16期

最新文章

• Sex chromosome evolution in haploid plants: Microchromosomes, disappearing chromosomes, and giant chromosomes AI翻译
  作者：Charlesworth, Deborah
  作者单位：University of Edinburgh
  摘要：As in many diploid organisms with genetic sex determination, haploid-dominant organisms have also evolved sex chromosomes or extensive genomic regions that lack genetic recombination. An understanding of sex chromosome evolution should explain the causes and consequences of such regions in both diploids and haploids. However, haploids have been little studied, even though differences from sex chromosomes in diploids carry implications concerning the evolution of suppressed recombination in dip...
• Development of DPP-4-resistant CXCL9-Fc and CXCL10-Fc chemokines for effective cancer immunotherapy AI翻译
  作者：Lugassy, Jennie; Saleh, Noor Abdala -; Jarrous, Ghada; Turky, Abeer; Saidemberg, Daniel; Bahar, Gabriela Ridner -; Berger, Nir; On, Dana Bar -; Taura, Tetsuya; Wilson, David; Karin, Nathan; Steinman, Lawrence
  作者单位：Technion Israel Institute of Technology; Teva Pharmaceutical Industries; Teva Pharmaceutical Industries; Teva Pharmaceutical Industries USA
  摘要：CXCR3 is a chemokine receptor for three ligands: CXCL9, CXCL10, and CXCL11. Accumulating evidence, including data presented here, suggests that the interaction between CXCL9/CXCL10 and CXCR3 not only attracts CXCR3+ T cells but also cell killing. One of the homeostatic mechanisms that may limit this cycle is the cleavage of the two N- terminal amino acids of these chemokines by Dipeptidyl Peptidase IV (DPP- 4). The modified chemokines retain their ability to bind CXCR3 but no longer activate i...
• In the flow, how fluid dynamics shapes amyloid formation AI翻译
  作者：Willis, Leon F.; Brockwell, David J.; Radford, Sheena E.
  作者单位：University of Leeds
• Bidirectional disruption of GNAS transcripts causes broad methylation defects in pseudohypoparathyroidism type 1B AI翻译
  作者：Iwasaki, Yorihiro; Reyes, Monica; Ryabets-Lienhard, Anna; Gales, Barbara; Linglart, Agnes; Miller, Danny E.; Salusky, Isidro B.; Bastepe, Murat; Juppner, Harald
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Kitano Hospital; Children's Hospital Los Angeles; University of Southern California; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Antoine-Beclere - APHP; Hopital Universitaire Bicetre - APHP; Universite Paris Saclay; Seattle Children's Hospital; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：Pseudohypoparathyroidism type 1B (PHP1B) is a multihormone resistance disorder caused by aberrant GNAS methylation. Characteristic epigenetic changes at GNAS differentially methylated regions (DMRs), i.e., NESP, AS1, AS2, XL, and A/B, are associated with specific structural defects in different autosomal dominant PHP1B (AD-PHP1B) subtypes. However, mechanisms underlying abnormal GNAS methylation remain incompletely defined, largely because viable PHP1B mouse models are lacking. Using lymphobla...
• The pentameric chloride channel BEST1 is activated by extracellular GABA AI翻译
  作者：Pant, Swati; Tam, Stephanie W.; Long, Stephen B.
  作者单位：Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
  摘要：Bestrophin-1 (BEST1) is a chloride channel expressed in the eye and other tissues of the body. A link between BEST1 and the principal inhibitory neurotransmitter gamma- aminobutyric acid (GABA) has been proposed. The most appreciated receptors for extracellular GABA are the GABAB G-protein-coupled receptors and the pentameric GABAA chloride channels, both of which have fundamental roles in the central nervous system. Here, we demonstrate that BEST1 is directly activated by GABA. Through functi...
• CB-1 receptor agonist drastically changes oscillatory activity, defining active sleep AI翻译
  作者：Topchiy, Irina; Kocsis, Bernat
  作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; McLean Hospital
  摘要：Brain oscillations in different behavioral states are essential for cognition, and oscillopathies contribute to cognitive dysfunction in neuropsychiatric diseases. Cannabis-1 receptor (CB1-R) activation was reported to suppress theta and fast gamma activities in rats during waking exploration, and here, we show that cannabis fundamentally alters network activity during sleep as well. Prominent theta rhythm is present in rapid eye movement sleep (REMS), whereas fast oscillations appear as regul...
• RRM2B deficiency causes dATP and dGTP depletion through enhanced degradation and slower synthesis AI翻译
  作者：Awoyomi, Ololade Folajimi; Gorospe, Choco Michael; Das, Biswajit; Mishra, Pradeep; Sharma, Sushma; Diachenko, Olena; Nilsson, Anna Karin; Tran, Phong; Wanrooij, Paulina H.; Chabes, Andrei
  作者单位：Umea University
  摘要：Mitochondrial DNA (mtDNA) replication requires a steady supply of deoxyribonucleotides (dNTPs), synthesized de novo by ribonucleotide reductase (RNR). In non-dividing cells, RNR consists of RRM1 and RRM2B subunits. Mutations in RRM2B cause mtDNA depletion syndrome, linked to muscle weakness, neurological decline, and early mortality. The impact of RRM2B deficiency on dNTP pools in nondividing tissues remains unclear. Using a mouse knockout model, we demonstrate that RRM2B deficiency selectivel...
• Changes in agglomeration and productivity are poor predictors of inequality across the archaeological record AI翻译
  作者：Ortman, Scott G.; Bogaard, Amy; Munson, Jessica; Lawrence, Dan; Green, Adam S.; Feinman, Gary M.; Chirikure, Shadreck; Uhl, Johannes H.; Leyk, Stefan
  作者单位：University of Colorado System; University of Colorado Boulder; The Santa Fe Institute; University of Colorado System; University of Colorado Boulder; University of Oxford; Durham University; University of York - UK; University of York - UK; Field Museum of Natural History (Chicago); European Commission Joint Research Centre; EC JRC ISPRA Site; University of Colorado System; University of Colorado Boulder
  摘要：We address three basic issues regarding the long-term dynamics of inequality in society. First, we consider the interpretation of residence sizes in socioeconomic terms by comparing statistical patterns extracted from the Global Dynamics of Inequality (GINI) Project database with those from the 21st-century United States. Second, we examine the degree to which the size and productivity of human networks is systematically related to inequality. Finally, we investigate relationships between prod...
• Mapping global brain reconfigurations following local targeted manipulations AI翻译
  作者：Rabuffo, Giovanni; Lokossou, Houefa-Armelle; Li, Zengmin; Ziaee-Mehr, Abolfazl; Hashemi, Meysam; Quilichini, Pascale P.; Ghestem, Antoine; Arab, Ouafae; Esclapez, Monique; Verma, Parul; Raj, Ashish; Gozzi, Alessandro; Sorrentino, Pierpaolo; Chuang, Kai-Hsiang; Perles-Barbacaru, Teodora-Adriana; Viola, Angele; Jirsa, Viktor K.; Bernard, Christophe
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; University of Queensland; University of California System; University of California San Francisco; Istituto Italiano di Tecnologia - IIT; Center for Neuroscience & Cognitive System IIT
  摘要：Understanding how localized brain interventions influence whole-brain dynamics is essential for deciphering neural function and designing therapeutic strategies. Using longitudinal functional MRI datasets collected from mice, we investigated the effects of focal interventions, such as thalamic lesions and chemogenetic silencing of cortical hubs. We found that these local manipulations disrupted the brain's ability to sustain network-wide activity, leading to global functional connectivity (FC)...
• Force spectroscopy reveals membrane fluctuations and surface adhesion of extracellular nanovesicles impact their elastic behavior AI翻译
  作者：Stridfeldt, Fredrik; Pandey, Vikash; Kylhammar, Hanna; Gevari, Moein Talebian; Metem, Prattakorn; Agrawal, Vipin; Goergens, Andre; Mamand, Doste R.; Gilbert, Jennifer; Palmgren, Lukas; Holme, Margaret N.; Gustafsson, Oskar; El Andaloussi, Samir; Mitra, Dhrubaditya; Dev, Apurba
  作者单位：Royal Institute of Technology; Royal Institute of Technology; Nordic Institute for Theoretical Physics; Stockholm University; Uppsala University; Royal Institute of Technology; Stockholm University; Karolinska Institutet; Karolinska Institutet; Karolinska University Hospital; University of Duisburg Essen; Karolinska Institutet; Karolinska University Hospital; Chalmers University of Technology
  摘要：The elastic properties of nanoscale extracellular vesicles (EVs) are believed to influence their cellular interactions, thus having a profound implication in intercellular communication. However, accurate quantification of their elastic modulus is challenging due to their nanoscale dimensions and their fluid-like lipid bilayer. We show that the previous attempts to develop atomic force microscopy-based protocol are flawed as they lack theoretical underpinning as well as ignore important contri...