18期

最新文章

• Synthesized dispersion- engineered elastic metasurfaces for achromatic focusing and harvesting across the audible to ultrasound ranges AI翻译
  作者：Lee, Geon; Choi, Wonjae; Seung, Hong Min; Kim, Seokwoo; Rho, Junsuk
  作者单位：Pohang University of Science & Technology (POSTECH); Korea Research Institute of Standards & Science (KRISS); University of Science & Technology (UST); Pohang University of Science & Technology (POSTECH); Pohang University of Science & Technology (POSTECH)
  摘要：Metasurfaces have garnered significant attention for unnatural abilities to modulate waves across various physics domains, including elastics. However, existing elastic metasurfaces are limited to narrowband operations due to chromatic aberrations; moreover, these exhibit highly discrete phase profiles due to the empty spaces required for each meta- atom to function as an individual waveguide. Herein, to address these, we propose a synthesized dispersion engineering that compensates for higher...
• Increased flood exposure in the Pacific Northwest following earthquake-driven subsidence and sea-level rise AI翻译
  作者：Dura, Tina; Chilton, William; Small, David; Garner, Andra J.; Hawkes, Andrea; Melgar, Diego; Engelhart, Simon E.; Staisch, Lydia M.; Witter, Robert C.; Nelson, Alan R.; Kelsey, Harvey M.; Allan, Jonathan C.; Bruce, David; Depaolis, Jessica; Priddy, Michael; Briggs, Richard W.; Weiss, Robert; La Selle, Seanpaul; Willis, Michael; Horton, Benjamin P.
  作者单位：Virginia Polytechnic Institute & State University; University of Oregon; Rowan University; University of North Carolina; University of North Carolina Wilmington; Durham University; United States Department of the Interior; United States Geological Survey; United States Department of the Interior; United States Geological Survey; United States Department of the Interior; United States Geological Survey; California State University System; California State Polytechnic University Pomona; United States Department of the Interior; United States Geological Survey; City University of Hong Kong; Nanyang Technological University; Nanyang Technological University
  摘要：Climate-driven sea-level rise is increasing the frequency of coastal flooding worldwide, exacerbated locally by factors like land subsidence from groundwater and resource extraction. However, a process rarely considered in future sea-level rise scenarios is sudden (over minutes) land subsidence associated with great (>M8) earthquakes, which can exceed 1 m. Along the Washington, Oregon, and northern California coasts, the next great Cascadia subduction zone earthquake could cause up to 2 m of s...
• Massive mutagenesis reveals an incomplete amyloid motif in Bri2 that turns amyloidogenic upon C-terminal extension AI翻译
  作者：Martin, Mariano; Bolognesi, Benedetta
  作者单位：Barcelona Institute of Science & Technology; University of Barcelona; Institut de Bioenginyeria de Catalunya
  摘要：Stop-loss mutations cause over twenty different diseases. The effects of stop-loss mutations can have multiple consequences that are, however, hard to predict. Stop-loss in ITM2B/BRI2 results in C-terminal extension of the encoded protein and, upon furin cleavage, in the production of two 34 amino acid long peptides, ADan and ABri, that accumulate as amyloids in the brains of patients affected by familial Danish and British Dementia. To systematically explore the consequences of Bri2 C-termina...
• Late Cretaceous community structure changed before the asteroid AI翻译
  作者：Polly, P. David
  作者单位：University of Helsinki; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
• Gag proteins encoded by endogenous retroviruses are required for zebrafish development AI翻译
  作者：Chang, Ni-Chen; Wells, Jonathan N.; Wang, Andrew Y.; Schofield, Phillip; Huang, Yi-Chia; Truong, Vinh H.; Simoes-Costa, Marcos; Feschotte, Cedric
  作者单位：Cornell University; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE- derived sequences repurposed for organismal function. The process by which TEs become coopted remains obscure because most cases involve ancient, transpositionally inactive elements. Reports of active TEs serving beneficial functions are scarce and often contentious due to difficulties in manipulating repetitive sequences. Here, we show that recently active TEs in zebrafish encode products critical fo...
• A zinc transporter drives glioblastoma progression via extracellular vesicles- reprogrammed microglial plasticity AI翻译
  作者：Zhang, Liyang; Yang, Jingxuan; Zhou, Zhijun; Ren, Yu; Chen, Bo; Tang, Anliu; Zhang, Kailiang; Li, Chuntao; Zhou, Hongshu; Fung, Kar - Ming; Xu, Chao; Kang, Chunsheng; Battiste, James D.; Bronze, Michael S.; Houchen, Courtney W.; Liu, Zhixiong; Dunn, Ian F.; Cavenee, Webster K.; Li, Min
  作者单位：University of Oklahoma - Norman; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; Central South University; Central South University; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; Tianjin Medical University; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of California System; University of California San Diego
  摘要：Glioblastoma (GBM) is the most aggressive form of brain cancer, with limited therapeutic options. While microglia contribute to GBM progression, the mechanisms by which they foster a protumorigenic immune environment remain poorly understood. We identify the zinc transporter Zrt-And Irt-Like Protein 4 (ZIP4) as a pivotal regulator of the GBM immune landscape. In orthotopic mouse models, ZIP4 drives tumor growth and behavioral changes. Mechanistically, ZIP4 modulates microglial plasticity throu...
• Popping the hood of muscle motors using time- resolved, small- angle X- ray diffraction AI翻译
  作者：Hessel, Anthony L.
  作者单位：University of Munster
• Divergence in children's gender stereotypes and motivation across STEM fields AI翻译
  作者：Master, Allison; Meltzoff, Andrew N.; Tang, Daijiazi; Cheryan, Sapna
  作者单位：University of Houston System; University of Houston; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Michigan System; University of Michigan
  摘要：STEM disciplines are traditionally stereotyped as being for men and boys. However, in two preregistered studies of Grades 1 to 12 students in the United States (N = 2,765), we find a significant divergence in students' gender stereotypes about different STEM fields. Gender stereotypes about computer science and engineering more strongly favored boys than did gender stereotypes about math and science. These patterns hold across genders, intersections of gender and race/ethnicity, and two geogra...
• Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1 AI翻译
  作者：Ong, Seow Theng; Nam, Young - Woo; Nasburg, Joshua A.; Ramanishka, Alena; Ng, Xuan Rui; Zhuang, Zhong; Goay, Stephanie Shee Min; Nguyen, Hai M.; Singh, Latika; Singh, Vikrant; Rivera, Alicia; Eyster, M. Elaine; Xu, Yang; Alper, Seth L.; Wulff, Heike; Zhang, Miao; Chandy, K. George
  作者单位：Nanyang Technological University; Chapman University System; Chapman University; University of California System; University of California Davis; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory
  摘要：The 1,4-dihydropyridines, drugs with well-established bioavailability and toxicity profiles, have proven efficacy in treating human hypertension, peripheral vascular disorders, and coronary artery disease. Every 1,4-dihydropyridine in clinical use blocks L-type voltage-gated calcium channels. We now report our development, using selective optimization of a side activity (SOSA), of a class of 1,4-dihydropyridines that selectively and potently inhibit the intermediate-conductance calcium-activat...
• Global modulation of gene expression and transcriptome size in aneuploid combinations of maize AI翻译
  作者：Yang, Hua; Brennan, Vincent; Gao, Zhi; Liu, Jian; Boadu, Frimpong; Cheng, Jianlin; Birchler, James A.
  作者单位：University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia
  摘要：Genomic imbalance refers to the more severe phenotypic consequences of changing a single chromosome compared to changing the whole genomic set. Previous genomic imbalance studies in maize have identified gene expression modulation in aneuploids of single chromosome arms. Here, the modulation of gene expression in more complex aneuploids, e.g., monosomy of one chromosome arm and trisomy of another was examined to determine the extent that combination aneuploids were additive, multiplicative, or...