23期

最新文章

• Resilience of deep aquifer microbial communities to seasonal hydrological fluctuations AI翻译
  作者：Giroud, Sebastien; Deng, Longhui; Lever, Mark A.; Schilling, Oliver S.; Kipfer, Rolf
  作者单位：Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); Swiss Federal Institutes of Technology Domain; ETH Zurich; Shanghai Jiao Tong University; University of Texas System; University of Texas Austin; University of Basel; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：The influence of seasonal variations in temperature and precipitation on subsurface biogeochemical processes remains poorly understood. In the Lavey-les-Bains thermal system in the Swiss Alps, annual variations in electrical conductivity are observed to depths of 500 m, suggesting a potential link to surface environmental changes. Here we show, through year-round analyses of stable water isotopes, noble gases, and conductivity, that seasonally varying contributions of shallow groundwater from ...
• Anthropogenic iron alters the spring phytoplankton bloom in the North Pacific transition zone AI翻译
  作者：Hawco, Nicholas J.; Conway, Tim M.; Coesel, Sacha N.; Barone, Benedetto; Seelen, Emily A.; Yang, Shun - Chung; Bundy, Randelle M.; Gonzalez, Paulina; Bian, Xiaopeng; Sieber, Matthias; Lanning, Nathan T.; Fitzsimmons, Jessica N.; Foreman, Rhea K.; Konig, Daniela; Groussman, Mora J.; Allen, James G.; Juranek, Lauren W.; White, Angelicque E.; Karl, David M.; Armbrust, E. Virginia; John, Seth G.
  作者单位：University of Hawaii System; University of Hawaii Manoa; State University System of Florida; University of South Florida; University of Washington; University of Washington Seattle; University of Southern California; University of Alaska System; University of Alaska Fairbanks; Oregon State University; Texas A&M University System; Texas A&M University College Station; Massachusetts Institute of Technology (MIT); Morgan State University; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center
  摘要：Industrial activities have increased the supply of iron to the ocean, but the magnitude of anthropogenic input and its ecological consequences are not well-constrained by observations. Across four expeditions to the North Pacific transition zone, we document a repeated supply of isotopically light iron from an atmospheric source in spring, reflecting an estimated 39 +/- 9 % anthropogenic contribution to the surface ocean iron budget. Expression of iron-stress genes in metatranscriptomes, and e...
• Increased excitatory synapse size in hippocampal place cells compared to silent cells AI翻译
  作者：Heredi, Judit; Olah, Gaspar; Sumegi, Mate; Lukacs, Istvan Paul; Aldahabi, Mohammad; Ujfalussy, Balazs B.; Makara, Judit K.; Nusser, Zoltan
  摘要：Neuronal activity in the hippocampus creates a cognitive map of space that is essential for navigation. In any given environment, a fraction of hippocampal pyramidal cells (PCs) is active at specific locations (place cells), others are sparsely active without spatial tuning, and a significant proportion of the PCs is entirely silent. The mechanisms underlying the vastly different activities of PCs in the rodent hippocampal CA1 area are unknown. Here, we measured the in vivo activity of CA1 PCs...
• Complexity myths and the misappropriation of evolutionary theory AI翻译
  作者：Lynch, Michael
  作者单位：Arizona State University; Arizona State University-Tempe
  摘要：Recent papers by physicists, chemists, and geologists lay claim to the discovery of new principles of evolution that have somehow eluded over a century of work by evolutionary biologists, going so far as to elevate their ideas to the same stature as the fundamental laws of physics. These claims have been made in the apparent absence of any awareness of the theoretical framework of evolutionary biology that has existed for decades. The numerical indices being promoted suffer from numerous conce...
• The analgesic paracetamol metabolite AM404 acts peripherally to directly inhibit sodium channels AI翻译
  作者：Maatuf, Yossef; Kushnir, Yishai; Nemirovski, Alina; Ghantous, Mariana; Iskimov, Ariel; Binshtok, Alexander M.; Priel, Avi
  作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem; Hebrew University of Jerusalem; Hebrew University of Jerusalem
  摘要：Paracetamol has been used for decades to relieve mild-to-moderate pain. Its analgesic effect is mainly attributed to its metabolite, AM404, acting on cannabinoid receptors or TRPV1 channels in central nervous system (CNS) neurons. Here, we show that AM404 is produced by primary sensory neurons. It inhibits sodium current in nociceptor neurons, blocking action potential (AP) generation and reducing nocifensive behavior in na & iuml;ve and inflamed rats. We demonstrated that this analgesic effec...
• Short- term study fails to capture negative impacts of livestock intensification on wildlife AI翻译
  作者：Ogutu, Joseph O.; Stabach, Jared A.; Hopcraft, J. Grant C.; Boone, Randall B.; Dublin, Holly T.; Dutton, Christopher L.; Gichira, Andrew; Guthmann, Abby; Herrik, Ask L.; Holekamp, Kay E.; Karimi, Rebekah R.; Kifugo, Shem C.; Leimgruber, Peter; Mogensen, Niels; Moiko, Stephen S.; Mukeka, Joseph M.; Nabaala, Harrison; Ndambuki, Stephen; Njino, Lucy M.; Ojwang, Gordon O.; Olff, Han; Packer, Craig; Parmuntoro, Lemein; Reid, Robin S.; Rioba, Rehema B.; Said, Mohammed Y.; Senteu, Jully S.; Subalusky, Amanda L.; Svenning, Jens- Christian; Thompson, Stewart; Uzal, Antonio; Veldhuis, Michiel P.; Buitenwerf, Robert
  作者单位：University Hohenheim; Smithsonian Institution; Smithsonian National Zoological Park & Conservation Biology Institute; University of Glasgow; Colorado State University System; Colorado State University Fort Collins; State University System of Florida; University of Florida; University of Minnesota System; University of Minnesota Twin Cities; Aarhus University; Michigan State University; University of Groningen; Colorado State University System; Colorado State University Fort Collins; University of Nairobi; Nottingham Trent University; Leiden University - Excl LUMC; Leiden University
• Macropinosomes are a site of HIV-1 entry into primary CD4+T cells AI翻译
  作者：Murakami, Tomoyuki; Cardoso, Ricardo de Souza; Manivannan, Praveen; Chang, Ya - Ting; Rentchler, Eric; Chou, Kai - Neng; Tang, Yipei; Swanson, Joel A.; King, Philip D.; Ono, Akira
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：HIV-1 has been observed to enter target cells at both the plasma membrane and endosomes. However, which pathways mediate its entry into primary CD4+T cells, the major targets of this virus, remains unclear. Here, we show that HIV-1 can enter primary CD4+ T cells through macropinocytosis, a form of endocytosis. We found that HIV-1 can enter primary CD4+ T cells at both the plasma membrane and internal compartments, while entry into common T cell lines occurred primarily at the plasma membrane. ...
• Disrupted diencephalon development and neuropeptidergic pathways in zebrafish with autism-risk mutations AI翻译
  作者：Capps, Mary E. S.; Moyer, Anna J.; Conklin, Claire L.; Martina, Verdion; Olson, Emma G. Torija -; Klein, Morgan C.; Gannaway, William C.; Calhoun, Caleb C. S.; Vivian, Michael D.; Thyme, Summer B.
  作者单位：University of Alabama System; University of Alabama Birmingham
  摘要：Hundreds of human mutations are linked to autism and related disorders, yet the functions of many of these mutated genes during vertebrate neurodevelopment are unclear. We generated 27 zebrafish mutants with presumptive protein-truncating mutations or specific missense variants corresponding to autism-risk alleles in 17 human genes. We observed baseline and stimulus-driven behavioral changes at larval stages, as well as social behavior differences in lines tested as juveniles. Imaging whole-br...
• Targeting of hyperlipid- producing senescent synovial fibroblasts to ameliorate cartilage degeneration AI翻译
  作者：Hu, Jiajie; Yu, Dongsheng; Wang, Jiasheng; Guo, Peng; Chen, Mingming; Wu, Dongmei; Cai, Youzhi; Wang, Yixuan; Ji, Junfeng; Yao, Xudong; Ouyang, Hongwei
  作者单位：Zhejiang University; Zhejiang University; Liangzhu Laboratory; Zhejiang University; Hangzhou Medical College; Zhejiang Provincial People's Hospital; Zhejiang University; Zhejiang University; Zhejiang University
  摘要：Osteoarthritis (OA) is one of the most common causes of physical disability among older people and its incidence increases with age. Removal of the senescent cells (SNCs) delays OA pathologies, but little is known about the heterogeneity of SNCs and their roles in OA pathogenesis. Here, we identify a subpopulation of senescent synovial cells and proposed a molecular mechanism governing pathogenic synovium-cartilage crosstalk in OA progression. Using single-cell RNA sequencing and synovial orga...
• Endogenous competition and the underrealized reproduction of infectious diseases AI翻译
  作者：Huang, Peng; Almquist, Zack W.; Butts, Carter T.
  作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：Scientific inquiry about the transmissibility of infectious diseases is largely based on the basic reproduction number (R0) and its derivations. This paper describes a mechanism overlooked in most conventional analyses, in which a disease can endogenously compete with itself when multiple infectious individuals race to infect the same susceptible individual, thereby reducing the effective reproductive rate. Utilizing an empirically calibrated network epidemiological model of wild-type COVID-19...