作者：Nartallo-Kaluarachchi, Ramon; Bonetti, Leonardo; Fernandez-Rubio, Gemma; Vuust, Peter; Deco, Gustavo; Kringelbach, Morten L.; Lambiotte, Renaud; Goriely, Alain
作者单位：University of Oxford; University of Oxford; Alan Turing Institute; Aarhus University; University of Oxford; University of Barcelona; Pompeu Fabra University; Pompeu Fabra University; ICREA
摘要：Information processing in the human brain can be modeled as a complex dynamical system operating out of equilibrium with multiple regions interacting nonlinearly. Yet, despite extensive study of the global level of nonequilibrium in the brain, quantifying the irreversibility of interactions among brain regions at multiple levels remains an unresolved challenge. Here, we present the Directed Multiplex Visibility Graph Irreversibility framework, a method for analyzing neural recordings using net...
作者：Goret, Marie; Thomas, Morgane; Edelweiss, Evelina; Messaddeq, Nadia; Laporte, Jocelyn
作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm)
摘要：Charcot-Marie-Tooth (CMT) disease, the most common inherited neuromuscular disorder, manifests as progressive muscle weakness and peripheral nerve defects. Dominant mutations in DNM2, encoding the large GTPase dynamin 2, result in CMT without any suggested therapeutic strategy. Different dominant mutations in DNM2 also cause centronuclear myopathy (CNM), and increasing BIN1 (amphiphysin 2), an endogenous modulator of DNM2, rescued CNM in mice. Here, we found that increasing BIN1 level exacerba...
