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最新文章

• Effects of binding partners on thermal reversion rates of photoswitchable molecules AI翻译
  作者：Reed, P. Maximilian M.; Jang, Jaewan; Woloschuk, Ryan M.; Reis, Jakeb; Hille, Jacques I. C.; Uppalapati, Maruti; Woolley, G. Andrew
  作者单位：University of Toronto; University of Saskatchewan
  摘要：The binding of photoswitchable molecules to partners forms the basis of many naturally occurring light-dependent signaling pathways and various photopharmacological and optogenetic tools. A critical parameter affecting the function of these molecules is the thermal half-life of the light state. Reports in the literature indicate that, in some cases, a binding partner can significantly influence the thermal half-life, while in other cases it has no effect. Here, we present a unifying framework ...
• In the activation of HPV- specific human B cells HPV-VLP vaccines mimic membrane- associated antigens AI翻译
  作者：Torgbor, Charles; Sohn, Haewon; Dizon, Brian L. P.; Mutic, Evan C.; George, Rachel; Kwak, Kihyuck; Akkaya, Munir; Ulker, Esin Bayrali; Traver, Maria; Brzostowski, Joseph; Galloway, Denise A.; Thompson, Cynthia D.; Cuburu, Nicolas; Schiller, John T.; Pierce, Susan K.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); Yonsei University; Yonsei University Health System; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; Fred Hutchinson Cancer Center; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
  摘要：B cell responses to membrane- presented antigens appear to be strongly favored over soluble antigens in vivo suggesting that vaccines that mimic membrane- presented antigens may be highly efficacious. We recently demonstrated that human B cell responses to membrane- associated but not to soluble antigens in vitro depended on the expression and activity of the plasma membrane mechanosensitive ion channel, Piezo1. Here, we provide evidence that the efficacy of the current human papillomavirus vi...
• Prediction of carbon nanostructure mechanical properties and the role of defects using machine learning AI翻译
  作者：Winetrout, Jordan J.; Li, Zilu; Zhao, Qi; Gaber, Landon; Unnikrishnan, Vinu; Varshney, Vikas; Xu, Yanxun; Wang, Yusu; Heinz, Hendrik
  作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of California System; University of California San Diego; Texas A&M University System; West Texas A&M University; United States Department of Defense; United States Air Force; Johns Hopkins University; University of California System; University of California San Diego
  摘要：Graphene- based nanostructures hold immense potential as strong and lightweight materials, however, their mechanical properties such as modulus and strength are difficult to fully exploit due to challenges in atomic- scale engineering. This study presents a database of over 2,000 pristine and defective nanoscale CNT bundles and other graphitic assemblies, inspired by microscopy, with associated stress-strain curves from reactive (IFF- R). These 3D structures, containing up to 80,000 atoms, ena...
• Archaeology and traversing America's pre- Columbian fault line AI翻译
  作者：Thomas, David Hurst
  作者单位：American Museum of Natural History (AMNH)
• Deep learning to quantify the pace of brain aging in relation to neurocognitive changes AI翻译
  作者：Yin, Chenzhong; Imms, Phoebe; Chowdhury, Nahian F.; Chaudhari, Nikhil N.; Ping, Heng; Wang, Haoqing; Bogdan, Paul; Irimia, Andrei
  作者单位：University of Southern California; University of Southern California; University of Southern California; University of Southern California; University of London; King's College London
  摘要：Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that summarizes cumulative neuroanatomic aging since birth. Thus, it conveys poorly recent or contemporaneous aging trends, which can be better quantified by the (temporal) pace P of brain aging. Many approaches to map P, however, rely on quantifying DNA methylation in whole-blood cells, which the bloo...
• Input-driven circuit reconfiguration in critical recurrent neural networks AI翻译
  作者：Magnasco, Marcelo O.
  作者单位：Rockefeller University
  摘要：Changing a circuit dynamically, without actually changing the hardware itself, is called reconfiguration, and is of great importance due to its manifold technological applications. Circuit reconfiguration appears to be a feature of the cerebral cortex, so understanding the dynamical principles underlying self-reconfiguration may prove of import to elucidate brain function. We present a very simple example of dynamical reconfiguration: a family of networks whose signal pathways can be switched ...
• TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice AI翻译
  作者：Kaneda, Yuki; Lu, Yonggang; Sun, Jiang; Shimada, Keisuke; Emori, Chihiro; Noda, Taichi; Koyano, Takayuki; Matsuyama, Makoto; Miyata, Haruhiko; Ikawa, Masahito
  作者单位：University of Osaka; University of Osaka; University of Osaka; Kumamoto University; Kumamoto University; University of Tokyo; University of Osaka; University of Osaka
  摘要：Sperm morphogenesis is a tightly regulated differentiation process, disruption of which leads to sperm malfunction and male infertility. Here, we show that Tex38 knockout (KO) male mice are infertile. Tex38 KO spermatids exhibit excess retention of residual cytoplasm around the head, resulting in abnormal sperm morphology with backward head bending. TEX38 interacts and colocalizes with ZDHHC19, a testis- enriched acyltransferase catalyzing protein S- palmitoylation, at the plasma membrane of s...
• Recessive genetic contribution to congenital heart disease in 5,424 probands AI翻译
  作者：Dong, Weilai; Jin, Sheng Chih; Sierant, Michael C.; Lu, Ziyu; Li, Boyang; Lu, Qiongshi; Morton, Sarah U.; Zhang, Junhui; Lopez-Giraldez, Francesc; Nelson-Williams, Carol; Knight, James R.; Zhao, Hongyu; Cao, Junyue; Mane, Shrikant; Gruber, Peter J.; Lek, Monkol; Goldmuntz, Elizabeth; Deanfield, John; Giardini, Alessandro; Mital, Seema; Russell, Mark; Gaynor, J. William; Cnota, James F.; Wagner, Michael; Srivastava, Deepak; Bernstein, Daniel; Porter Jr, George A.; Newburger, Jane; Roberts, Amy E.; Yandell, Mark; Yost, H. Joseph; Tristani-Firouzi, Martin; Kim, Richard; Seidman, Jonathan; Chung, Wendy K.; Gelb, Bruce D.; Seidman, Christine E.; Lifton, Richard P.; Brueckner, Martina
  作者单位：Yale University; Rockefeller University; Washington University (WUSTL); Washington University (WUSTL); Rockefeller University; Yale University; University of Wisconsin System; University of Wisconsin Madison; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Yale University; Yale University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of London; University College London; University of London; University College London; Great Ormond Street Hospital for Children NHS Foundation Trust; University of Toronto; Hospital for Sick Children (SickKids); University of Michigan System; University of Michigan; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University of California System; University of California San Francisco; The J David Gladstone Institutes; Stanford University; University of Rochester; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Utah System of Higher Education; University of Utah; Catholic University of America; Utah System of Higher Education; University of Utah; Cedars Sinai Medical Center; Harvard University; Harvard Medical School; Columbia University; Columbia University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute; Yale University
  摘要：Variants with large effect contribute to congenital heart disease (CHD). To date, recessive genotypes (RGs) have commonly been implicated through anecdotal ascertainment of consanguineous families and candidate gene-based analysis; the recessive contribution to the broad range of CHD phenotypes has been limited. We analyzed whole exome sequences of 5,424 CHD probands. Rare damaging RGs were estimated to contribute to at least 2.2% of CHD, with greater enrichment among laterality phenotypes (5....
• Dynamic and context- dependent keystone species effects in kelp forests AI翻译
  作者：Langendorf, Ryan E.; Estes, James A.; Watson, Jane C.; Kenner, Michael C.; Hatfield, Brian B.; Tinker, M. Tim; Waddle, Ellen; DeMarcheh, Megan L.; Doak, Daniel F.
  作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; United States Department of the Interior; United States Geological Survey; University of California System; University of California Santa Cruz; Vancouver Island University; University of Colorado System; University of Colorado Boulder; University System of Georgia; University of Georgia
  摘要：Sea otters are an iconic keystone predator that can maintain kelp forests by preying on grazing invertebrates such as sea urchins. However, the effects of sea otters on kelp forests vary over their geographic range. Here, we analyze two 30-y datasets on kelp forest communities during the reintroduction of sea otters along the west coast of Vancouver Island, BC, Canada, and around San Nicolas Island, CA. We developed a community model to estimate species interactions as dynamic rates, varying w...
• MUC5AC filaments illuminate the structural diversification of respiratory and intestinal mucins AI翻译
  作者：Haberman, Meital; Kamyshinsky, Roman; Reznik, Nava; Yeshaya, Noa; Khmelnitsky, Lev; Plender, Elizabeth G.; Eichler, Evan E.; Fass, Deborah
  作者单位：Weizmann Institute of Science; Weizmann Institute of Science; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
  摘要：Secreted mucins are multimegadalton glycoprotein polymers that share the function of protecting mucosal tissues but diversified for activities in different organs of the body. Structural studies of secreted mucins are complicated by the enormous sizes, flexibility, and complex supramolecular assembly modes of these glycoproteins. The two major respiratory mucins are MUC5AC and MUC5B. Here, we present structures of a large amino-terminal segment of MUC5AC in the form of helical filaments. These...