18期

最新文章

• Sexism in teams: Exposure to sexist comments increases emotional synchrony but eliminates its benefits for team performance AI翻译
  作者：Burns, Alon; Toker, Sharon; Berson, Yair; Gordon, Ilanit
  作者单位：Bar Ilan University; Tel Aviv University; McMaster University; Bar Ilan University; Yale University
  摘要：In a world where teams serve as the backbone of collaboration and innovation, women must feel safe when contributing to teamwork. Unfortunately, an increasing number of women report experiencing sexual harassment in workplaces and other collective settings. This research included an examination of how exposure to sexist insults affects collaborative efforts. We argue that in addition to its well- documented effects on individuals, sexism within teams undermines team performance. Hence, emotion...
• Compatibility of intracellular binding: Evolutionary design principles for metal sensors AI翻译
  作者：Lenner, Nicolas; Chariker, Logan; Leibler, Stanislas
  作者单位：Institute for Advanced Study - USA; Duke University; Rockefeller University
  摘要：In the common cellular space, hundreds of binding reactions occur reliably and enable this remarkable compatibility have not yet been adequately elucidated. In order to delineate these principles, we consider the intracellular sensing of transition metals in bacteria-an integral part of cellular metal homeostasis. Protein cytosolic sensors typically interact with metals through three types of lateral chain residues, containing oxygen, nitrogen, or sulfur. The very existence of complete sets of...
• Integrating single- cell data with biological variables AI翻译
  作者：Zhou, Yang; Sheng, Qiongyu; Jin, Shuilin
  作者单位：Harbin Institute of Technology; Harbin Institute of Technology
  摘要：Constructing single-cell atlases requires preserving differences attributable to biological variables, such as cell types, tissue origins, and disease states, while eliminating batch effects. However, existing methods are inadequate in explicitly modeling these biological variables. Here, we introduce SIGNAL, a general framework that leverages biological variables to disentangle biological and technical effects, thereby linking these metadata to data integration. SIGNAL employs a variant of pr...
• Mass- independent fractionation of oxygen isotopes during high- temperature condensation in cosmochemical plasmas AI翻译
  作者：Asset, Nathan; Chaussidon, Marc; Lombardi, Guillaume; Villeneuve, Johan; Tartese, Romain; Mostefaoui, Smail; Robert, Francois
  作者单位：Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); Universite de Lorraine; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); University of Manchester; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Museum National d'Histoire Naturelle (MNHN); Universite Paris Cite
  摘要：Contrary to all terrestrial rocks, planets and meteorites exhibit oxygen isotope variations decorrelated with the mass difference of their atomic nuclei. It has been proposed that, in the protosolar nebula (PSN), these variations could result from mass independent isotopic fractionation (MIF) either during specific chemical reactions similar to those responsible for the formation of ozone in the Earth's atmosphere or during ultraviolet (UV)- photolysis of carbon monoxide (CO) gas in the PSN. H...
• Comparative single- cell analysis of transcriptional bursting reveals the role of genome organization in de novo transcript origination AI翻译
  作者：Lee, Unjin; Li, Cong; Langer, Christopher B.; Svetec, Nicolas; Zhao, Li
  作者单位：Rockefeller University
  摘要：Spermatogenesis is a key developmental process underlying the origination of newly evolved genes. However, rapid cell type-specific transcriptomic divergence of the Drosophila germline has posed a significant technical barrier for comparative single- cell RNA- sequencing studies. By quantifying a surprisingly strong correlation between species- and cell type-specific divergence in three closely related Drosophila species, we apply a statistical procedure to identify a core set of 198 genes tha...
• NEUROD1 efficiently converts peripheral blood cells into neurons with partial reprogramming by pluripotency factors AI翻译
  作者：Saito, Yoichi; Ishikawa, Mitsuru; Ohkuma, Mahito; Moody, Jonathan; Mabuchi, Yo; Sanosaka, Tsukasa; Ando, Yoshinari; Yamashita, Takayuki; Hon, Chung Chau; Shin, Jay W.; Akamatsu, Wado; Okano, Hideyuki
  作者单位：Keio University; Keio University; Fujita Health University; Fujita Health University; RIKEN; Fujita Health University; Hiroshima University; Agency for Science Technology & Research (A*STAR); A*STAR - Genome Institute of Singapore (GIS); National University of Singapore; Juntendo University
  摘要：The direct reprogramming of cells has tremendous potential in in vitro neurological studies. Previous attempts to convert blood cells into induced neurons have presented several challenges, necessitating a less invasive, efficient, rapid, and convenient approach. The current study introduces an optimized method for converting somatic cells into neurons using a nonsurgical approach that employs peripheral blood cells as an alternative source to fibroblasts. We have demonstrated the efficacy of ...
• Persistent inequalities in global air quality monitoring should not delay pollution mitigation AI翻译
  作者：Smith, Keith; Lauriere, Camille Fournier de; Henninger, Ella
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Air pollution is a global health crisis that disproportionately affects lower- and middle-income countries. We examine global air quality monitoring data, highlighting persistent inequalities in high-exposure regions, and assess the potential of emerging technologies to improve data utility for mitigation. Improving air quality, however, does not need to wait for more data, nor will monitoring alone drive action. Immediate mitigation measures with broad cobenefits are needed now to reduce poll...
• Total whole- arm chromosome losses predict malignancy in human cancer AI翻译
  作者：Zheng, Ye; Ahmad, Kami; Henikoff, Steven
  作者单位：Fred Hutchinson Cancer Center; Howard Hughes Medical Institute; University of Texas System; UTMD Anderson Cancer Center
  摘要：Aneuploidy is observed as gains or losses of whole chromosomes or chromosome arms and is a common hallmark of cancer. Whereas models for the generation of aneuploidy in cancer invoke mitotic chromosome segregation errors, whole-arm losses might occur simply as a result of centromere breakage. We recently showed that elevated RNA Polymerase II level over the S-phase-dependent histone genes predicts rapid recurrence of human meningioma and is correlated with total whole-arm losses relative to ga...
• Inhaled DNAI1 mRNA therapy for treatment of primary ciliary AI翻译
  作者：Hennig, Mirko; Bhattacharjee, Rumpa B.; Agarwal, Ishita; Alfaifi, Ali; Casillas, Jade E.; Chavez, Sofia; Ishimaru, Daniella; Liston, David; Mohapatra, Sakya; Molla, Touhidul; Pathare, Suyog; Sidhu, Maninder S.; Wang, Peng; Wang, Zechen; Lombana, T. Noelle; Kharitonov, Vladimir G.; Couch, Jessica A.; Lockhart, David J.; Wustman, Brandon A.
  摘要：Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder caused by mutations in one of at least 50 different genes that encode proteins involved in the biogenesis, structure, or function of motile cilia. Genetically inherited defects in motile cilia cause PCD, a debilitating respiratory disease for which there is no approved therapy. The dynein axonemal intermediate chain 1 (DNAI1) protein is a key structural element of the ciliary outer dynein arm (ODA) critical for normal ciliary ...
• Decreased likelihood of schooling as a consequence of tropical cyclones: Evidence from 13 low-and middle-income countries AI翻译
  作者：Jing, Renzhi; Heft-Neal, Sam; Wang, Zetianyu; Chen, Jie; Qiu, Minghao; Opper, Isaac M.; Wagner, Zachary; Bendavid, Eran
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; RAND Corporation; Princeton University; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; University of Southern California
  摘要：Increasing educational attainment is one of the most important and effective strategies for health and economic improvements. The extent to which extreme climate events disrupt education, resulting in reduced educational attainment, remains understudied. Children in low- and middle-income countries (LMICs) may be uniquely vulnerable to losing schooling after disasters due to the poor physical condition of schools and the lack of resources to mitigate unexpected household shocks. Our analysis a...