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作者：Gori, Kevin; Baez-Ortega, Adrian; Strakova, Andrea; Stammnitz, Maximilian R.; Wang, Jinhong; Chan, Jonathan; Hughes, Katherine; Belkhir, Sophia; Hammel, Maurine; Moralli, Daniela; Bancroft, James; Drydale, Edward; Allum, Karen M.; Brignone, Maria Veronica; Corrigan, Anne M.; de Castro, Karina F.; Donelan, Edward M.; Faramade, Ibikunle A.; Hayes, Alison; Ignatenko, Nataliia; Karmacharya, Rockson; Koenig, Debbie; Lanza-Perea, Marta; Quintana, Adriana M. Lopez; Meyer, Michael; Neunzig, Winifred; Pedraza-Ordonez, Francisco; Phuentshok, Yoenten; Phuntsho, Karma; Ramirez-Ante, Juan C.; Reece, John F.; Schmeling, Sheila K.; Singh, Sanjay; Martinez, Lester J. Tapia; Taulescu, Marian; Thapa, Samir; Thapa, Sunil; van der Wel, Mirjam G.; Wehrle-Martineza, Alvaro S.; Stratton, Michael R.; Murchison, Elizabeth P.
作者单位：University of Cambridge; Wellcome Trust Sanger Institute; University of Cambridge; University of Oxford; University of Oxford; University of Buenos Aires; Universidade Estadual Paulista; Universidad de Caldas; University of Agricultural Sciences & Veterinary Medicine Cluj Napoca; Universidad Nacional de Asuncion
摘要：Horizontal transfer of nuclear DNA between cells of host and cancer is a potential source of adaptive variation in cancer cells. An understanding of the frequency and significance of this process in naturally occurring tumors is, however, lacking. We screened for this phenomenon in the transmissible cancers of dogs and Tasmanian devils and found an instance in the canine transmissible venereal tumor (CTVT). This involved introduction of a 15-megabase dicentric genetic element, composed of 11 f...
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作者：Yoon, Hongsup; Gerdes, Lisa Ann; Beigel, Florian; Sun, Yihui; Koevilein, Janine; Wang, Jiancheng; Kuhlmann, Tanja; Flierl-Hecht, Andrea; Haller, Dirk; Hohlfeld, Reinhard; Baranzini, Sergio E.; Wekerle, Hartmut; Peters, Anneli
作者单位：University of Munich; University of Munich; University of Munich; University of Munich; University of California System; University of California San Francisco; University of Munster; Technical University of Munich; Handong Global University
摘要：We developed a two-tiered strategy aiming to identify gut bacteria functionally linked to the development of multiple sclerosis (MS). First, we compared gut microbial profiles in a cohort of 81 monozygotic twins discordant for MS. This approach allowed to minimize confounding effects by genetic and early environmental factors and identified over 50 differently abundant taxa with the majority of increased taxa within the Firmicutes. These included taxa previously described to be associated with...
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作者：Izdebski, Adam; Czerwinski, Sambor; Jankowiak, Marek; Danielewski, Marcin; Fiolna, Sabina; Gromig, Raphael; Guzowski, Piotr; Haghipour, Negar; Hajdas, Irka; Kolaczek, Piotr; Lamentowicz, Mariusz; Marcisz, Katarzyna; Niebieszczanski, Jakub; Sankiewicz, Pawel; Wagner, Bernd
作者单位：Max Planck Society; University of Warsaw; University of Warsaw; Fahrenheit Universities; University of Gdansk; Adam Mickiewicz University; Free University of Berlin; Simon Fraser University; University of Cologne; University of Bialystok; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Adam Mickiewicz University
摘要：Rapid social-ecological intensification is a recurrent feature of human history. It occurred in different forms and contexts; its outcomes may have been sustainable or transient. Until recently, such intensifications usually accompanied state formation: Consolidation of political power was often coupled with exponential increase in human exploitation of the environment of a given area. Here, we study one such case, uniquely well-documented through our rich paleoecological, archaeological, numi...
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作者：Amado, Pedro; Dillinger, Cornel; Bahou, Chaimae; Gheinani, Ali Hashemi; Obrist, Dominik; Burkhard, Fiona; Ahmed, Daniel; Clavica, Francesco
作者单位：University of Bern; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Bern; University Hospital of Bern; University of Bern; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Biofilm formation and encrustation are major issues in indwelling medical devices, such as urinary stents and catheters, as they lead to blockages and infections. Currently, to limit these effects, frequent replacements of these devices are necessary, resulting in a significant reduction in patients' quality of life and an increase in healthcare costs. To address these challenges, by leveraging recent advancements in robotics and microfluidic technologies, we envision a self-cleaning system fo...
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作者：Ma, Wei; Ma, Lai - Peng; Kong, Xiao; Yan, Han; Liu, Zhibo; Han, Tiannan; Zhu, Chao; Cheng, Hui - Ming; Liu, Zheng; Ding, Feng; Ren, Wencai
作者单位：Chinese Academy of Sciences; Institute of Metal Research, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Nanyang Technological University; Chinese Academy of Sciences; Shanghai Institute of Microsystem & Information Technology, CAS; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; National University of Singapore; Institute for Functional Intelligent Materials (I-FIM); Suzhou Laboratory
摘要：State- of- the- art synthesis strategies of two- dimensional (2D) materials have been designed following the nucleation- dominant pattern for structure control. However, this classical methodology fails to achieve the precise layer- and stacking- resolved growth of wafer- scale few- layer 2D materials due to its intrinsically low energy resolution. Here, we present an intelligent self- correcting method for the high- resolution growth of uniform few- layer graphene. We demonstrate the layer- r...
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作者：Shriver, Robert K.; Pletcher, Elise; Biondi, Franco; Urza, Alexandra K.; Weisberg, Peter J.
作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; United States Department of Agriculture (USDA); United States Forest Service
摘要：Recent increases in woody plant density in dryland ecosystems-or woody encroachment-around the world are often attributed to land-use changes such as increased livestock grazing and wildfire suppression or to global environmental trends (e.g., increasing atmospheric carbon dioxide). While such changes have undoubtedly impacted ecosystem structure and function, the evidence linking them to woody encroachment is mixed, and the underlying processes are not fully understood. To clarify the role of...
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作者：Liu, Ying; Kendall, John Michael; Zhang, Haijiang; Blundy, Jonathan D.; Pritchard, Matthew E.; Hudson, Thomas; MacQueen, Patricia
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; University of Oxford; Cornell University; Swiss Federal Institutes of Technology Domain; ETH Zurich; United States Department of the Interior; United States Geological Survey
摘要：For a volcanic system, evaluating potential eruption probability requires understanding the extent of melt and gas accumulation in the upper crustal reservoir, which is challenging to resolve. Here, we jointly use geophysical imaging and petrophysical analysis to unravel the current state and pathway of gas or supercritical fluids in the upper crust beneath Uturuncu volcano in Bolivia. Although it last erupted 250 +/- 5 ka ago, Uturuncu remains active with observable deformation and seismicity...
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作者：Chang, Ni-Chen; Wells, Jonathan N.; Wang, Andrew Y.; Schofield, Phillip; Huang, Yi-Chia; Truong, Vinh H.; Simoes-Costa, Marcos; Feschotte, Cedric
作者单位：Cornell University; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
摘要：Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE- derived sequences repurposed for organismal function. The process by which TEs become coopted remains obscure because most cases involve ancient, transpositionally inactive elements. Reports of active TEs serving beneficial functions are scarce and often contentious due to difficulties in manipulating repetitive sequences. Here, we show that recently active TEs in zebrafish encode products critical fo...
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作者：Zhang, Liyang; Yang, Jingxuan; Zhou, Zhijun; Ren, Yu; Chen, Bo; Tang, Anliu; Zhang, Kailiang; Li, Chuntao; Zhou, Hongshu; Fung, Kar - Ming; Xu, Chao; Kang, Chunsheng; Battiste, James D.; Bronze, Michael S.; Houchen, Courtney W.; Liu, Zhixiong; Dunn, Ian F.; Cavenee, Webster K.; Li, Min
作者单位：University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; Central South University; Central South University; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; Tianjin Medical University; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of California System; University of California San Diego
摘要：Glioblastoma (GBM) is the most aggressive form of brain cancer, with limited therapeutic options. While microglia contribute to GBM progression, the mechanisms by which they foster a protumorigenic immune environment remain poorly understood. We identify the zinc transporter Zrt-And Irt-Like Protein 4 (ZIP4) as a pivotal regulator of the GBM immune landscape. In orthotopic mouse models, ZIP4 drives tumor growth and behavioral changes. Mechanistically, ZIP4 modulates microglial plasticity throu...
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作者：Beans, Carolyn
