13期

最新文章

• Adaptive ATP-induced molecular condensation in membranized protocells AI翻译
  作者：Mukwaya, Vincent; Yu, Xiaolei; Yang, Shuo; Mann, Stephen; Dou, Hongjing
  作者单位：Shanghai Jiao Tong University; University of Bristol; University of Bristol; University of Bristol
  摘要：Liquid-liquid phase separation (LLPS) has been achieved in various cytomimetic (protocell) models, but controlling molecular condensation using noninert crowders to systematically alter protocell function remains challenging. Intracellular ATP levels influence protein-protein interactions, and dysregulation of ATP can alter cellular crowding dynamics, thereby disrupting the normal formation or dissolution of condensates. Here, we develop a membranized protocell model capable of endogenous LLPS...
• Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms in Mycobacterium tuberculosis (vol 122, e2419813122, 2025) AI翻译
  作者：Quach, Diana; Sharp, Marc; Ahmed, Sara; Ames, Lauren; Bhagwat, Amala; Deshpande, Aditi; Parish, Tanya; Pogliano, Joe; Sugie, Joseph
• Bridging the human-AI knowledge gap through concept discovery and transfer in AlphaZero AI翻译
  作者：Schut, Lisa; Tomasev, Nenad; McGrath, Thomas; Hassabis, Demis; Paquet, Ulrich; Kim, Been
  作者单位：University of Oxford; Alphabet Inc.; DeepMind; Google Incorporated; Alphabet Inc.; DeepMind
  摘要：AI systems have attained superhuman performance across various domains. If the hidden knowledge encoded in these highly capable systems can be leveraged, human knowledge and performance can be advanced. Yet, this internal knowledge is difficult to extract. Due to the vast space of possible internal representations, searching for meaningful new conceptual knowledge can be like finding a needle in a haystack. Here, we introduce a method that extracts new chess concepts from AlphaZero, an AI syst...
• How circuits for habits are formed within the basal ganglia AI翻译
  作者：Grillner, Sten
  作者单位：Karolinska Institutet
  摘要：Recent findings show that stereotyped movement sequences (habits) need the cortex in the learning phase, but after learning, the cortex can be inactivated, and the movement still be performed flawlessly. The motor program is dependent on the sensorimotor part of the dorsolateral striatum (DLS) and on synaptic plasticity in the thalamostriatal synapses. New findings from several laboratories have revealed a highly precise spatially interactive organization within the basal ganglia [DLS, substan...
• Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia (vol 122, e2423169122, 2025) AI翻译
  作者：Wang, Jun-Yu; Gui, Tuan-Tuan; Jiao, Bo; Liu, Xuan; Ma, Xiao-Lin; Wang, Cheng; Qiao, Jing; Liu, Wei-Yang; Peng, Li-Jun; Ren, Jia-Yi; Zhu, Yong-Mei; Weng, Xiang-Qin; Wang, Chao; Zhang, Qian-Qian; Song, Gao-Xian; Dai, Yu-Ting; Wang, Zhen-Yi; Lv, Gang; Gao, Chen-Xu; Qiao, Niu; Zhang, Ming; Tan, Yun; Liu, Yuan-Fang; Wang, Sheng-Yue; Hou, Jian; Jing, Duo-Hui; Lyu, An-Kang; Mi, Jian-Qing; Chen, Zhu; Chen, Wen-Lian; Yin, Tong; Fang, Hai; Wang, Jin; Chen, Sai-Juan
• Belief in belief: Even atheists in secular countries show intuitive preferences favoring religious belief AI翻译
  作者：Gervais, Will M.; McKay, Ryan T.; Brown-Iannuzzi, Jazmin L.; Ross, Robert M.; Pennycook, Gordon; Jong, Jonathan; Lanman, Jonathan A.
  作者单位：Brunel University; University of London; Royal Holloway University London; University of Virginia; Macquarie University; Cornell University; Coventry University; Queens University Belfast
  摘要：We find evidence of belief in belief-intuitive preferences for religious belief over atheism, even among atheist participants-across eight comparatively secular countries. Religion is a cross-cultural human universal, yet explicit markers of religiosity have rapidly waned in large parts of the world in recent decades. We explored whether intuitive religious influence lingers, even among nonbelievers in largely secular societies. We adapted a classic experimental philosophy task to test for thi...
• A national megastudy shows that email nudges to elementary school teachers boost student math achievement, particularly when personalized AI翻译
  作者：Duckworth, Angela L.; Ko, Ahra; Milkman, Katherine L.; Kay, Joseph S.; Dimant, Eugen; Gromet, Dena M.; Halpern, Aden; Jung, Youngwoo; Paxson, Madeline K.; Zumaran, Ramon A. Silvera; Berman, Ron; Brody, Ilana; Camerer, Colin F.; Canning, Elizabeth A.; Dai, Hengchen; Gallo, Marcos; Hershfield, Hal E.; Hilchey, Matthew D.; Kalil, Ariel; Kroeper, Kathryn M.; Lyon, Amy; Manning, Benjamin S.; Mazar, Nina; Michelini, Michelle; Mayer, Susan E.; Murphy, Mary C.; Oreopoulos, Philip; Parker, Sharon E.; Rondina, Renante; Soman, Dilip; van den Bulte, Christophe
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Pennsylvania; University of California System; University of California Los Angeles; California Institute of Technology; Washington State University; Sacred Heart University; Boston University; University of Toronto
  摘要：In response to the alarming recent decline in US math achievement, we conducted a national megastudy in which 140,461 elementary school teachers who collectively taught 2,992,027 students were randomly assigned to receive a variety of behaviorally informed email nudges aimed at improving students' progress in math. Specifically, we partnered with the nonprofit educational platform Zearn Math to compare the impact of 15 different interventions with a reminder-only megastudy control condition. A...
• Nanosilica supplementation in tomato increases oviposition on stems and caterpillar mortality in the tomato pinworm AI翻译
  作者：Fiaboe, Kokou R.; Khamis, Fathiya M.; Cheseto, Xavier; Yusuf, Abdullahi A.; Torto, Baldwyn
  作者单位：International Centre of Insect Physiology & Ecology (ICIPE); University of Pretoria
  摘要：Silicon-induced responses play a key role in plant defense against herbivory, though the underlying mechanisms remain underexplored. In this study, we examined how mesoporous silica nanoparticles (MSNs) affect tomato (Solanum lycopersicum) defense against an invasive and highly destructive lepidopteran herbivore, the tomato pinworm (TPW), Phthorimaea absoluta. In tomato plants supplemented with MSN, prior exposure to TPW oviposition shifted subsequent egg-laying from a preference for leaves to...
• Modulation of host gene expression by the zinc finger antiviral protein AI翻译
  作者：Goncalves-Carneiro, Daniel; Mastrocola, Emily; Lei, Xiao; Bieniasz, Paul D.
  作者单位：Imperial College London; Rockefeller University; Howard Hughes Medical Institute; Rockefeller University
  摘要：The zinc finger antiviral protein (ZAP) depletes nonself RNAs through recognition of their elevated CpG dinucleotide content. CpG dinucleotides are sparse in most endogenous mammalian mRNAs, but a subset might potentially be modulated by ZAP. While CpG frequency alone is insufficient to predict ZAP- regulation, we developed an algorithm using experimentally determined compositional features to predict which endogenous mRNAs may be ZAP- regulated. Using ZAP- knockout mice, we demonstrate that l...
• Potassium- sensitive loss of muscle force in the setting of reduced inward rectifier K+ current: Implications for Andersen-Tawil syndrome AI翻译
  作者：Elia, Nathaniel; Quinonez, Marbella; Wu, Fenfen; Mokhonova, Ekaterina; DiFranco, Marino; Spencer, Melissa J.; Cannon, Stephen C.
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：Andersen-Tawil syndrome (ATS) is an ion channelopathy with variable penetrance for the triad of periodic paralysis, arrhythmia, and dysmorphia. Dominant-negative mutations of KCNJ2 encoding the Kir2.1 potassium channel subunit are found in 60% of ATS families. As with most channelopathies, episodic attacks in ATS are frequently triggered by environmental stresses: exercise for periodic paralysis or stress with adrenergic stimulation for arrhythmia. Fluctuations in K+, either low or high, are p...