Toward quantitative X-ray elastography of coronary arteries using flexural pulse waves

• 成果类型: Article
• 署名作者: Gregoire, Sibylle; Laloy-Borgna, Gabrielle; Rouviere, Olivier; Giammarinaro, Bruno; Catheline, Stefan; Weitz, David
• 署名单位: Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Delft University of Technology; Universite Claude Bernard Lyon 1; CHU Lyon
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-13134
• DOI: 10.1073/pnas.2419060122
• 发表日期: 2025-05-06
• 关键词: visualization; wall

摘要

Dynamic elastography uses an imaging system to visualize the propagation of elastic waves, the speed of which is directly related to the elasticity felt by palpation. Very few studies have focused on X-ray elastography because of the technical challenges it poses: a planar image of an integration volume at a very slow sampling rate. We demonstrate that tracking a slow elastic wave guided along a one-dimensional structure could provide a possible solution. The recently discovered flexural pulse wave, which is naturally generated by heartbeats and propagates along arteries, is the perfect candidate for X-ray elastography. As it reflects the cardiovascular health of patients, arterial elasticity is a biomarker of high clinical interest. We first validate the method by measuring the elasticity in artery phantoms using X-ray. We then move on to data obtained in vivo on coronary arteries during a routine angiography examination. During coronary angiography, a catheter is used to inject an X-ray contrast dye into the patient's aorta. X-rays are then taken as the dye spreads through the coronary arteries. It shows the movement of the coronary arteries for a few seconds and provides an opportunity to follow the natural flexural pulse waves. The obtained Young's moduli for two patients are E = 38 +/- 30 kPa and E = 36 +/- 28 kPa, respectively. These preliminary results are expected to pave the way for X-ray elastography.