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• Immobile lipopolysaccharides and outer membrane proteins differentially segregate in growing Escherichia coli AI翻译
  作者：Kumar, Sandip; Inns, Patrick G.; Ward, Scott; Lagage, Valentine; Wang, Jingyu; Kaminska, Renata; Booth, Martin J.; Uphoff, Stephan; Cohen, Edward A. K.; Mamou, Gideon; Kleanthous, Colin
  作者单位：University of Oxford; Imperial College London; University of Oxford; Hebrew University of Jerusalem
  摘要：The outer membrane (OM) of gram-negative bacteria is a robust, impermeable barrier that excludes many classes of antibiotics. Contrary to the classical model of an asymmetric lipid bilayer, recent evidence suggests the OM is predominantly an asymmetric integral beta-barrel outer membrane proteins (OMPs) are shared with other OMPs to form a supramolecular network in which the levels of OMPs approach those of LPS. Some of the most abundant OMPs in the Escherichia coli OM are trimeric porins. How...
• Evolution of the JULGI-SMXL4/5 module for phloem development in angiosperms AI翻译
  作者：Park, Chanyoung; Cho, Hyun Seob; Lim, Yookyung; Cho, Chung Hyun; Nam, Hoyoung; Choi, Sangkyu; Lim, Hojun; Kim, Young - Dong; Yoon, Hwan Su; Cho, Hyunwoo; Hwang, Ildoo
  作者单位：Pohang University of Science & Technology (POSTECH); Chungbuk National University; Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI); Hallym University; Sungkyunkwan University (SKKU)
  摘要：Bifacial cambium, which produces xylem and phloem, and monopodial architecture, characterized by apical dominance and lateral branching from axillary buds, are key developmental features of seed plants, consisting of angiosperms and gymnosperms. These allow seed plants to adapt to diverse environments by optimizing resource allocation and structural integrity. In seed plants, SUPPRESSOR OFMAX2-LIKE (SMXL) family members function in phloem development and strigolactone-induced inhibition of axi...
• HCV NS3/4A protease relocalizes CCTα to viral replication sites, enhancing phosphatidylcholine synthesis and viral replication AI翻译
  作者：Sarwar, Shamila; Randall, Glenn
  作者单位：University of Chicago
  摘要：Positive-sense single-stranded RNA [(+)RNA] viruses constitute more than one-third of all virus genera, including numerous pathogens of clinical significance. All (+)RNA viruses reorganize cellular membranes from organelles to establish replication compartments (RCs). These RCs are thought to form a platform for membrane-associated replicases, in addition to protecting the viral RNAs from cytosolic innate immune signaling and RNA-degradation machinery.Previous work demonstrated that three fami...
• Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction (vol 116, pg 18435, 2019) AI翻译
  作者：Qian, Wei; Kumar, Namrata; Roginskaya, Vera; Fouquerel, Elise; Opresko, Patricia L.; Shiva, Sruti; Watkins, Simon C.; Kolodieznyi, Dmytro; Bruchez, Marcel P.; Van Houten, Bennett
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Carnegie Mellon University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Carnegie Mellon University; Carnegie Mellon University
• Independent and combined effects of long- term air pollution exposure and genetic predisposition on COVID-19 severity: A population- based cohort study AI翻译
  作者：Ma, Yudiyang; Wang, Jianing; Cui, Feipeng; Tang, Linxi; Khalid, Sara; Tian, Yaohua; Xie, Junqin
  作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Nuffield Orthopaedic Centre; University of Oxford; University of Oxford; University of Oxford
  摘要：The relationships between air pollution, genetic susceptibility, and COVID-19-related outcomes, as well as the potential interplays between air pollution and genetic susceptibility, remain largely unexplored. The Cox proportional hazards model was used to assess associations between long-term exposure to air pollutants and the risk of COVID-19 outcomes (infection, hospitalization, and death) in a COVID-19-naive cohort (n = 458,396). Additionally, associations between air pollutants and the ris...
• Stereospecific control of microbial growth by a combinatoric suite of chiral siderophores AI翻译
  作者：Stow, Parker R.; Forsch, Kiefer O.; Thomsen, Emil; Naka, Hiroaki; Haygood, Margo G.; Barbeau, Katherine A.; Butler, Alison
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California San Diego; Scripps Institution of Oceanography; Utah System of Higher Education; University of Utah
  摘要：Bacteria compete for iron by producing small-molecule chelators known as siderophores. The triscatechol siderophores trivanchrobactin and ruckerbactin, produced by Vibrio campbellii DS40M4 and Yersinia ruckeri YRB, respectively, are naturally occurring diastereomers that form chiral ferric complexes in opposing enantiomeric configurations. Chiral recognition is a hallmark of specificity in biological systems, yet the biological consequences of chiral coordination compounds are relatively unexp...
• S- nitrosylation- triggered secretion of mycobacterial PknG leads to phosphorylation of SODD to prevent apoptosis of infected macrophages AI翻译
  作者：Saha, Saradindu; Roy, Sadhana; Hazra, Arnab; Das, Debayan; Kumar, Vimal; Singh, Amit Kumar; Singh, Ajay Vir; Mondal, Rajesh; Dasgupta, Somdeb Bose
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kharagpur; Indian Council of Medical Research (ICMR); ICMR - National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra; Indian Council of Medical Research (ICMR); Indian Council of Medical Research (ICMR); ICMR - National Institute for Research in Tuberculosis (NIRT); Indian Council of Medical Research (ICMR); ICMR - National Institute for Research in Environmental Health (NIREH)
  摘要：The tuberculosis-causing agent Mycobacterium tuberculosis (M.tb) establishes its niche inside macrophages by secretion of several virulence factors and engaging many host factors. Mycobacterial infection of macrophages results in a proinflammatory trigger-mediated secretion of TNFc. Protein kinase G (PknG), a Serine/Threonine kinase, is essential for mycobacterial survival within the macrophage. Pathogenic mycobacteria, upon infection, can trigger the secretion of proinflammatory cytokine TNFc...
• The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells AI翻译
  作者：Jin, Jiacheng; Zhang, Ruohan; Li, Jianying; Gao, Fengxia; Liao, Zhiwei; Yu, Yanbao; Wang, Yi; Bucci, Donna; Xiao, Min; Ma, Ruilin; Ma, Qin; Gao, Shuaixin; Lio, Jerry; Novais, Fernanda; Huang, Stanley Ching- Cheng; Zhu, Jiangjiang; Ghoneim, Hazem; Wen, Haitao; Li, Zihai; Sun, Nuo; Xin, Gang
  作者单位：University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University of Delaware; New York University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
  摘要：Optimal activation of CD8+ T cells is crucial for immunity-mediated destruction of cancer, requiring a substantial amount of proteins involved in metabolism, proliferation, and effector function. Despite extensive studies emphasizing the role of transcriptional regulation in this process, paired transcriptomic and proteomic analyses reveal that the RNA profile is poorly correlated with protein levels. This discrepancy underscores the importance of post-translational modifications (PTMs) in con...
• Structural basis of SARS-CoV-2 polymerase inhibition by nonnucleoside inhibitor HeE1-2Tyr AI翻译
  作者：Kabinger, Florian; Doze, Valerie; Schmitzova, Jana; Lidschreiber, Michael; Dienemann, Christian; Cramer, Patrick
  摘要：Targeting the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 with small molecules is a promising therapeutic strategy against COVID-19, but potent and safe inhibitors are lacking. HeE1-2Tyr, a nonnucleoside inhibitor of Dengue virus RdRp, was also shown to inhibit SARS-CoV-2 RdRp in vitro and to have antiviral activity in cells, but the underlying mechanism remains unclear. Here, we elucidate the molecular mechanism of HeE1-2Tyr-mediated SARS-CoV-2 RdRp inhibition. Biochemical assays confir...
• Characterizing sliding and rolling contacts between single particles AI翻译
  作者：Scherrer, Simon; Ramakrishna, Shivaprakash N.; Niggel, Vincent; Hsu, Chiao-Peng; Style, Robert W.; Spencer, Nicholas D.; Isa, Lucio
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Technical University of Munich
  摘要：Contacts between particles in dense, sheared suspensions are believed to underpin much of their rheology. Roughness and adhesion are known to constrain the relative motion of particles, and thus globally affect the shear response, but an experimental description of how they microscopically influence the transmission of forces and relative displacements within contacts is lacking. Here, we show that an innovative colloidal-probe atomic force microscopy technique allows the simultaneous measurem...