16期

最新文章

• War both reduced and increased inequality over the past 10,000 years AI翻译
  作者：McCoy, Mark D.; Birch, Jennifer; Chirikure, Shadreck; Cruz, Pablo; Green, Adam S.; Gronenborn, Detlef; Lawrence, Dan; Roscoe, Paul
  作者单位：State University System of Florida; Florida State University; University System of Georgia; University of Georgia; University of Oxford; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of York - UK; University of York - UK; Durham University; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono
  摘要：Scholars are divided over the long-term effects that war has had on inequality. Some have argued that conflict grows the gap between rich and poor. Others counter that violence levels out wealth differences. The GINI Project Database is a large global sample of archaeological data on house sizes created to investigate what factors influenced economic inequality over long periods of time, including warfare. Over 39,000 individual residential units were coded as having fortifications present or ...
• A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice AI翻译
  作者：Millera, Bradley R.; Gonzaga-Jaureguic, Claudia; Brigattie, Karlla W.; de Jonga, Job; Breeseg, Robert S.; Ko, Seungyeon; Puffenbergere, Erik G.; Van Houtc, Cristopher; Younge, Millie; Lunah, Victor M.; Staplesc, Jeffrey; First, Michael B.; Gregoirea, Hilledna J.; Dworka, Andrew J.; Pefanisg, Evangelos; Mccarthyc, Shane; Brydges, Susannah; Rojasg, Jose; Yec, Bin; Stahlc, Eli; Di Gioiac, Silvio Alessandro; Hena, Rene; Elwoodi, Kevin; Rosoklijaa, Gorazd; Lic, Dadong; Mellisg, Scott; Careyi, David; Crollg, Susan D.; Overtonc, John D.; Macdonaldg, Lynn E.; Economidesc, Aris N.; Shuldinerc, Alan R.; Chuhmaf, Nao; Rayportf, Stephen; Aminj, Najaf; Kushnera, Steven A.; Haberg, Nicole Alessandri-; Markx, Sander; Strauss, Kevin A.
  作者单位：Columbia University; New York State Psychiatry Institute; Regeneron; Universidad Nacional Autonoma de Mexico; New York State Psychiatry Institute; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Geisinger Health System; Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC; University of Massachusetts System; University of Massachusetts Worcester; University of Massachusetts System; University of Massachusetts Worcester
  摘要：Major depressive disorder (MDD) is a leading cause of disability worldwide. Risk for MDD is heritable, and the genetic structure of founder populations enables investigation of rare susceptibility alleles with large effect. In an extended Old Order Mennonite family cohort, we identified a rare missense variant in GPR156 (c.1599G>T, p.Glu533Asp) associated with a two-fold increase in the relative risk of MDD. GPR156 is an orphan G protein-coupled receptor localized in the medial habenula, a reg...
• Dynamic coexistence driven by physiological transitions in microbial communities AI翻译
  作者：Narla, Avaneesh V.; Hwa, Terence; Murugan, Arvind
  作者单位：University of California System; University of California San Diego; University of Chicago
  摘要：Microbial ecosystems are commonly modeled by fixed interactions between species in steady exponential growth states. However, microbes in exponential growth often modify their environments so strongly that they are forced out of the growth state into stressed, nongrowing states. Such dynamics are typical of ecological succession in nature and serial-dilution cycles in the laboratory. Here, we introduce a phenomenological model, the Community State Model, to gain insight into the dynamic coexis...
• 100 generations of wealth equality after the Neolithic transitions AI翻译
  作者：Kerig, Tim; Crema, Enrico R.; Birch, Jennifer; Feinman, Gary M.; Green, Adam S.; Gronenborn, Detlef; Lawrence, Dan; Petrie, Cameron A.; Roscoe, Paul; Thompson, Amy E.; Kohler, Timothy A.
  作者单位：University of Kiel; Leipzig University; University of Cambridge; University System of Georgia; University of Georgia; Field Museum of Natural History (Chicago); University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of York - UK; University of York - UK; Durham University; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono; University of Texas System; University of Texas Austin; Washington State University; The Santa Fe Institute
  摘要：From Rousseau onward, scholars have identified the transition to sedentary agriculture as crucial to the history of wealth inequality. Here, using the GINI project's global database on disparities in residential size, we examine the effects of important innovations in plant cultivation, animal husbandry, and traction on wealth inequality. Over a series of regional case studies, we find no evidence of major changes in residential disparity before or after these technological innovations became ...
• Reconsidering indoor residual spraying coverage targets: A retrospective analysis of high-resolution programmatic malaria control data AI翻译
  作者：Galick, David S.; Vaz, Liberato Motobe; Ondo, Lucas; Iyanga, Marcos Mbulito; Bikie, Faustino Etoho Ebang; Avue, Restituto Mba Nguema; Donfack, Olivier Tresor; Eyono, Jeremias Nzamio Mba; Mifumu, Teresa Ayingono Ondo; Hergott, Dianna E. B.; Phiri, Wonder P.; Smith, David L.; Guerra, Carlos A.; Guerra, Guillermo A.; Hemingway, Janet
  作者单位：Institute for Health Metrics & Evaluation; University of Washington; University of Washington Seattle
  摘要：Indoor residual spraying (IRS) is one of the core vector control interventions available to malaria control programs. Normative and scientific guidance has long held that very high IRS coverage (at least 80 to 85% houses sprayed) is necessary to provide community protection, but there is little evidence backing these recommendations, in large part due to the operational and ethical concerns that conducting appropriate trials of differing IRS coverage levels would raise. The present study lever...
• Functional redundancy in the toxic pathway of Bt protein Cry1Ab, but not Cry1Fa, against the Asian corn borer AI翻译
  作者：Wang, Xingliang; Yue, Yujin; Zhai, Yuqian; Wang, Falong; Zhuang, Xuna; Wu, Shuwen; Yang, Yihua; Tabashnik, Bruce E.; Wu, Yidong
  作者单位：Nanjing Agricultural University; University of Arizona
  摘要：Crops genetically engineered to produce insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) have been used extensively to control some major crop pests, but their benefits decrease when pests evolve resistance. Better understanding of the genetic basis of resistance is needed to effectively monitor, manage, and counter pest resistance to Bt crops. Resistance to Bt proteins in at least 11 species of Lepidoptera, including many important crop pests, is associated with naturally ...
• Combining exchangeable P- values (vol 122, e2410849122, 2025) AI翻译
  作者：Gasparin, Matteo; Wang, Ruodu; Ramdas, Aaditya
• Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin AI翻译
  作者：Ishimoto, Naito; Wong, Joshua L. C.; He, Shan; Shirran, Sally; Wright-Paramio, Olivia; Seddon, Chloe; Singh, Nanki; Balsalobre, Carlos; Sonani, Ravi R.; Clements, Abigail; Egelman, Edward H.; Frankel, Gad; Beis, Konstantinos
  作者单位：UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; Imperial College London; University of St Andrews; University of Barcelona; University of Virginia
  摘要：Conjugation, the major driver of the spread of antimicrobial resistance genes, relies on a conjugation pilus for DNA transfer. Conjugative pili, such as the F-pilus, are dynamic tubular structures, composed of a polymerized pilin, that mediate the initial donor-recipient interactions, a process known as mating pair formation (MPF). IncH are low-copy-number plasmids, traditionally considered broad host range, which are found in bacteria infecting both humans and animals. The reference IncHI1 pl...
• SNX10 deficiency impairs sensitivity to anti-HER2 antibody-drug conjugates via altering HER2 trafficking in HER2-positive breast cancer AI翻译
  作者：Chen, Yu-Fei; Zhang, Qing-Hua; Zhang, Zhong-Wei; Zhou, Yu-Jie; Liu, Cui-Cui; Shao, Zhi-Ming; Yu, Ke-Da
  作者单位：Fudan University; Fudan University; Fudan University
  摘要：Antibody-drug conjugates (ADCs) are a rapidly developing therapeutic approach in cancer treatment that has shown remarkable efficacy in breast cancer. Despite the promising efficacy of anti-HER2 ADCs, many patients are still experiencing disease progression under treatment. Here, by analyzing the transcriptome data from patient-derived organoid models, I-SPY2 trial, and resistant cell lines, we identified that SNX10 deficiency conferred anti-HER2 ADCs resistance in HER2-positive breast cancer....
• Sleep homeostasis in lizards and the role of the cortex AI翻译
  作者：Hatori, Sena; Yamaguchi, Sho T.; Kobayashi, Riho; Okamoto, Kazuki; Zhou, Zhiwen; Kotake, Koki T.; Matsui, Futaba; Hioki, Hiroyuki; Norimoto, Hiroaki
  作者单位：Nagoya University; Hokkaido University; Juntendo University
  摘要：Slow-wave sleep (SWS) and rapid eye movement sleep are the two primary components of electrophysiological sleep (e-sleep) in mammals and birds. Slow waves in the cortex not only characterize SWS but are also used as biological markers for sleep homeostasis, given their rebound after sleep deprivation (SD). Recently, it has been reported that the Australian dragon Pogona vitticeps exhibits a two-stage sleep pattern in the dorsal ventricular ridge (DVR), which includes a homologue of the mammali...