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最新文章

• Inhibition of amyloid beta oligomer accumulation by NU-9: A unifying mechanism for the treatment of neurodegenerative diseases AI翻译
  作者：Johnson, Elizabeth A.; Nowar, Raghad; Viola, Kirsten L.; Huang, Weijian; Zhou, Sihang; Bicca, Maira A.; Zhu, Wei; Kranz, Daniel L.; Klein, William L.; Silverman, Richard B.
  作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University
  摘要：Protein aggregation is a hallmark of neurodegenerative diseases, which connects these neuropathologies by a common phenotype. Various proteins and peptides form aggregates that are poorly degraded, and their ensuing pathological accumulation underlies these neurodegenerative diseases. Similarities may exist in the mechanisms responsible for the buildup of these aggregates. Therefore, therapeutics designed to treat one neurodegenerative disease may be beneficial to others. In ALS models, the co...
• Atomic ionization: sd energy imbalance and Perdew-Zunger self-interaction correction energy penalty in 3d atoms AI翻译
  作者：Maniar, Rohan; Shukla, Priyanka B.; Johnson, J. Karl; Jackson, Koblar A.; Perdew, John P.
  作者单位：Tulane University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Central Michigan University
  摘要：To accurately describe the energetics of transition metal systems, density functional approximations (DFAs) must provide a balanced description of s-and d-electrons. One measure of this is the sd transfer error, which has previously been defined as E(3dn-14s1) - E(3dn-24s2). Theoretical concerns have been raised about this definition due to its evaluation of excited-state energies using ground-state DFAs. A more serious concern appears to be strong correlation in the 4s2 configuration. Here, w...
• A cosmopolitan calcifying benthic foraminifera in agglutinated disguise as a geochemical recorder of coastal environments AI翻译
  作者：Sosnitsky, Tamara; Krekova, Vasilisa; Elisha, Bar; Sadekov, Aleksey; Torfstein, Adi; Holzmann, Maria; Li, Hua; Abramovich, Sigal; Ashckenazi-Polivoda, Sarit
  作者单位：Ben-Gurion University of the Negev; University of Western Australia; Hebrew University of Jerusalem; The Inter-University Institute for Marine Sciences; University of Geneva; Ben-Gurion University of the Negev
  摘要：Calcifying foraminifera from the orders Rotaliida and Miliolida are widely used geochemical proxies for recording paleoceanographic conditions, while agglutinated foraminifera are often overlooked since their tests are mostly composed of foreign particles. This study investigated the geochemical properties of Textularia agglutinans, cosmopolitan agglutinated benthic species from the order Textulariida which has exceptional inner calcareous test and is evolutionarily basal to Rotaliida. This st...
• Nanoscale distribution of bioactive ligands on biomaterials regulates cell mechanosensing through translocation of actin into the nucleus AI翻译
  作者：Liu, Xiaojing; Zhang, Man; Wang, Peng; Zheng, Kaikai; Wang, Xinlei; Xie, Wenyan; Pan, Xiaokai; Shen, Runjia; Liu, Ruili; Ding, Jiandong; Wei, Qiang
  作者单位：Fudan University; Sichuan University; Shandong University; Sichuan University; Harbin Institute of Technology; Sichuan University
  摘要：Cells respond to adhesive ligands such as arginine- glycine- aspartate (RGD) through integrins, which regulates cellular activities via influencing cytoskeleton assembly. Herein, we report that the nanoscale distribution of active ligands on biomaterials regulates cells through not only cytoplasmic tension but also nuclear tension. This is particularly related to translocation of actin into nucleus and highlighted in our interpretation of an abnormal phenomenon that large RGD nanospacing (>70 ...
• Cluster dynamical mean-field study of intra-unit-cell charge nematicity in hole-doped cuprates AI翻译
  作者：Kumar, Abhishek; Senechal, David; Tremblay, A. -M. S.
  作者单位：University of Sherbrooke; University of Sherbrooke
  摘要：Recent scanning-tunneling microscopy on hole-doped Bi2Sr2CaCu2O8, one of the materials of the cuprate family, finds a long-range ordered spontaneous splitting of the energy levels of oxygen orbitals inside the CuO2 unit cells [S. Wang etal., Nat. Mat. 23, 492-498 (2024)]. This spontaneous intra-unit-cell orbital ordering, also known as electronic nematicity, breaks C4 symmetry and is thought to arise from the Coulomb interaction (denoted by Vpp) between oxygen px and py electrons. In this work...
• Broken time- reversal symmetry in visual motion detection AI翻译
  作者：Wu, Nathan; Zhou, Baohua; Agrochao, Margarida; Clark, Damon A.
  作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Yale University
  摘要：Our intuition suggests that when a movie is played in reverse, our perception of motion at each location in the reversed movie will be perfectly inverted compared to the original. This intuition is also reflected in classical theoretical and practical models of motion estimation, in which velocity flow fields invert when inputs are reversed in time. However, here we report that this symmetry of motion perception upon time reversal is broken in real visual systems. We designed a set of visual s...
• The effect of salt additives on the glycine crystallization pathway revealed by studying one crystal nucleation at a time AI翻译
  作者：Cotting, Gabriel; Urquidi, Oscar; Besnard, Celine; Brazard, Johanna; Adachi, Takuji B. M.
  作者单位：University of Geneva; University of Geneva
  摘要：Molecular-level understanding of the early stage of crystallization remains a significant challenge. For a wide range of fundamental research and applications, it is of great importance to understand the mechanism of crystal polymorph selections in different solvents or in the presence of additives. We studied glycine crystallization in aqueous solution with or without the addition of sodium chloride (NaCl), one crystal nucleation at a time, using the recently developed single-crystal nucleati...
• Calcineurin goes to sleep AI翻译
  作者：Ye, Michael; Diering, Graham H.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
• Genomic divergence across the tree of life AI翻译
  作者：Hart, Rowan; Moran, Nancy A.; Ochman, Howard
  作者单位：University of Texas System; University of Texas Austin; University of Chicago; University of Texas System; University of Texas Austin
  摘要：Nucleotide sequence data are being harnessed to identify species, even in cases in which organisms themselves are neither in hand nor witnessed. But how genome-wide sequence divergence maps to species status is far from clear. While gene sequence divergence is commonly used to delineate bacterial species, its correspondence to established species boundaries has yet to be explored across eukaryotic taxa. Because the processes underlying gene flow differ fundamentally between prokaryotes and euk...
• Phase transitions in the rolling of irregular cylinders and spheres AI翻译
  作者：Qian, Daoyuan; Jung, Yeonsu; Mahadevan, L.
  作者单位：Harvard University; University of Cambridge; Harvard University; Harvard University
  摘要：When placed on an inclined plane, a perfect 2D disk or 3D sphere simply rolls down in a straight line under gravity. But how is the rolling affected if these shapes are irregular or random? Treating the terminal rolling speed as an order parameter, we show that there are qualitative transitions in the speed as a function of the dimension of the state space and inertia. We calculate the scaling exponents and the macroscopic lag time associated with the presence of first- and second-order transi...