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作者：Johnson, Evan C.
作者单位：University of Alberta
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作者：Manik, Mohammad K.; Pan, Mengqi; Xiao, Le; Gu, Weixi; Kim, Hyoyoung; Pospich, Sabrina; Hedger, Andrew; Vajjhala, Parimala R.; Lee, Morris Y. L.; Qian, Xiaoqi; Landsberg, Michael J.; Ve, Thomas; Nanson, Jeffrey D.; Raunser, Stefan; Stacey, Katryn J.; Wu, Hao; Kobe, Bostjan
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作者：Gong, Zhou; Zhang, Xu; Liu, Maili; Jin, Changwen; Hu, Yunfei
作者单位：Chinese Academy of Sciences; Innovation Academy for Precision Measurement Science & Technology, CAS; Peking University; Chinese Academy of Sciences; Peking University
摘要：Despite the growing number of G protein-coupled receptor (GPCR) structures being resolved, the dynamic process of how GPCRs transit from the inactive toward the active state remains unclear. In this study, comprehensive molecular dynamics simulations were performed to explore how ligand binding modulates the conformational dynamics of the M2 muscarinic acetylcholine receptor (M2R). We observed a sequential occurrence of structural changes in the inactive- to- active transition of M2R induced b...
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作者：Aguilar-Gomez, Sandra; Cardenas, Juan Camilo; Diaz, Ricardo Salas
作者单位：Universidad de los Andes (Colombia); University of Massachusetts System; University of Massachusetts Amherst; Dartmouth College
摘要：Recent research, focused mostly on the United States and Western Europe, shows that marginalized communities often face greater environmental degradation. However, the ethnoracial categories used in these studies may not fully capture environmental inequality in the Global South. Moving beyond conventional ethnoracial variables, this study presents findings exploring the link between skin tone and fine particulate matter (PM2.5) exposure in Colombia. By matching household geolocations from a l...
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作者：Qin, Gege; Shao, Xiying; Liu, Xiaolong; Xu, Jiachao; Wang, Xiaojia; Wang, Wenxi; Gao, Lu; Liang, Yuxin; Xie, Lina; Su, Dan; Yang, Hongwei; Zhou, Wei; Fan, Xiaohong
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作者：Ramkumar, Nitya; Richardson, Christian; O'Brien, Makinnon; Butt, Faraz Ahmed; Park, Jieun; Chao, Anna T.; Bagnat, Michel; Poss, Kenneth D.; Di Talia, Stefano
作者单位：Duke University; Duke University; Duke University; University of Wisconsin System; University of Wisconsin Madison; The Morgridge Institute for Research, Inc.; University of Wisconsin System; University of Wisconsin Madison; Duke University
摘要：Elongation of the vertebrate embryonic axis necessitates rapid expansion of the epidermis to accommodate the growth of underlying tissues. Here, we generated a toolkit to visualize and quantify signaling in entire cell populations of the periderm, the outermost layer of the epidermis, in live developing zebrafish. We find that oriented cell divisions facilitate growth of the early periderm during axial elongation rather than cell addition from the basal layer. Activity levels of Extracellular ...
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作者：Rosen, Paul C.; Horwitz, Samantha M.; Brooks, Daniel J.; Kim, Erica; Ambarian, Joseph A.; Waidmann, Lidia; Davis, Katherine M.; Yellen, Gary
作者单位：Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Emory University
摘要：Genetically encoded biosensors can measure biochemical properties such as small-molecule concentrations with single-cell resolution, even in vivo. Despite their utility, these sensors are black boxes: Very little is known about the structures of their low-and high-fluorescence states or what features are required to transition between them. We used LiLac, a lactate biosensor with a quantitative fluorescence-lifetime readout, as a model system to address these questions. X-ray crystal structure...
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作者：Gao, Jinjun; Liu, Ruilong; Huang, Kevin; Li, Ziyuan; Sheng, Xinlei; Chakraborty, Kasturi; Han, Chang; Zhang, Di; Becker, Lev; Zhao, Yingming
作者单位：University of Chicago; Cornell University; University of Wisconsin System; University of Wisconsin Madison; Peking University; Peking University; Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University
摘要：The recently identified histone modification lysine lactylation can be stimulated by L- lactate and glycolysis. Although the chemical group added upon lysine lactylation was originally proposed to be the L- enantiomer of lactate (KL- la), two isomeric modifications, their precursors being metabolites of glycolysis. The dynamic regulation and differences among these three modifications in response to hypoxia remain poorly understood. In this study, we demonstrate that intracellular KL- la, but ...
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作者：Wang, Po-Hsiang; Wu, Tien-Yu; Chen, Yi-Lung; Gicana, Ronnie G.; Lee, Tzong-Huei; Chen, Mei-Jou; Hsiao, Tsun-Hsien; Lu, Mei-Yeh Jade; Lai, Yi-Li; Wang, Tzi-Yuan; Li, Jeng-Yi; Chiang, Yin-Ru
作者单位：National Central University; Academia Sinica - Taiwan; National Taiwan University; National Taiwan University; National Taiwan University; National Taiwan University Hospital; National Taiwan University; National Tsing Hua University
摘要：Androgen and estrogen, key sex hormones, were long thought to be exclusively produced by vertebrates. The O2-dependent aromatase that converts androgen to estrogen (estrogenesis) has never been identified in any prokaryotes. Here, we report the finding of anaerobic estrogenesis in a Peptococcaceae bacterium (Phosphitispora sp. strain TUW77) isolated from the gut of the great blue-spotted mudskipper (Boleophthalmus pectinirostris). This strain exhibits testosterone fermentation pathways, transf...
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作者：Campbell, Polly; Heitzmann, Louise D.
作者单位：University of California System; University of California Riverside
