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作者：Thangapandian, Sundar; Fakharzadeh, Ashkan; Moradi, Mahmoud; Tajkhorshid, Emad
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Arkansas System; University of Arkansas Fayetteville; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Removing glutamate from the synaptic cleft is vital for proper function of the brain. Excitatory amino acid transporters mediate this process by uptaking the neurotransmitter from the synaptic cleft back to the cell after its release. The archaeal homolog, GltPh, an aspartate transporter from Pyrococcus horikoshii, presents the best structurally characterized model for this family of transporters. In order to transport, GltPh undergoes elevator-like conformational changes between inward-facing...
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作者：Harel, Elhanan; Goren, Liran; Crouvi, Onn; Porat, Naomi; Qu, Tianyue; Ginat, Hanan; Shelef, Eitan
作者单位：Ben-Gurion University of the Negev; Geological Survey Israel; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Drainage divide migration alters the geometry of drainage basins, influencing the distribution of water, erosion, sediments, and ecosystems across Earth's surface. The rate of divide migration is governed by differences in erosion rates across the divide and is thus sensitive to spatiotemporal variations in tectonics and climate. However, established approaches for quantifying divide migration rates offer only indirect evidence for the motion of the divide and provide only migration rate avera...
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作者：Le, Trang Thi; Choi, Hong Il; Kim, Ji Won; Yun, Jin - Ho; Lee, Yoon Hyeok; Jeon, Eun Jung; Kwon, Kil Koang; Cho, Dae - Hyun; Choi, Dong - Yun; Park, Su - Bin; Yoon, Hyang Ran; Lee, Jeongmi; Sim, Eun Jeong; Lee, Yong Jae; Kim, Hee - Sik
作者单位：Korea Research Institute of Bioscience & Biotechnology (KRIBB); University of Science & Technology (UST); Sungkyunkwan University (SKKU); Korea Research Institute of Bioscience & Biotechnology (KRIBB); Korea Research Institute of Bioscience & Biotechnology (KRIBB); Korea Research Institute of Bioscience & Biotechnology (KRIBB); University of Science & Technology (UST)
摘要：Pathogen-derived nuclear localization signals (NLSs) enable vigorous nuclear invasion in the host by the virulence proteins harboring them. Herein, inspired by the robust nuclear import mechanism, we show that NLSs originating from the plant infection-associated Agrobacterium proteins VirD2 and VirE2 can be incorporated into the Cas9 system as efficient nuclear delivery enhancers, thereby improving the low gene-editing frequency in a model microalga, Chlamydomonas reinhardtii, caused by poor n...
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作者：Mayo, Alex Hiro; Deaconu, Darius-Alexandru; Masuda, Hidetoshi; Nii, Yoichi; Takahashi, Hidefumi; Belosludov, Rodion Vladimirovich; Ishiwata, Shintaro; Bahramy, Mohammad Saeed; Onose, Yoshinori
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作者：Kurnosov, Arkady; Lubchenko, Vassiliy
作者单位：University of Houston System; University of Houston; Wesleyan University; University of Houston System; University of Houston; University of Houston System; University of Houston
摘要：We argue that the dominant charge carrier in glassy semiconducting alloys is a compound particle in the form of an electron or hole bound to an intimate pair of topological lattice defects; the particle is similar to the polaron solution of the Su-Schrieffer-Heeger Hamiltonian. The spatial component of the density of states for these special polarons is determined by the length scale of spatial modulation of electronegativity caused by a separate set of standalone topological defects. The latt...
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作者：Patel, Dhruv; Roy, Avik; Kundu, Madhuchhanda; Jana, Malabendu; Luan, Chi-Hao; Gonzalez, Frank J.; Pahan, Kalipada
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作者：Liu, Shaoqing; Csillik, Ovidiu; Ordway, Elsa M.; Chang, Li - Ling; Longo, Marcos; Keller, Michael; Moorcroft, Paul R.
作者单位：Harvard University; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; Wake Forest University; University of California System; University of California Los Angeles; State University System of Florida; Florida State University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Agriculture (USDA); United States Forest Service
摘要：forest carbon storage and forest ecosystem responses to climate variability and change. Previous studies have analyzed environmental drivers influencing spatial variation in canopy height at landscape- to- regional scales; however, far less is known about the environmental determinants underlying regional and global scale variation in forest canopy height. Using the canopy height metrics products from Global Ecosystem instrument specifically designed to characterize forest structure, we analyz...
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作者：Eggertsen, Taylor G.; Travers, Joshua G.; Hardy, Elizabeth J.; Wolf, Matthew J.; McKinsey, Timothy A.; Saucerman, Jeffrey J.
作者单位：University of Virginia; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Virginia
摘要：Cardiomyocyte hypertrophy is a key clinical predictor of heart failure. High-throughput and AI-driven screens have the potential to identify drugs and downstream pathways that modulate cardiomyocyte hypertrophy. Here, we developed LogiRx, a logic-based mechanistic machine learning method that predicts drug-induced pathways. applied LogiRx to discover how drugs discovered in a previous compound screen attenuate cardiomyocyte hypertrophy. We experimentally validated LogiRx predictions in neonata...
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作者：Bermond, Baptiste; Wawrzynczak, Rafal; Zherlitsyn, Sergei; Kotte, Tommy; Helm, Toni; Gorbunov, Denis; Gu, Genda; Li, Qiang; Janasz, Filip; Meng, Tobias; Menges, Fabian; Felser, Claudia; Wosnitza, Joachim; Grushin, Adolfo; Carpentier, David; Gooth, Johannes; Galeski, Stanislaw
作者单位：Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Paris Cite; Max Planck Society; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); United States Department of Energy (DOE); Brookhaven National Laboratory; State University of New York (SUNY) System; Stony Brook University; University of Luxembourg; Technische Universitat Dresden; Technische Universitat Dresden; Technische Universitat Dresden; Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Institut National Polytechnique de Grenoble; Universite Grenoble Alpes (UGA); University of Bonn
摘要：Oscillations of conductance observed in strong magnetic fields are a striking manifestation of the quantum dynamics of charge carriers in solids. The large charge carrier density in typical metals sets the scale of oscillations in both electrical and thermal conductivity, which characterize the Fermi surface. In semimetals, thermal transport at low-charge carrier density is expected to be phonon dominated, yet several experiments observe giant quantum oscillations in thermal transport. This ra...
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作者：Di Caro, Valeria; Cesari, Paola; Sala, Francesco; Cattaneo, Luigi; Strick, Peter
作者单位：University of Verona; University of Verona; University of Trento; University of Trento
摘要：Visually guided grasping is a fundamental building block of animal behavior, the specific neural mechanisms of which remain poorly documented in the human brain. We have mapped the causal contribution of different brain parts to grasping behavior by studying the kinematic parameters of 33 patients with brain tumors, engaged in actions directed toward objects of different sizes. Using motion capture techniques, we analyzed the dynamics of grip aperture and wrist transport. Voxel-based lesion-sy...
