13期

最新文章

• Cytoplasmic Mg2+supersedes carbon source preference to dictate Salmonella metabolism AI翻译
  作者：Pokorzynski, Nick D.; Jones, Katarina A.; Campagna, Shawn R.; Groisman, Eduardo A.
  作者单位：Yale University; University of Tennessee System; University of Tennessee Knoxville
  摘要：Glucose is the preferred carbon source of most studied microorganisms. However, we now report that glucose loses preferred status when the intracellular pathogen Salmonella enterica serovar Typhimurium experiences cytoplasmic magnesium (Mg2+) starvation. We establish that this infection-relevant stress drastically reduces synthesis of cyclic adenosine monophosphate (cAMP), the allosteric activator of the cAMP receptor protein (CRP), master regulator of carbon utilization. The resulting reducti...
• Striking the balance: Complexity, simplicity, and credibility in mathematical biology AI翻译
  作者：Rodero, Cristobal; Niederer, Steven A.
  作者单位：Imperial College London; Alan Turing Institute
• Climate change amplifies neurotoxic methylmercury threat to Asian fish consumers AI翻译
  作者：Wu, Mengjie; Wu, Xinda; Lopez, Alfonso; Blanchfield, Paul J.; Ren, Hongqiang; Zhong, Huan
  作者单位：Nanjing University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC)
  摘要：Climate change is intricately influencing the accumulation of neurotoxic methylmercury (MeHg) in human food webs, potentially leading to uneven exposure risks across regions. Here, we reveal that climate change will elevate MeHg risks in China, with implications for regional inequalities in Asia through a climate- mercury- food- health nexus. Using a compiled fish mercury dataset from 13,000 samples and machine learning, we find that freshwater wild fish-an essential component of the Asian die...
• Competition response of cloud supersaturation explains diminished Twomey effect for smoky aerosol in the tropical Atlantic AI翻译
  作者：Dedrick, Jeramy L.; Pelayo, Christian N.; Russell, Lynn M.; Lubin, Dan; Muelmenstaedt, Johannes; Miller, Mark
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Rutgers University System; Rutgers University New Brunswick
  摘要：The Twomey effect brightens clouds by increasing aerosol concentrations, which activates more droplets and decreases cloud supersaturation in response to more competition for water vapor. To quantify this competition response, we used marine low cloud observations in clean and smoky conditions at Ascension Island in the tropical South Atlantic during the Layered Aerosol Smoke Interactions with Cloud (LASIC) campaign. These observations show similar increases in droplet number for increased acc...
• The emergence of eukaryotes as an evolutionary algorithmic phase transition AI翻译
  作者：Muro, Enrique M.; Ballesteros, Fernando J.; Luque, Bartolo; Bascompte, Jordi
  作者单位：Johannes Gutenberg University of Mainz; University of Valencia; Universidad Politecnica de Madrid; University of Zurich
  摘要：The origin of eukaryotes represents one of the most significant events in evolution since it allowed the posterior emergence of multicellular organisms. Yet, it remains unclear how existing regulatory mechanisms of gene activity were transformed to allow this increase in complexity. Here, we address this question by analyzing the length distribution of proteins and their corresponding genes for 6,519 species across the tree of life. We find a scale-invariant relationship between gene mean leng...
• Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes AI翻译
  作者：Sierant, Michael C.; Jin, Sheng Chih; Bilguvar, Kaya; Morton, Sarah U.; Dong, Weilai; Jiang, Wei; Lu, Ziyu; Li, Boyang; Lopez-Giraldez, Francesc; Tikhonova, Irina; Zeng, Xue; Lu, Qiongshi; Choi, Jungmin; Zhang, Junhui; Nelson-Williams, Carol; Knight, James R.; Zhao, Hongyu; Cao, Junyue; Mane, Shrikant; Sedore, Stanley C.; Gruber, Peter J.; Lek, Monkol; Goldmuntz, Elizabeth; Deanfield, John; Giardini, Alessandro; Mital, Seema; Russell, Mark; Gaynor, J. William; King, Eileen; Wagner, Michael; Srivastava, Deepak; Shen, Yufeng; Bernstein, Daniel; Porter Jr, George A.; Newburger, Jane W.; Seidman, Jonathan G.; Roberts, Amy E.; Yandell, Mark; Yost, H. Joseph; Tristani-Firouzi, Martin; Kim, Richard; Chung, Wendy K.; Gelb, Bruce D.; Seidman, Christine E.; Brueckner, Martina; Lifton, Richard P.
  作者单位：Yale University; Rockefeller University; Washington University (WUSTL); Washington University (WUSTL); Yale University; Yale University; Yale University; Acibadem University; Acibadem University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Yale University; Rockefeller University; University of Wisconsin System; University of Wisconsin Madison; Korea University; Korea University Medicine (KU Medicine); Yale University; Michigan State University; Michigan State University College of Human Medicine; Yale University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of London; University College London; University of London; University College London; Great Ormond Street Hospital for Children NHS Foundation Trust; University of Toronto; Hospital for Sick Children (SickKids); University of Michigan System; University of Michigan; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; Columbia University; NewYork-Presbyterian Hospital; Columbia University; NewYork-Presbyterian Hospital; Stanford University; University of Rochester; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Utah System of Higher Education; University of Utah; Catholic University of America; Utah System of Higher Education; University of Utah; Cedars Sinai Medical Center; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Columbia University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute
  摘要：Congenital heart disease (CHD) is a leading cause of infant mortality. We analyzed de novo mutations (DNMs) and very rare transmitted/unphased damaging variants in 248 prespecified genes in 11,555 CHD probands. The results identified 60 genes with a significant burden of heterozygous damaging variants. Variants in these genes accounted for CHD in 10.1% of probands with similar contributions from de novo and transmitted variants in parent-offspring trios that showed incomplete penetrance. DNMs ...
• Control of circadian muscle glucose metabolism through the BMAL1-HIF axis in obesity AI翻译
  作者：Chaikin, Claire A.; Thakkar, Abhishek, V; Steffeck, Adam W. T.; Pfrender, Eric M.; Hung, Kaitlyn; Zhu, Pei; Waldeck, Nathan J.; Nozawa, Rino; Song, Weimin; Futtner, Christopher R.; Quattrocelli, Mattia; Bass, Joseph; Ben-Sahra, Issam; Peek, Clara B.
  作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati
  摘要：Disruptions of circadian rhythms are widespread in modern society and lead to accelerated and worsened symptoms of metabolic syndrome. In healthy mice, the circadian clock factor BMAL1 is required for skeletal muscle function and metabolism. However, the importance of muscle BMAL1 in the development of metabolic diseases, such as diet- induced obesity (DIO), remains unclear. Here, we demonstrate that skeletal muscle-specific BMAL1- deficient mice exhibit worsened glucose tolerance upon high- f...
• Targeted degradation of α- Synuclein using an evolved botulinum toxin protease AI翻译
  作者：Sondermann, Philipp; Diercks, Christian S.; Rong, Cynthia; Schultz, Peter G.
  作者单位：Scripps Research Institute; Scripps Research Institute
  摘要：There is considerable interest in the targeted degradation of proteins implicated in human disease. The use of sequence-specific proteases for this purpose is severely limited by the difficulty in engineering the numerous enzyme-substrate interactions required to yield highly selective proteases while maintaining catalytic activity. Herein, we report a strategy to evolve a protease for the programmed degradation of alpha- Synuclein, a pre-synaptic protein closely linked to Parkinson's disease....
• Xylem embolism refilling revealed in stems of a weedy grass AI翻译
  作者：Stewart, Jared J.; Allen, Brendan S.; Polutchko, Stephanie K.; Ocheltree, Troy W.; Gleason, Sean M.
  作者单位：United States Department of Agriculture (USDA); University of Colorado System; University of Colorado Boulder; Colorado State University System; Colorado State University Fort Collins
  摘要：Plant hydraulic dysfunction by embolism formation can impair photosynthesis, growth, and reproduction and, in severe cases, lead to death. Embolism reversal, or refilling, is a hypothesized adaptive process in which xylem functionality is rapidly and sustainably restored. This study investigated xylem embolism refilling during recovery from severe drought stress using entirely noninvasive measurements of the same plants. These results were considered in relation to functional traits to address...
• Central TYK2 inhibition identifies TYK2 as a key neuroimmune modulator AI翻译
  作者：Molitor, Tyler P.; Hayashi, Genki; Lin, Mei-Yao; Dunn, Carissa J.; Peterson, Nathan G.; Poston, Robert G.; Kurnellas, Michael P.; Traver, David A.; Patel, Seona; Akgungor, Zeynep; Leonardi, Virginia; Lewis, Colizel; Segales, Joshua S.; Bennett, Dylan S.; Truong, Anh P.; Dani, Manjari; Naphade, Swati; Wong, Jamie K.; McDermott, Annie E.; Kovalev, Sarah M.; Ciaccio, Gillian L.; Sadiq, Saud A.; Pei, Zhonghua; Wood, Stephen; Rassoulpour, Arash
  摘要：GWAS have identified tyrosine kinase 2 (TYK2) variants in multiple inflammatory disorders, specifically a protective hypomorphic TYK2 allele (P1104A) in multiple sclerosis (MS). Impaired TYK2 signaling within the central nervous system (CNS) may impart the protective effects of TYK2 P1104A allele in MS. We deployed brain- penetrant TYK2 inhibitors (cTYK2i) alongside the peripherally restricted TYK2 inhibitor (pTYK2i; BMS- 986165) to untangle the contributions of central TYK2 inhibition in dive...