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作者：Wang, Qian; Kang, Yeon Hee; Hardtke, Christian S.
作者单位：University of Lausanne
摘要：Cellular signaling processes can elicit powerful responses and may need to be amplified to be efficient or dampened to prevent overstimulation. Therefore, they often involve autoregulatory feedbacks. Receptor kinase signaling pathways are abundant in plants, where they convey the presence of both exogenous and endogenous ligands. Among them, endogenous CLAVATA3/EMBRYO SURROUNDING REGION (CLE) peptide signaling acts in an inherently quantitative manner to determine the size of stem cell pools a...
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作者：Bongoni, Anjan K.; Kiss, Bence; McRae, Jennifer L.; Salvaris, Evelyn J.; Fisicaro, Nella; Muntz, Fenella; Nemeth, Balint Zoltan; Nagy, Zoltan Attila; Kocsis, Andrea; Gal, Peter; Cowan, Peter J.; Pal, Gabor
作者单位：St Vincent's Health; St Vincent's Hospital Melbourne; Eotvos Lorand University; St Vincent's Health; St Vincent's Hospital Melbourne; HUN-REN; HUN-REN Research Centre for Natural Sciences; University of Melbourne
摘要：Renal ischemia-reperfusion injury (IRI) is a common complication in several clinical scenarios including kidney transplantation. Mannan-binding lectin-associated serine proteinase (MASP)-2 is essential for activation of the complement lectin pathway, which has been implicated in the pathogenesis of renal IRI and therefore represents a potential therapeutic target. We developed a new, affinity-enhanced MASP-2 inhibitor, EVO24, by directed evolution of the D2 domain of human tissue factor pathwa...
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作者：Ducarme, Paul; Weber, Bart; van Hecke, Martin; Overvelde, Johannes T. B.
作者单位：AMOLF; AMOLF; University of Amsterdam; Leiden University; Leiden University - Excl LUMC; Eindhoven University of Technology
摘要：Mechanical snapping instabilities are leveraged by natural systems, metamaterials, and devices for rapid sensing, actuation, and shape changes, as well as to absorb impact. In all current forms of snapping, shapes deform in the same direction as the exerted forces, even though there is no physical law that dictates this. Here, we realize countersnapping mechanical structures that respond in the opposite way. In contrast to regular snapping, countersnapping manifests itself in a sudden shorteni...
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作者：Kohler, Timothy A.; Bogaard, Amy; Ortman, Scott G.
作者单位：Washington State University; The Santa Fe Institute; University of Oxford; University of Colorado System; University of Colorado Boulder
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作者：Lee, Wang - Pao; Chiang, Meng- Hsuan; Chao, Yi- Ping; Wang, Ying- Fong; Chen, Yan- Lin; Lin, Yu - Chun; Jenq, Shan- Yun; Lu, Jun - Wei; Fu, Tsai- Feng; Liang, Jia- Yu; Yang, Kai- Cing; Chang, Li- Yun; Wu, Tony; Wu, Chia - Lin
作者单位：Chang Gung University; Chang Gung University; Chang Gung University; National Tsing Hua University; Chang Gung University; National Chi Nan University; Chang Gung Memorial Hospital
摘要：Forming and forgetting memories shape our self- awareness and help us face future challenges. Therefore, understanding how memories are formed and how different memories interact in the brain is important. Previous studies have shown that thirsty flies sense humidity through ionotropic receptors, which help them locate water sources. Here, we showed that thirsty flies can be trained to associate specific odors with humidity to form a humidity memory that lasts for 30 min after association. Hum...
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作者：Schnupp, Jan W. H.; Buchholz, Sarah; Buck, Alexa N.; Budig, Henrike; Khurana, Lakshay; Rosskothen-Kuhl, Nicole
作者单位：City University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; University of Freiburg; University of Freiburg; University of Freiburg
摘要：Although cochlear implants (CIs) provide valuable auditory information to more than one million profoundly deaf patients, these devices remain inadequate in conveying fine timing cues. Early deaf patients in particular struggle to use interaural time differences (ITDs) for spatial hearing and auditory scene analysis. Why CI patients experience these limitations remains controversial. One possible explanation, which we investigate here, is that the stimulation by clinical CIs is inappropriate, ...
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作者：Yardeni, Tal; Olali, Arnold Z.; Chen, Hsiao-Wen; Wang, Liqing; Halton, Jeffrey A.; Zenab, Angi; Morrow, Ryan; Butic, Arrienne; Murdock, Deborah G.; Waymire, Katrina G.; MacGregor, Grant R.; Boursi, Ben; Beier, Ulf H.; Hancock, Wayne W.; Wallace, Douglas C.
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作者：Goncalves, Monica M.; Uday, Adwaith B.; Forrester, Taylor J. B.; Currie, S. Quinn W.; Kim, Angelina S.; Feng, Yue; Jitkova, Yulia; Velyvis, Algirdas; Harkness, Robert W.; Kimber, Matthew S.; Schimmer, Aaron D.; Zeytuni, Natalie; Vahidi, Siavash
作者单位：University of Guelph; McGill University; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; McGill University
摘要：Human ClpP protease contributes to mitochondrial protein quality control by degrading misfolded proteins. ClpP is overexpressed in cancers such as acute myeloid leukemia (AML), where its inhibition leads to the accumulation of damaged respiratory chain subunits and cell death. Conversely, hyperactivating ClpP with small- molecule activators, such as the recently discovered ONC201, disrupts mitochondrial protein degradation and impairs respiration in cancer cells. Despite its critical role in h...
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作者：Tili, Esmerina; Commisso, Teresa L.; Balatti, Veronica; Michaille, Jean - Jacques; Nuovo, Gerard J.; Croce, Carlo M.
作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute
摘要：Elevated miR-155 levels in B cell malignancies, such as CLL and DLBCL, correlate with increased aggressiveness of the disease. We recently reported that, in two different mouse models of miR-155-driven B cell malignancy, miR-155 targets and down-regulates transcripts encoding ICOSL, the ligand for the Inducible T cell costimulator (ICOS), thereby impairing the capacity of T lymphocytes to recognize and eliminate malignant cells. In report, we extend our previous findings to Human by showing th...
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作者：Bogaard, Amy; Cruz, Pablo; Fochesato, Mattia; Birch, Jennifer; Quequezana, Gabriela Cervantes; Chirikure, Shadreck; Crema, Enrico R.; Feinman, Gary M.; Green, Adam S.; Hamerow, Helena; Jin, Guiyun; Kerig, Tim; Lawrence, Dan; Mccoy, Mark D.; Munson, Jessica; Ortman, Scott G.; Petrie, Cameron A.; Roscoe, Paul
作者单位：University of Oxford; The Santa Fe Institute; Bocconi University; Bocconi University; Centre for Economic Policy Research - UK; University System of Georgia; University of Georgia; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Cambridge; Field Museum of Natural History (Chicago); University of York - UK; University of York - UK; Shandong University; University of Kiel; Durham University; State University System of Florida; Florida State University; University of Colorado System; University of Colorado Boulder; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono
摘要：Here, we assess the extent to which land use relating to food acquisition (farming, herding, foraging) and associated value regimes shaped past economic inequality. We consider the hypothesis that land-use systems in which production was limited by heritable material wealth (such as land) sustained higher levels of inequality than those limited by (free) human labor. We address this hypothesis using the Global Dynamics of InequalIty (GINI) project database, estimating economic inequalities bas...
