-
作者：Burcroff, Amanda; Lee, Kyungyong; Mou, Lang
作者单位：Harvard University; University of Alabama System; University of Alabama Tuscaloosa; Korea Institute for Advanced Study (KIAS); University of Cologne
摘要：In 2013, Lee, Li, and Zelevinsky introduced combinatorial objects called compatible pairs to construct the greedy bases for rank-2 cluster algebras, consisting of indecomposable positive elements including the cluster monomials. Subsequently, Rupel extended this construction to the setting of generalized rank-2 cluster algebras by defining compatible gradings. We find a class of combinatorial objects which we call tight gradings. Using this, we give a directly computable, manifestly positive, ...
-
作者：Che, Yonglu; Lee, Jinwoo; Abou-Taleb, Farah; Rieger, Kerri E.; Satpathy, Ansuman T.; Chang, Anne Lynn S.; Chang, Howard Y.
作者单位：Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University
摘要：Immune checkpoint inhibitors such as anti-Programmed Death-1 antibodies (aPD-1) can be effective in treating advanced cancers. However, many patients do not respond, and the mechanisms underlying these differences remain incompletely understood. In this study, we profile a cohort of patients with locally advanced or metastatic basal cell carcinoma undergoing aPD-1 therapy using single-cell RNA sequencing, high-definition spatial transcriptomics in tumors and draining lymph nodes, and spatial i...
-
作者：Drake, Abby Grace; Revell, Liam J.; Klingenberg, Christian Peter; Lattimer, Jimmy C.; Nelson, Nathan C.; Schmidt, Martin J.; Zwingenberger, Allison L.; Moyer, Joshua K.; Losos, Jonathan B.
作者单位：Cornell University; University of Massachusetts System; University of Massachusetts Boston; University of Manchester; University of Missouri System; University of Missouri Columbia; North Carolina State University; Justus Liebig University Giessen; University of California System; University of California Davis; Yale University; Washington University (WUSTL)
摘要：Many domesticated species exhibit remarkable phenotypic diversity. In nature, selection produces not only divergence but also convergence when organisms experience similar selective pressures. Whether artificial selection during domestication also produces convergence has received little attention. Three-dimensional shape analysis of domestic cat and dog skulls demonstrated convergence at multiple levels. Most broadly, cats and dogs have both diversified greatly: equaling or exceeding the morp...
-
作者：Smith, Gregory P.; Zhu, Chenhui; Zernenkov, Mikail; Frechet, Guillaume; Clark, Noel A.
作者单位：University of Colorado System; University of Colorado Boulder; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Brookhaven National Laboratory
摘要：At high concentration, long Watson/Crick (WC) double-helixed DNA forms columnar crystal or liquid crystal phases of linear, parallel duplex chains packed on periodic lattices. This can also be a structural motif of short NA oligomers such as the 5'- GTAC-3' studied here, which makes four-base WC duplexes having hydrophobic blunt ends. End-to-end aggregation then assembles these duplexes into columns and columnar phases are stabilized, in spite of breaks in the double helix every four bases. Bu...
-
作者：Tian, Debin; Li, Wen; Heffron, C. Lynn; Mahsoub, Hassan M.; Wang, Bo; LeRoith, Tanya; Meng, Xiang-Jin
作者单位：Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University
摘要：Hepatitis E virus (HEV) genotype 1 (HEV-1) infection in pregnant women is associated with adverse outcomes of pregnancy including fulminant hepatic failure, fetal loss, premature birth, and neonatal mortality, although the underlying mechanisms remain largely unclear. In this study, we first demonstrated that HEV-1 robustly infects pregnant gerbils and causes pregnancy-associated adverse outcomes, which were recorded in 4/6 HEV-1-infected but only 1/5 in PBS-inoculated pregnant gerbils. Howeve...
-
作者：Wu, Jian; Tan, Jingqiang; Xu, Jinqi; Li, Lei; Beroza, Gregory C.; Mumford, Kevin G.; van de Ven, Cole; Chen, Baixi; Elsworth, Derek
作者单位：Central South University; University of Sydney; Central South University; Stanford University; Queens University - Canada; Carleton University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：China's shale gas production has grown annually by 21% since 2017 with long-term national energy strategy calling for continued expansion. This large-scale shale gas development is challenged by constraints on water supply. It requires over 6,000 new wells to be drilled within the Yangtze River Basin in South China-one of China's most populated regions with sensitive ecological and geological conditions, posing significant environmental threats to the hydrosphere, atmosphere, and biosphere. Hy...
-
作者：Das, Amiya Prakash; Zhao, Jidong; Sweijen, Thomas
作者单位：Hong Kong University of Science & Technology; Utrecht University
摘要：This paper presents pore unit assembly-discrete element model (PUA-DEM), a pore-scale hydromechanical framework that resolves interactions between mobile granular particles and multiphase fluids in unsaturated granular media. The framework uniquely integrates DEM with pore-scale hydrodynamic models to capture unsaturated flow dynamics, while leveraging a two-way coupling mechanism to ensure bidirectional fluid-grain feedback through stabilized domain partitioning. Further innovations include a...
-
作者：Dura, Tina; Chilton, William; Small, David; Garner, Andra J.; Hawkes, Andrea; Melgar, Diego; Engelhart, Simon E.; Staisch, Lydia M.; Witter, Robert C.; Nelson, Alan R.; Kelsey, Harvey M.; Allan, Jonathan C.; Bruce, David; Depaolis, Jessica; Priddy, Michael; Briggs, Richard W.; Weiss, Robert; La Selle, Seanpaul; Willis, Michael; Horton, Benjamin P.
作者单位：Virginia Polytechnic Institute & State University; University of Oregon; Rowan University; University of North Carolina; University of North Carolina Wilmington; Durham University; United States Department of the Interior; United States Geological Survey; United States Department of the Interior; United States Geological Survey; United States Department of the Interior; United States Geological Survey; California State University System; California State Polytechnic University Pomona; United States Department of the Interior; United States Geological Survey; City University of Hong Kong; Nanyang Technological University; Nanyang Technological University
摘要：Climate-driven sea-level rise is increasing the frequency of coastal flooding worldwide, exacerbated locally by factors like land subsidence from groundwater and resource extraction. However, a process rarely considered in future sea-level rise scenarios is sudden (over minutes) land subsidence associated with great (>M8) earthquakes, which can exceed 1 m. Along the Washington, Oregon, and northern California coasts, the next great Cascadia subduction zone earthquake could cause up to 2 m of s...
-
作者：Martin, Mariano; Bolognesi, Benedetta
作者单位：Barcelona Institute of Science & Technology; Institut de Bioenginyeria de Catalunya; University of Barcelona
摘要：Stop-loss mutations cause over twenty different diseases. The effects of stop-loss mutations can have multiple consequences that are, however, hard to predict. Stop-loss in ITM2B/BRI2 results in C-terminal extension of the encoded protein and, upon furin cleavage, in the production of two 34 amino acid long peptides, ADan and ABri, that accumulate as amyloids in the brains of patients affected by familial Danish and British Dementia. To systematically explore the consequences of Bri2 C-termina...
-
作者：Borgstahl, Gloria E. O.
作者单位：University of Nebraska System; University of Nebraska Medical Center
