16期

最新文章

• Intraflagellar transport trains can switch rails and move along multiple microtubules in intact primary cilia AI翻译
  作者：Sun, Shufeng; Liang, Biqing; Koplas, Adam; Tikhonenko, Irina; Nachury, Maxence; Khodjakov, Alexey; Sui, Haixin
  作者单位：Wadsworth Center; State University of New York (SUNY) System; State University of New York (SUNY) System; University at Albany, SUNY; University of California System; University of California San Francisco
  摘要：Structural homeostasis and proper distributions of signaling molecules in cilia require a constant flow of cargoes carried by intraflagellar transport (IFT) trains in both anterograde and retrograde directions within the thin, long ciliary shafts. In the motile cilium framework, the nine microtubule doublets of the same length serve as the transportation rails, and a preferential association to the two subtubules of the microtubule doublets prevents collisions among the IFT trains that move in...
• MFRP is a molecular hub that organizes the apical membrane of RPE cells by engaging in interactions with specific proteins and lipids AI翻译
  作者：Tworak, Aleksander; Smidak, Roman; Menezes, Carolline Rodrigues; Du, Samuel W.; Suh, Susie; Choi, Elliot H.; Imanishi, Sanae S.; Dong, Zhiqian; Lewandowski, Dominik; Fong, Kristen E.; Grigorean, Gabriela; Pinto, Antonio F. M.; Xu, Qianlan; Skowronska-Krawczyk, Dorota; Blackshaw, Seth; Imanishi, Yoshikazu; Palczewski, Krzysztof
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of California System; University of California Davis; Salk Institute; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine
  摘要：Membrane frizzled-related protein (MFRP), present in the retinal pigment epithelium (RPE), is an integral membrane protein essential for ocular development and the normal physiology of the retina. Mutations in MFRP are associated with autosomal recessive nonsyndromic nanophthalmos, leading to severe hyperopia and early-onset retinitis pigmentosa. While several preclinical gene-augmentation and gene-editing trials hold promise for future therapies aimed at stopping degeneration and restoring re...
• Peripheral CD4+ T cells mediate the destructive effects of maternal separation on prefrontal myelination and cognitive functions AI翻译
  作者：Xiong, Rui; Hu, Yinyin; Wang, Menghan; Han, Ting; Hu, Yuying; Ma, Chaolin; Li, Baoming
  作者单位：Nanchang University; Nanchang University; Hangzhou Normal University
  摘要：Maternal separation (MS), a chronic stress event in early life, impairs myelination in the prefrontal cortex (PFC) and leads to PFC cognitive disorders. It remains largely unclear how such deficits are mediated. Here, we show that peripheral CD4+ T cells play an essential role in mediating the destructive effects of MS on medial prefrontal cortical (mPFC) myelination and cognitive functions in mice. Offspring mice with MS experience (MS mice) exhibited an increase in CD4+ T cells and xanthine ...
• Design principles for self- organization of mitotic spindle bipolarity AI翻译
  作者：Mitchison, Timothy J.
  作者单位：Harvard University; Harvard Medical School
• Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential AI翻译
  作者：Tuck, Jeremy R.; Dunlap, Lee E.; Khatib, Yara A.; Hatzipantelis, Cassandra J.; Novak, Sammy Weiser; Rahn, Rachel M.; Davis, Alexis R.; Mosswood, Adam; Vernier, Anna M. M.; Fenton, Ethan M.; Aarrestad, Isak K.; Tombari, Robert J.; Carter, Samuel J.; Deane, Zachary; Wang, Yuning; Sheridan, Arlo; Gonzalez, Monica A.; Avanes, Arabo A.; Powell, Noel A.; Chytil, Milan; Engel, Sharon; Fettinger, James C.; Jenkins, Amaya R.; Carlezon Jr, William A.; Nord, Alex S.; Kangas, Brian D.; Rasmussen, Kurt; Liston, Conor; Manor, Uri; Olson, David E.
  作者单位：University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; Salk Institute; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of California System; University of California Davis; University of California System; University of California Davis; Harvard University; Harvard University Medical Affiliates; McLean Hospital; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California San Diego; University of California System; University of California Davis
  摘要：Decreased dendritic spine density in the cortex is a key pathological feature of neuropsychiatric diseases including depression, addiction, and schizophrenia (SCZ). Psychedelics possess a remarkable ability to promote cortical neuron growth and increase spine density; however, these compounds are contraindicated for patients with SCZ or a family history of psychosis. Here, we report the molecular design and de novo total synthesis of (+)-JRT, a structural analogue of lysergic acid diethylamide...
• Elevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism AI翻译
  作者：Warden, Anna S.; Sharma, Nishant; Hutchens, Steven; Liu, Chunyi; Haggerty, Noah R.; Gurol, Kerem C.; Jursa, Thomas; Smith, Donald R.; Mayfield, Roy Dayne; Mukhopadhyay, Somshuvra
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of California System; University of California Santa Cruz; Chongqing Medical University; Chongqing Medical University
  摘要：Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and environmental Mn overexposure is a global public health problem. To address this, here we combined unbiased transcriptomics and metabolomics with functional studies in a mouse model of human environmen...