean over the last two glacial cycles (vol 119, e2206085119, 2022) AI翻译
  作者：Struve, Torben; Longman, Jack; Zander, Martin; Lamy, Frank; Winckler, Gisela; Pahnke, Katharina
• The visuomotor transformations underlying target-directed behavior AI翻译
  作者：Zhao, Peixiong; Tong, Yuxin; Lazarte, Ivan P.; Khan, Biswadeep; Tian, Guangnan; Chen, Kenny K. Y.; Lam, Thomas K. C.; Hu, Yu; Semmelhack, Julie L.
  作者单位：Hong Kong University of Science & Technology; University of Oxford; Hong Kong University of Science & Technology; Stanford Medicine; Stanford University; Hong Kong University of Science & Technology; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Hong Kong University of Science & Technology
  摘要：The visual system can process diverse stimuli and make the decision to execute appropriate behaviors, but it remains unclear where and how this transformation takes place. Innate visually evoked behaviors such as hunting, freezing, and escape are thought to be deeply conserved, and have been described in a range of species from insects to humans. We found that zebrafish larvae would respond to predator- like visual stimuli with immobility and bradycardia, both hallmarks of freezing, in a head-...
• In situ cavitation bubble manometry reveals a lack of light- activated guard cell turgor modulation in bryophytes AI翻译
  作者：Brodersen, Craig R.; Brodribb, Tim J.; Hochberg, Uri; Holbrook, N. Michele; Mcadam, Scott A. M.; Zailaa, Joseph; Huggett, Brett A.; Marmottant, Philippe
  作者单位：Yale University; University of Tasmania; Volcani Institute of Agricultural Research; Harvard University; Purdue University System; Purdue University; Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; CNRS - Institute of Physics (INP); Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS)
  摘要：Diversification of plant hydraulic architecture and stomatal function coincides with radical changes in the Earth's atmosphere over the past 400 my. Due to shared stomatal anatomywith the earliest land plants, bryophyte stomatal behavior may provide insights into the evolution of stomatal function, but significant uncertainty remains due to technical limitations of measuring guard cell turgor pressure in situ. Here, we introduce a method for monitoring cell turgor pressure by nucleating microb...
• Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing AI翻译
  作者：Damianov, Andrey; Lin, Chia-; Zhang, Jian; Manley, James L.; Black, Douglas L.
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Columbia University
  摘要：Myelodysplastic syndromes and other cancers are often associated with mutations in the U2 snRNP protein SF3B1. Common SF3B1 mutations, including K700E, disrupt SF3B1 interaction with the protein SUGP1 and induce aberrant activation of alternative 3 ' splice sites (ss), presumably resulting from aberrant U2/branch site (BS) recognition by the mutant spliceosome. Here, we apply a method of U2 IP-seq to profile BS binding across the transcriptome of K562 leukemia cells carrying the SF3B1 K700E mu...
• Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688 AI翻译
  作者：Wang, Yan; Sun, Long; Fernandes, Luciana; Wang, Yu-Hsiu; Zou, Jing; Franklin, Samuel J.; Hu, Yanping; Palmer, Lee K.; Yeung, Jason; Barriga, Daniela; Russell, William K.; Moquin, Stephanie A.; Shi, Pei-Yong; Skepper, Colin; Xie, Xuping
  作者单位：University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; Novartis; Novartis USA; University of Texas System; University of Texas Medical Branch Galveston
  摘要：Dengue, caused by the dengue virus (DENV), presents a significant public health challenge with limited effective treatments. NITD-688 is a potent panserotype DENV inhibitor currently in Phase II clinical trials. However, its mechanism of action is not fully understood. Here, we present the molecular details of how NITD-688 inhibits DENV. NITD-688 binds directly to the nonstructural protein 4B (NS4B) with nano-molar affinities across all four DENV serotypes and specifically disrupts the interac...
• Explaining human motor coordination via the synergy expansion hypothesis AI翻译
  作者：Tessari, Federico; West Jr, A. Michael; Hogan, Neville
  作者单位：Massachusetts Institute of Technology (MIT); Johns Hopkins University; Massachusetts Institute of Technology (MIT)
  摘要：The search for an answer to Bernstein's degrees of freedom problem has propelled a large portion of research studies in human motor control over the past six decades. Different theories have been developed to explain how humans might use their incredibly complex neuro-musculo-skeletal system with astonishing ease. Among these theories, motor synergies appeared as one possible explanation. In this work, the authors investigate the nature and role of synergies and propose a theoretical framework...
• Cholesterol- dependent enzyme activity of human TSPO1 AI翻译
  作者：Qiu, Weihua; Trinh, Thi Kim Hoang; Catalano, Claudio; Mehta, Akul; Desai, Umesh R.; Kellogg, Glen E.; Hendrickson, Wayne A.; Guo, Youzhong
  作者单位：Virginia Commonwealth University; Virginia Commonwealth University; Columbia University; Columbia University
  摘要：The amino acid sequence of the tryptophan- rich sensory proteins (TSPO) is substantially conserved throughout all kingdoms of life. Human mitochondrial TSPO1 (HsTSPO1) binds to porphyrins and steroids, although its interactions with these molecules remains unknown. HsTSPO1 is associated with numerous physiological and pathological disorders, but the underlying molecular mechanisms are unknown. Here, we disclose the finding of human mitochondrial TSPO as a cholesterol- dependent protoporphyrin ...
• Prediction of phase-separation propensities of disordered proteins from sequence AI翻译
  作者：von Buelow, Soeren; Tesei, Giulio; Kamalzaidi, Fatima; Mittag, Tanja; Lindorff-Larsen, Kresten
  作者单位：University of Copenhagen; St Jude Children's Research Hospital
  摘要：Phase separation is one possible mechanism governing the selective cellular enrichment of biomolecular constituents for processes such as transcriptional activation, mRNA regulation, and immune signaling. Phase separation is mediated by multivalent interactions of macromolecules including intrinsically disordered proteins and regions (IDRs). Despite considerable advances in experiments, theory, and simulations, the prediction of the thermodynamics of IDR phase behavior remains challenging. We ...
• Supporting Information for Walters et al., Identification of FSH- regulated and estrous stage-specific transcriptional networks in mouse ovaries (vol 112, e2411977122,2025) AI翻译
  作者：Walters, Kathryn; Baldwin, Amber; Liu, Zhenghui; Larsen, Mark; Mukherjee, Neelanjan; Kumar, T. Rajendra