18期

最新文章

• Behavioral resilience via dynamic circuit firing homeostasis AI翻译
  作者：Hoagland, Adam; Schultz, Ryan; Cai, Zerong; Newman, Zachary L.; Isacoff, Ehud Y.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Homeostatic regulation ensures stable neural circuit output under changing conditions. We find that in Drosophila larvae, either presynaptic weakening due to perturbation of transmitter release or postsynaptic weakening due to perturbation of glutamate receptors at synapses between motor neuron (MN) and muscle has little impact on locomotion, suggesting a nonsynaptic compensatory mechanism. In vivo imaging shows that five different forms of synaptic weakening increase the duration of activity ...
• Twinfilin is a nonprocessive depolymerase which synergizes with formin to dramatically accelerate actin filament uncapping by 300-fold AI翻译
  作者：Reddy, Vishal; Arya, Ankita; Shekhar, Shashank
  作者单位：Emory University; Emory University
  摘要：For over four decades, our understanding of cellular actin dynamics has been guided by the concept of treadmilling. However, this paradigm has been challenged by the evidence that twinfilin can uncap and promote depolymerization of filament barbed ends, though its precise mechanism remains debated. Using single-molecule microscopy and microfluidics-assisted TIRF imaging, we demonstrate that twinfilin transiently associates with barbed ends for similar to 0.2 to 0.5 s, acting as a nonprocessive...
• Dysregulation of MYBL2 impairs extravillous trophoblast lineage development and function, contributing to recurrent spontaneous abortion AI翻译
  作者：Wu, Zhi-Hong; Yi, Cen; Chen, En-Xiang; Xu, Jia-Qi; Li, Cong; Yao, Lu; Li, Fang-Fang; Fu, Li-Juan; Ge, Lu-Xing; Wang, Ying-Xiong; Xie, You-Long; Ding, Yu-Bin; Tang, Jing
  作者单位：Chongqing Medical University; Chongqing Medical University; Chongqing Medical University; Changsha Medical University
  摘要：Recurrent spontaneous abortion (RSA) is a pregnancy- related condition characterized by a complex etiology. While placental trophoblast dysfunction is strongly associated with the development and progression of RSA, the underlying molecular mechanisms remain poorly understood. In this study, we observed a significant decrease in the expression and the placentas of abortion- prone (AP) mice. Utilizing human trophoblast stem cells (hTSCs), we identified MYBL2 as a critical regulator of hTSCs ste...
• Accurate identification and mechanistic evaluation of pathogenic missense variants with Rhapsody- 2 AI翻译
  作者：Banerjee, Anupam; Bogetti, Anthony T.; Bahar, Ivet
  作者单位：State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Stony Brook University Hospital
  摘要：Understanding the effects of missense mutations or single amino acid variants (SAVs) on protein function is crucial for elucidating the molecular basis of diseases/disorders and designing rational therapies. We introduce here Rhapsody-2, a machine learning tool for discriminating pathogenic and neutral SAVs, significantly expanding on a precursor limited by the availability of structural data. With the advent of AlphaFold2 as a powerful tool for structure prediction, Rhapsody-2 is trained on a...
• Jellyfish shape as a mechanical balance (vol 122, e2412082122, 2025) AI翻译
  作者：Gong, Mengsha; Ashok, Minakshi; Helou, Ariane; Goentoro, Lea
• Quantification and potential functional relevance of binding cooperativity of adjacent transcription factors on DNA AI翻译
  作者：Wang, Xinyao; Xie, Chen; Shen, Ke; Li, Dubai; Xie, Xiaoliang Sunney
  作者单位：Peking University; Peking University; Changping Laboratory; Peking University
  摘要：In eukaryotes, the expression of specific genes is regulated by a combination of transcription factors (TFs) bound on regulatory regions of the genomic DNA (promoters and enhancers). Recent advances in genomic sequencing technology have enabled the measurements of TFs' footprints and binding affinities on DNA at the single-molecule level, facilitating the probing of binding cooperativity among adjacent TFs. This necessitates quantitative descriptions of TFs' binding cooperativity and understan...
• Toward quantitative X-ray elastography of coronary arteries using flexural pulse waves AI翻译
  作者：Gregoire, Sibylle; Laloy-Borgna, Gabrielle; Rouviere, Olivier; Giammarinaro, Bruno; Catheline, Stefan; Weitz, David
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Delft University of Technology; Universite Claude Bernard Lyon 1; CHU Lyon
  摘要：Dynamic elastography uses an imaging system to visualize the propagation of elastic waves, the speed of which is directly related to the elasticity felt by palpation. Very few studies have focused on X-ray elastography because of the technical challenges it poses: a planar image of an integration volume at a very slow sampling rate. We demonstrate that tracking a slow elastic wave guided along a one-dimensional structure could provide a possible solution. The recently discovered flexural pulse...
• Bacterial extracellular vesicles target different bacterial species, impairing cell division and diminishing their pathogenicity AI翻译
  作者：Kawagishi, Yu; Murase, Kazunori; Grebenshchikova, Anna; Iibushi, Junpei; Ma, Chang; Kimeu, Teresia M.; Minowa-Nozawa, Atsuko; Nozawa, Takashi; Nakagawa, Ichiro
  作者单位：Kyoto University; Japan Institute for Health Security (JIHS); National Institute of Infectious Diseases (NIID); Kyoto University
  摘要：Extracellular vesicles (EVs) produced by bacteria contain many bacterial-derived molecules, which play an important role in host interactions and as mediators of bacterial communication. However, the role of EVs in interspecies interactions and their physiological and ecological significance are not well understood. In this study, we found that Escherichia coli EVs inhibit the growth of group A Streptococcus (GAS; Streptococcus pyogenes) by inducing defective cell division via the following pr...
• Exposure and health risks of livestock air resistomes AI翻译
  作者：Sun, Wei; Wang, Jun; Wang, Guangdong; Jiang, Lan; Feng, Wenlu; Dang, Shuangsuo; Li, Mei; Jiao, Shuo; Wei, Gehong; Gu, Jie; Tiedje, James M.; Qian, Xun
  作者单位：Northwest A&F University - China; Northwest A&F University - China; Northwest A&F University - China; Xi'an Jiaotong University; Northwest A&F University - China; Michigan State University
  摘要：Most of the global antibiotic consumption is by the livestock industry, making livestock sure to workers, but the health risks of air resistomes remain unclear. We evaluated the human exposure and health risks of air resistomes in pig and chicken farms and compared air resistomes in Chinese farms to those in European farms given their long- term restrictions on use of antibiotics in livestock. We found that livestock air was highly enriched in ARGs, with each cell harboring seven times more AR...
• Four-million-year Marinoan snowball shows multiple routes to deglaciation AI翻译
  作者：Tasistro-Hart, Adrian R.; Macdonald, Francis A.; Crowley, James L.; Schmitz, Mark D.
  作者单位：University of California System; University of California Berkeley; Boise State University
  摘要：Twice during the Neoproterozoic Era, Earth experienced runaway ice-albedo catastrophes that resulted in multimillion year, low-latitude glaciations: the Sturtian and Marinoan snowball Earths. In the snowball climate state, CO2 consumption through silicate weathering collapses, and atmospheric CO2 accumulates via volcanic outgassing until a sufficiently strong greenhouse causes deglaciation. The duration and extent of ice cover are critical for planetary habitability, both on exoplanets and on ...