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作者：Cardenas, Michael A.; Le, Ryan P.; Champ, Tess M.; O'Neill, Derek; Fuglevand, Andrew J.; Gothard, Katalin M.
作者单位：University of Arizona
摘要：Several influential theories have proposed that interoceptive signals, sent from the body to the brain, contribute to neural processes that coordinate complex behaviors. We altered the physiological state of the body using compounds that have minimal effect on the brain and evaluated their effect on decision making in rhesus monkeys. We used glycopyrrolate, a nonspecific muscarinic (parasympathetic) antagonist, and isoproterenol, a beta-1/2 (sympathetic) agonist, to create a sympathetic-domina...
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作者：Stransky, Laura A.; Gao, Wenhua; Schmidt, Laura S.; Bi, Kevin; Ricketts, Christopher J.; Ramesh, Vijyendra; James, Amy; Difilippantonio, Simone; Ileva, Lilia; Kalen, Joseph D.; Karim, Baktiar; Jeon, Albert; Morgan, Tamara; Warner, Andrew C.; Turan, Sevilay; Unite, Joanne; Tran, Bao; Choudhari, Sulbha; Zhao, Yongmei; Linn, Douglas E.; Yun, Changhong; Dhandapani, Sripriya; Parab, Vaishali; Pinheiro, Elaine M.; Morris, Nicole; He, Lixia; Vigeant, Sean M.; Pignon, Jean-Christophe; Sticco-Ivins, Maura; Signoretti, Sabina; Van Allen, Eliezer M.; Linehan, W. Marston; Kaelin Jr, William G.
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作者：Wolf, Aaron Deter-; Robitaille, Benoit; Krutak, Lars
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作者：Li, Zixuan; Moir, Camilla M.; McKee, Nathan J.; Lee-Wong, Eric; Baumbach, Ryan E.; Maple, M. Brian; Liu, Ying
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California San Diego; University of California System; University of California San Diego; State University System of Florida; Florida State University; State University System of Florida; Florida State University
摘要：Symmetry properties of the order parameter are among the most fundamental characteristics of a superconductor. UTe2, which was found to feature an exceedingly large upper critical field and striking reentrant behavior at low temperatures, is widely believed to possess a spin-triplet pairing symmetry. However, unambiguous evidence for such a pairing symmetry is still lacking, especially at zero and low magnetic fields. The presence of an inversion crystalline symmetry in UTe2 requires that, if ...
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作者：Ogawa, Takumi; Koyama, Shuji; Omori, Toshihiro; Kikuchi, Kenji; de Maleprade, Helene; Goldstein, Raymond E.; Ishikawa, Takuji
作者单位：Tohoku University; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; University of Cambridge; Tohoku University
摘要：Sponges, the basalmost members of the animal kingdom, exhibit a range of complex architectures in which microfluidic channels connect multitudes of spherical chambers lined with choanocytes, flagellated filter-feeding cells. Choanocyte chambers can possess scores or even hundreds of such cells, which drive complex flows entering through porous walls and exiting into the sponge channels. One of the mysteries of the choanocyte chamber is its spherical shape, as it seems inappropriate for inducin...
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作者：Zhang, Xin; Wu, Jingyi; Min, Zhenzhen; Wang, Jiamao; Hong, Xin; Pei, Xinkai; Rao, Zihe; Xu, Xiaoling
作者单位：Hangzhou Normal University; Hangzhou Normal University; Tsinghua University
摘要：F-type ATP synthase (F1FO) catalyzes proton motive force-driven ATP synthesis in mitochondria, chloroplasts, and bacteria. Different from the mitochondrial and bacterial enzymes, F1FO from photosynthetic organisms have evolved diverse structural and mechanistic details to adapt to the light-dependent reactions. Although complete structure of chloroplast F1FO has been reported, no high-resolution structure of an F1FO from photosynthetic bacteria has been available. Here, we report cryo-EM struc...
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作者：Close, Roger Adam; Reijenga, Bouwe Rutger
作者单位：University of Oxford
摘要：Mass extinctions are rare but catastrophic events that profoundly disrupt biodiversity. Widely accepted consequences of mass extinctions, such as biodiversity loss and the appearance of temporary disaster taxa, imply that species-area relationships (SARs, or how biodiversity scales with area) should change dramatically across these events: Specifically, both the slope (the rate of accumulation of new species with increasing area) and intercept (the density of species at local scales) of the po...
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作者：Tao, Lei; Zhang, Hanrui; Shah, Sameep Rajubhai; Yang, Xixian; Lai, Jianwei; Guo, Yanjun; Russell, Joshua A.; Xia, Dawei; Min, Jungki; Huang, Weibo; Shi, Chenguang; Liang, Zhaohui; Yu, Deyang; Hwang, Sooyeon; Xiong, Hui; Madsen, Louis A.; Zhao, Kejie; Shi, Feifei; Lin, Feng
作者单位：Virginia Polytechnic Institute & State University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Purdue University System; Purdue University; Purdue University in Indianapolis; Boise State University; United States Department of Energy (DOE); Brookhaven National Laboratory; Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University
摘要：Designing the solid-electrolyte interphase (SEI) is critical for stable, fast-charging, low-temperature Li-ion batteries. Fostering a fluorinated interphase, SEI enriched with LiF, has become a popular design strategy. Although LiF possesses low Li-ion conductivity, many studies have reported favorable battery performance with fluorinated SEIs. Such a contradiction suggests that optimizing SEI must extend beyond chemical composition design to consider spatial distributions of different chemica...
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作者：Tse, Megan W.; Zhu, Meilin; Peters, Benjamin; Hamami, Efrat; Chen, Julie; Davis, Kathleen P.; Nitz, Samuel; Weller, Juliane; Warrier, Thulasi; Hunt, Diana K.; Morales, Yoelkys; Kawate, Tomohiko; Gaulin, Jeffrey L.; Come, Jon H.; Hernandez-Bird, Juan; Huo, Wenwen; Neisewander, Isabelle; Yu, Xiao; Aceves-Salvador, Jose A.; Kiessling, Laura L.; Hung, Deborah T.; Mecsas, Joan; Aldridge, Bree B.; Isberg, Ralph R.; Blainey, Paul C.
作者单位：Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Tufts University; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Tufts University
摘要：Antibiotic resistance, especially in multidrug-resistant ESKAPE pathogens, remains a worldwide problem. Combination antimicrobial therapies may be an important strategy to overcome resistance and broaden the spectrum of existing antibiotics. However, this strategy is limited by the ability to efficiently screen large combinatorial chemical spaces. Here, we deployed a high-throughput combinatorial screening platform, DropArray, to evaluate the interactions of over 30,000 compounds with up to 22...
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作者：Iosilevskii, Yael; Hall, David H.; Katz, Menachem; Podbilewicz, Benjamin
作者单位：Technion Israel Institute of Technology; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University
摘要：Neurons display unique shapes and establish intricate networks, which may differ between sexes. In complex organisms, studying sex differences in structure and function of individual neurons is difficult. The nematode Caenorhabditis elegans hermaphrodites and males present an exceptional model for studying neuronal morphogenesis in a simple, sexually dimorphic system. We focus on the polymodal sensory bilateral neuron pair PVD, which forms a complex but stereotypic dendritic tree composed of m...
