作者：Brill, Julia; Clarke, Blaise; Hong, Ingie; Huganir, Richard L.
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine
摘要：SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intellectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through its GAP enzymatic activity, SYNGAP1 plays an important structural role through its interaction with postsynaptic density proteins. Here, we reveal that intrinsic excitability deficits and seizure phenotypes in heterozygous Syngap1 knockout (KO) mic...
作者：McTavish, Emily Jane; Gerbracht, Jeff A.; Holder, Mark T.; Iliff, MarshallJ.; Lepage, Denis; Rasmussen, Pamela C.; Redelings, Benjamin D.; Reyes, Luna L. Sanchez; Miller, Eliot T.
作者单位：Cornell University; University of Kansas; University of Kansas
摘要：We present a complete, time-scaled, evolutionary tree of the world's bird species. This tree unites phylogenetic estimates for 9,239 species from 262 studies published between 1990 and 2024, using the Open Tree synthesis algorithm. The remaining species are placed in the tree based on curated taxonomic information. The tips of this complete tree are aligned to the species in the Clements Taxonomy used by eBird and other resources, and cross-mapped to other taxonomic systems including the Open ...
