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作者：Zhang, Huimin; Li, Youhang; Shah, Sameer Bikram; Li, Shibo; Li, Qingrong; Oaks, Joshua; Lv, Tinghong; Shi, Linda Z.; Wang, Hailong; Wang, Dong; Wu, Xiaohua
作者单位：Scripps Research Institute; Capital Normal University; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：The MRE11/RAD50/NBS1 (MRN) complex plays multiple roles in the maintenance of genome stability. MRN is associated with replication forks to preserve fork integrity and is also required for end resection at double-strand breaks (DSBs) to facilitate homologous recombination (HR). The critical need for proper control of the MRE11 nuclease activity is highlighted by the extensive nascent strand DNA degradation driven by MRE11 in BRCA-deficient cells, leading to genome instability and increased sen...
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作者：Dorantes-Gilardi, Rodrigo; Ivey, Kerry L.; Costa, Lauren; Matty, Rachael; Cho, Kelly; Gaziano, John Michael; Barabasi, Albert-Laszlo
作者单位：Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; Northeastern University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital
摘要：Biobanks advance biomedical and clinical research by collecting and offering data and biological samples for numerous studies. However, the impact of these repositories varies greatly due to differences in their purpose, scope, governance, and data collected. Here, we computationally identified 2,663 biobanks and their textual mentions in 228,761 scientific articles, 16,210 grants, 15,469 patents, 1,769 clinical trials, and 9,468 public policy documents, helping characterize the academic commu...
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作者：Ravindran, Sandeep
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作者：Shen, Di; Zhao, Qun; Zhang, Huaiyue; Wu, Ci; Jin, Hao; Guo, Kun; Sun, Rui; Guo, Hengke; Zhao, Qi; Feng, Huan; Dong, Xuepeng; Gao, Zhenming; Zhang, Lihua; Liu, Yu
作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Dalian Medical University
摘要：Most bioorthogonal photouncaging reactions preferentially occur in polar environments to accommodate biological applications in the aqueous cellular milieu. However, they are not precisely designed to chemically adapt to the diverse microenvironments of the cell. Herein, we report a hydrophobic photouncaging reaction with tailored photolytic kinetics toward solvent polarity. Structural modulations of the aminobenzoquinone-based photocage reveal the impact of cyclic ring size, steric substituen...
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作者：Huang, Tingting; Xie, Wanqing; Guo, Yunlu; Li, Yan; Yin, Jiemin; Jin, Xia; Ma, Yezhi; Zhang, Yueman; Huang, Dan; Chen, Caiyang; Wang, Xin; Zhu, Ziyu; Gan, Yu; Liesz, Arthur; Yu, Weifeng; Yuan, Junying; Li, Peiying
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; University of Munich; University of Munich; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS
摘要：Neutrophils are the most abundant circulating leukocyte population that play critical roles in neuroinflammation following central nervous system (CNS) injury. CD177, a glycoprotein on neutrophils, is emerging as an important immune regulator which can fundamentally affect multiple human inflammatory diseases. However, the role and regulatory mechanism of CD177 glycobiology of neutrophils in neuroinflammation remain elusive. Here, we show that CD177+neutrophils expand significantly and infiltr...
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作者：Shen, Yuan; O'Byrne, Jeremy; Schoenit, Andreas; Maitra, Ananyo; Mege, Rene-Marc; Voituriez, Raphael; Ladoux, Benoit
作者单位：Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; CY Cergy Paris Universite; Centre National de la Recherche Scientifique (CNRS); University of Erlangen Nuremberg
摘要：The collective motion of epithelial cells is a fundamental biological process which plays a significant role in embryogenesis, wound healing, and tumor metastasis. While it has been broadly investigated for over a decade both in vivo and in vitro, large-scale coherent flocking phases remain underexplored and have so far been mostly described as fluid. In this work, we report an additional mode of large-scale collective motion for different epithelial cell types in vitro with distinctive featur...
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作者：Mitchison, Timothy J.
作者单位：Harvard University; Harvard Medical School
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作者：Tuck, Jeremy R.; Dunlap, Lee E.; Khatib, Yara A.; Hatzipantelis, Cassandra J.; Novak, Sammy Weiser; Rahn, Rachel M.; Davis, Alexis R.; Mosswood, Adam; Vernier, Anna M. M.; Fenton, Ethan M.; Aarrestad, Isak K.; Tombari, Robert J.; Carter, Samuel J.; Deane, Zachary; Wang, Yuning; Sheridan, Arlo; Gonzalez, Monica A.; Avanes, Arabo A.; Powell, Noel A.; Chytil, Milan; Engel, Sharon; Fettinger, James C.; Jenkins, Amaya R.; Carlezon Jr, William A.; Nord, Alex S.; Kangas, Brian D.; Rasmussen, Kurt; Liston, Conor; Manor, Uri; Olson, David E.
作者单位：University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; Salk Institute; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of California System; University of California Davis; University of California System; University of California Davis; Harvard University; Harvard University Medical Affiliates; McLean Hospital; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California San Diego; University of California System; University of California Davis
摘要：Decreased dendritic spine density in the cortex is a key pathological feature of neuropsychiatric diseases including depression, addiction, and schizophrenia (SCZ). Psychedelics possess a remarkable ability to promote cortical neuron growth and increase spine density; however, these compounds are contraindicated for patients with SCZ or a family history of psychosis. Here, we report the molecular design and de novo total synthesis of (+)-JRT, a structural analogue of lysergic acid diethylamide...
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作者：Warden, Anna S.; Sharma, Nishant; Hutchens, Steven; Liu, Chunyi; Haggerty, Noah R.; Gurol, Kerem C.; Jursa, Thomas; Smith, Donald R.; Mayfield, Roy Dayne; Mukhopadhyay, Somshuvra
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of California System; University of California Santa Cruz; Chongqing Medical University; Chongqing Medical University
摘要：Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and environmental Mn overexposure is a global public health problem. To address this, here we combined unbiased transcriptomics and metabolomics with functional studies in a mouse model of human environmen...
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作者：Fountain, Adam J.; Waller, Natalie J. E.; Cheung, Chen - Yi; Jowsey, William; Chrisp, Michael T.; Troll, Mark; Edelstein, Paul H.; Cook, Gregory M.; Mcneil, Matthew B.; Ramakrishnan, Lalita
作者单位：MRC Laboratory Molecular Biology; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of Otago; Queensland University of Technology (QUT)
摘要：Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant tuberculosis. However, its clinical use is threatened by the emergence of bedaquiline-resistant strains of Mycobacterium tuberculosis. Bedaquiline targets mycobacterial ATP synthase but the predominant route to clinical bedaquiline resistance is via upregulation of the MmpS5L5 efflux pump due to mutations that inactivate the transcriptional repressor Rv0678. Here, we show that the MmpS5L5 efflux pump reduces su...
