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最新文章

• Toward a CRISPR-based mouse model of Vhl- deficient clear cell kidney cancer: Initial experience and lessons learned (vol 121, e2408549121, 2024) AI翻译
  作者：Stransky, Laura A.; Gao, Wenhua; Schmidt, Laura S.; Bi, Kevin; Ricketts, Christopher J.; Ramesh, Vijyendra; James, Amy; Difilippantonio, Simone; Ileva, Lilia; Kalen, Joseph D.; Karim, Baktiar; Jeon, Albert; Morgan, Tamara; Warner, Andrew C.; Turan, Sevilay; Unite, Joanne; Tran, Bao; Choudhari, Sulbha; Zhao, Yongmei; Linn, Douglas E.; Yun, Changhong; Dhandapani, Sripriya; Parab, Vaishali; Pinheiro, Elaine M.; Morris, Nicole; He, Lixia; Vigeant, Sean M.; Pignon, Jean-Christophe; Sticco-Ivins, Maura; Signoretti, Sabina; Van Allen, Eliezer M.; Linehan, W. Marston; Kaelin Jr, William G.
• Laser imaging of ancient tattoos: New tools illuminate established knowledge AI翻译
  作者：Wolf, Aaron Deter-; Robitaille, Benoit; Krutak, Lars
• Acute TREM2 inhibition depletes MAFB- high microglia and hinders remyelination AI翻译
  作者：Hou, Jinchao; Magliozzi, Roberta; Chen, Yun; Wu, Junjie; Wulf, John; Strout, Gregory; Fang, Xiangming; Colonna, Marco
  作者单位：Zhejiang University; Washington University (WUSTL); Imperial College London; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Zhejiang University
  摘要：We investigated the role of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) in myelin regeneration in the brain. TREM2 is a receptor that activates microglia, which are crucial for clearing myelin debris and promoting remyelination. Previous studies in a mouse model of demyelination induced by the copper-chelating agent Cuprizone (CPZ) have shown that stimulation of TREM2 with a monoclonal antibody reduces demyelination, while deleting the Trem2 gene in mice impairs remyelination. Her...
• The narrow search effect and how broadening search promotes belief updating AI翻译
  作者：Leung, Eugina; Urminsky, Oleg
  作者单位：Tulane University; University of Chicago
  摘要：Information search platforms, from Google to AI-assisted search engines, have transformed information access but may fail to promote a shared factual foundation. We demonstrate that the combination of users' prior beliefs influencing their search terms and the narrow scope of search algorithms can limit belief updating from search. We test this narrow search effect across 21 studies (14 preregistered) using various topics (e.g., health, financial, societal, political) and platforms (e.g., Goog...
• Bacteria on steroids AI翻译
  作者：Mrnjavac, Natalia; Martin, William F.
  作者单位：Heinrich Heine University Dusseldorf
• Cytoplasmic Mg2+supersedes carbon source preference to dictate Salmonella metabolism AI翻译
  作者：Pokorzynski, Nick D.; Jones, Katarina A.; Campagna, Shawn R.; Groisman, Eduardo A.
  作者单位：Yale University; University of Tennessee System; University of Tennessee Knoxville
  摘要：Glucose is the preferred carbon source of most studied microorganisms. However, we now report that glucose loses preferred status when the intracellular pathogen Salmonella enterica serovar Typhimurium experiences cytoplasmic magnesium (Mg2+) starvation. We establish that this infection-relevant stress drastically reduces synthesis of cyclic adenosine monophosphate (cAMP), the allosteric activator of the cAMP receptor protein (CRP), master regulator of carbon utilization. The resulting reducti...
• Striking the balance: Complexity, simplicity, and credibility in mathematical biology AI翻译
  作者：Rodero, Cristobal; Niederer, Steven A.
  作者单位：Imperial College London; Alan Turing Institute
• Climate change amplifies neurotoxic methylmercury threat to Asian fish consumers AI翻译
  作者：Wu, Mengjie; Wu, Xinda; Lopez, Alfonso; Blanchfield, Paul J.; Ren, Hongqiang; Zhong, Huan
  作者单位：Nanjing University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC)
  摘要：Climate change is intricately influencing the accumulation of neurotoxic methylmercury (MeHg) in human food webs, potentially leading to uneven exposure risks across regions. Here, we reveal that climate change will elevate MeHg risks in China, with implications for regional inequalities in Asia through a climate- mercury- food- health nexus. Using a compiled fish mercury dataset from 13,000 samples and machine learning, we find that freshwater wild fish-an essential component of the Asian die...
• Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia (vol 122, e2423169122, 2025) AI翻译
  作者：Wang, Jun-Yu; Gui, Tuan-Tuan; Jiao, Bo; Liu, Xuan; Ma, Xiao-Lin; Wang, Cheng; Qiao, Jing; Liu, Wei-Yang; Peng, Li-Jun; Ren, Jia-Yi; Zhu, Yong-Mei; Weng, Xiang-Qin; Wang, Chao; Zhang, Qian-Qian; Song, Gao-Xian; Dai, Yu-Ting; Wang, Zhen-Yi; Lv, Gang; Gao, Chen-Xu; Qiao, Niu; Zhang, Ming; Tan, Yun; Liu, Yuan-Fang; Wang, Sheng-Yue; Hou, Jian; Jing, Duo-Hui; Lyu, An-Kang; Mi, Jian-Qing; Chen, Zhu; Chen, Wen-Lian; Yin, Tong; Fang, Hai; Wang, Jin; Chen, Sai-Juan
• Belief in belief: Even atheists in secular countries show intuitive preferences favoring religious belief AI翻译
  作者：Gervais, Will M.; McKay, Ryan T.; Brown-Iannuzzi, Jazmin L.; Ross, Robert M.; Pennycook, Gordon; Jong, Jonathan; Lanman, Jonathan A.
  作者单位：Brunel University; University of London; Royal Holloway University London; University of Virginia; Macquarie University; Cornell University; Coventry University; Queens University Belfast
  摘要：We find evidence of belief in belief-intuitive preferences for religious belief over atheism, even among atheist participants-across eight comparatively secular countries. Religion is a cross-cultural human universal, yet explicit markers of religiosity have rapidly waned in large parts of the world in recent decades. We explored whether intuitive religious influence lingers, even among nonbelievers in largely secular societies. We adapted a classic experimental philosophy task to test for thi...