13期

最新文章

• Correction for Ganguli et al., A culture- free biphasic approach for sensitive and rapid detection of pathogens in dried whole- blood matrix AI翻译
  作者：Ganguli, Anurup; Lim, Jongwon; Mostafa, Ariana; Saavedra, Carlos; Rayabharam, Archith; Aluru, Narayana R.; Wester, Matthew; White, Karen C.; Kumar, James; McGuffin, Reubin; Frederick, Ann; Valera, Enrique; Bashir, Rashid
• The FBXW7-KMT 2 axis in cancer- associated fibroblasts controls tumor growth via an epigenetic- paracrine mechanism AI翻译
  作者：Yin, Lu; Zhang, Jiagui; Zhu, Zhipeng; Peng, Xiaojuan; Lan, Huiyin; Ayoub, Alex; Tan, Mingjia; Zhou, Bo; He, Yaohui; Wang, Siyuan; Lu, Yan; Liu, Wen; Xiong, Xiufang; Huang, Jing; Dou, Yali; Mao, Fengbiao; Sun, Yi
  作者单位：Zhejiang University; Zhejiang University; Shanghai Jiao Tong University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Xiamen University; Zhejiang University; Zhejiang University; Zhejiang University; University of Southern California; University of Southern California; Zhejiang University; Zhejiang University
  摘要：F-box and WD repeat domain-containing 7 (FBXW7) is a tumor suppressor that targets various oncoproteins for degradation, but its role in modulating cancer-associated fibroblasts (CAFs) in the tumor microenvironment remains elusive. Here, we report that FBXW7 expression is gradually downregulated in CAFs during the progression of human pancreatic and lung cancers. Mechanically, FBXW7 inhibits histone lysine methyltransferase 2 (KMT2) methyltransferase activity via retinoblastoma binding protein...
• Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase AI翻译
  作者：Ariyani, Winda; Yoshikawa, Chiharu; Tsuneoka, Haruka; Amano, Izuki; Imayoshi, Itaru; Ichinose, Hiroshi; Sumi-Ichinose, Chiho; Koibuchi, Noriyuki; Kitamura, Tadahiro; Kohno, Daisuke
  作者单位：Gunma University; Gunma University; Kyoto University; Kyoto University; Kyoto University; Fujita Health University
  摘要：Feeding behavior is controlled by various neural networks in the brain that are involved in different feeding phases: Food procurement, consumption, and termination. However, the specific neural circuits controlling the food consumption phase remain poorly understood. Here, we investigated the roles of dopaminergic neurons in the paraventricular nucleus of the hypothalamus (PVH) in the feeding behavior in mice. Our results indicated that the PVH dopaminergic neurons were critical for extending...
• Social control drove ant evolution AI翻译
  作者：Linksvayer, Timothy A.
  作者单位：Arizona State University; Arizona State University-Tempe
• Explaining human motor coordination via the synergy expansion hypothesis AI翻译
  作者：Tessari, Federico; West Jr, A. Michael; Hogan, Neville
  作者单位：Massachusetts Institute of Technology (MIT); Johns Hopkins University; Massachusetts Institute of Technology (MIT)
  摘要：The search for an answer to Bernstein's degrees of freedom problem has propelled a large portion of research studies in human motor control over the past six decades. Different theories have been developed to explain how humans might use their incredibly complex neuro-musculo-skeletal system with astonishing ease. Among these theories, motor synergies appeared as one possible explanation. In this work, the authors investigate the nature and role of synergies and propose a theoretical framework...
• Cholesterol- dependent enzyme activity of human TSPO1 AI翻译
  作者：Qiu, Weihua; Trinh, Thi Kim Hoang; Catalano, Claudio; Mehta, Akul; Desai, Umesh R.; Kellogg, Glen E.; Hendrickson, Wayne A.; Guo, Youzhong
  作者单位：Virginia Commonwealth University; Virginia Commonwealth University; Columbia University; Columbia University
  摘要：The amino acid sequence of the tryptophan- rich sensory proteins (TSPO) is substantially conserved throughout all kingdoms of life. Human mitochondrial TSPO1 (HsTSPO1) binds to porphyrins and steroids, although its interactions with these molecules remains unknown. HsTSPO1 is associated with numerous physiological and pathological disorders, but the underlying molecular mechanisms are unknown. Here, we disclose the finding of human mitochondrial TSPO as a cholesterol- dependent protoporphyrin ...
• Prediction of phase-separation propensities of disordered proteins from sequence AI翻译
  作者：von Buelow, Soeren; Tesei, Giulio; Kamalzaidi, Fatima; Mittag, Tanja; Lindorff-Larsen, Kresten
  作者单位：University of Copenhagen; St Jude Children's Research Hospital
  摘要：Phase separation is one possible mechanism governing the selective cellular enrichment of biomolecular constituents for processes such as transcriptional activation, mRNA regulation, and immune signaling. Phase separation is mediated by multivalent interactions of macromolecules including intrinsically disordered proteins and regions (IDRs). Despite considerable advances in experiments, theory, and simulations, the prediction of the thermodynamics of IDR phase behavior remains challenging. We ...
• Supporting Information for Walters et al., Identification of FSH- regulated and estrous stage-specific transcriptional networks in mouse ovaries (vol 112, e2411977122,2025) AI翻译
  作者：Walters, Kathryn; Baldwin, Amber; Liu, Zhenghui; Larsen, Mark; Mukherjee, Neelanjan; Kumar, T. Rajendra
• Systematic changes in circumpolar dust transport to the Subantarctic Pacific Ocean over the last two glacial cycles (vol 119, e2206085119, 2022) AI翻译
  作者：Struve, Torben; Longman, Jack; Zander, Martin; Lamy, Frank; Winckler, Gisela; Pahnke, Katharina
• Superficial auditory (dis)fluency biases higher- level social judgment AI翻译
  作者：Terrill, Robert Walter-; Ongchoco, Joan Danielle K.; Scholl, Brian J.
  作者单位：Yale University; University of British Columbia; Yale University
  摘要：When talking to other people, we naturally form impressions based not only on what they say but also on how they say it-e.g., how confident they sound. In modern life, however, the sounds of voices are often determined not only by intrinsic qualities (such as vocal anatomy) but also by extrinsic properties (such as videoconferencing microphone quality). Here, we show that such superficial auditory properties can have surprisingly deep consequences for higher- level social judgments. Listeners ...