-
作者:Moreno-Spiegelberg, Pablo; Rietkerk, Max; Gomila, Damia
-
作者:Sahi, Chandan; Craig, Elizabeth Anne
-
作者:Huang, Yung-Hsin; Belk, Julia A.; Zhang, Ruochi; Weiser, Natasha E.; Chiang, Zachary; Jones, Matthew G.; Mischel, Paul S.; Buenrostro, Jason D.; Chang, Howard Y.
作者单位:Stanford University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute
摘要:Spatial epigenomics and multiomics can provide fine-grained insights into cellular states but their widespread adoption is limited by the requirement for bespoke slides and capture chemistries for each data modality. Here, we present SPatial assay for Accessible chromatin, Cell lineages, and gene Expression with sequencing (SPACE-seq), a method that utilizes polyadenine-tailed epigenomic libraries to enable facile spatial multiomics using standard whole transcriptome reagents. Applying SPACE-s...
-
作者:Kohler, Timothy A.; Bogaard, Amy; Ortman, Scott G.; Crema, Enrico R.; Chirikure, Shadreck; Cruz, Pablo; Green, Adam; Kerig, Tim; Mccoy, Mark D.; Munson, Jessica; Petrie, Cameron; Thompson, Amy E.; Birch, Jennifer; Quequezana, Gabriela Cervantes; Feinman, Gary M.; Fochesato, Mattia; Gronenborn, Detlef; Hamerow, Helena; Jin, Guiyun; Lawrence, Dan; Roscoe, Paul B.; Rosenstock, Eva; Erny, Grace K.; Kim, Habeom; Ohlrau, Rene; Hanson, J. W.; Navarro, Lane Fargher; Pailes, Matthew
作者单位:Washington State University; The Santa Fe Institute; University of Oxford; University of Colorado System; University of Colorado Boulder; University of Cambridge; University of York - UK; University of York - UK; University of Kiel; Leipzig University; State University System of Florida; Florida State University; University of Texas System; University of Texas Austin; University System of Georgia; University of Georgia; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Field Museum of Natural History (Chicago); Bocconi University; Johannes Gutenberg University of Mainz; Shandong University; Durham University; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono; University of Bonn; University of California System; University of California Berkeley; University of Oxford; University System of Ohio; Ohio State University; University of Oklahoma System; University of Oklahoma - Norman
摘要:Defining wealth broadly to include wealth in people, relational connections, and material possessions, we examine the prehistory of wealth inequality at the level of the residential units using the consistent proxy of Gini coefficients calculated across areas of contemporaneous residential units. In a sample of >1,100 sites and > 47,000 residential units spanning >10,000 y, persistent wealth inequality typically lags the onset of plant cultivation by more than a millennium. It accompanies land...
-
作者:Marcos, Marta; Amores, Angel; Agulles, Miguel; Robson, Jon; Feng, Xiangbo
作者单位:Universitat de les Illes Balears; Universitat de les Illes Balears; University of Reading; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science
摘要:Marine heatwaves are extreme climatic events consisting of persistent periods of warm ocean waters that have profound impacts on marine life. These episodes are becoming more intense, longer, and more frequent in response to anthropogenic global warming. Here, we provide a comprehensive and quantitative assessment on the role of global warming on marine heatwaves. To do so, we construct a counterfactual version observed global sea surface temperatures since 1940, corresponding to a stationary ...
-
作者:McDermott, Amy
-
作者:Nishiguchi, Daiki; Shiratani, Sora; Takeuchi, Kazumasa A.; Aranson, Igor S.
-
作者:Campbell, Erin E.; Sehyr, Zed Sevcikova; Pontecorvo, Elana; Cohen-Goldberg, Ariel; Emmorey, Karen; Caselli, Naomi
作者单位:Boston University; Chapman University System; Chapman University; Tufts University; California State University System; San Diego State University
摘要:The view that words are arbitrary is a foundational assumption about language, used to set human languages apart from nonhuman communication. We present here a study of the alignment between the semantic and phonological structure (systematicity) of and Spanish. Across all three languages, words that are semantically related are more likely to be phonologically related, highlighting systematic alignment between word form and word meaning. Critically, there is a significant effect of iconicity ...
-
作者:Koyanagi, Naoto; Hengphasatporn, Kowit; Kato, Akihisa; Nobe, Moeka; Takeshima, Kosuke; Maruzuru, Yuhei; Maenaka, Katsumi; Shigeta, Yasuteru; Kawaguchi, Yasushi
作者单位:University of Tokyo; University of Tokyo; University of Tokyo; University of Tsukuba; Hokkaido University; Hokkaido University; University of Tokyo
摘要:Herpesviruses encode conserved protein kinases (CHPKs) that target dependent kinase (CDK) phosphorylation sites; thus, they are termed kinases. Tyrosine 15 in the GxGxxG motifs of CDK1 and CDK2, whose tion down-regulates their catalytic activities, is conserved in the corresponding CHPKs. We found that CHPK UL13, the corresponding Tyr-162 in virus 2 (HSV-2), was phosphorylated in HSV-2-infected cells. Mutational HSV-2 UL13 Tyr-162 suggested that phosphorylation of UL13 Tyr-162 phosphorylation ...
-
作者:Li, Zhuowei; Paitandi, Rajendra Prasad; Tsutsui, Yusuke; Matsuda, Wakana; Nobuoka, Masaki; Chen, Bin; Ghosh, Samrat; Tanaka, Takayuki; Suda, Masayuki; Zhu, Tong; Kageyama, Hiroshi; Miyake, Yoshihiro; Shinokubo, Hiroshi; Takagi, Makito; Shimazaki, Tomomi; Tachikawa, Masanori; Suzuki, Katsuaki; Kaji, Hironori; Ando, Yasunobu; Ezaki, Takahiro; Seki, Shu
作者单位:Kyoto University; Kyoto University; Nagoya University; Yokohama City University; Kyoto University; University of Tokyo
摘要:Mimicking the interconvertible carbon allotropes of 2-dimensional (2D) graphene and 1-dimensional (1D) carbon nanotubes (CNTs), herein we report the in situ transformation of 2D it-conjugated covalent organic frameworks (COFs) sheet into 1D nanotubular structures via self-assembly the sheets at solvent interfaces. The facile roll-sheets self-assembly resulted in coaxial nanotubes with uniform cross-sectional diameter, which was realized for diazapyrene-based COFs but not for the corresponding ...