23期

最新文章

• Establishment of cell size-dependent growth rate via differential scaling of metabolite uptake and release AI翻译
  作者：Meliala, Ian; Chen, Jingyuan; Lyu, Jiahang; Bjorklund, Mikael
  作者单位：Zhejiang University; University of Edinburgh
  摘要：Metabolism fuels cell growth and functions. While it is well established that cellular growth rate scales with cell size, how cells alter their metabolism as they change size remains largely unexplored. Here, we conducted a systematic analysis of cell size-dependent metabolism across the NCI60 cancer cell line panel comprising a diverse range of cell sizes. We demonstrate that cellular metabolism and growth rate display 2/3 allometric scaling due to differential scaling of overall nutrient upt...
• Reinforcement generates systematic differences without heterogeneity AI翻译
  作者：Gelastopoulos, Alexandros; Sage, Lucas; van de Rijt, Arnout
  作者单位：University of Southern Denmark; Pompeu Fabra University; Barcelona School of Economics; Universite de Toulouse; European University Institute; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze e Tecnologie della Cognizione (ISTC-CNR)
  摘要：Inequality in outcomes may emerge through a reinforcement process in which stochastic variation in values is determined by prior values but may also originate in preexisting differences in unobserved factors. A common approach toward differentiating between these origins in longitudinal data is to attribute systematic differences between units-differences in means or differences proportional to a time-varying group average-to unobserved heterogeneity. We show that any longitudinal data with sy...
• TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin (112 , 1499-1504, 2015) AI翻译
  作者：Arseni, Lavinia; Lanzafame, Manuela; Compe, Emmanuel; Fortugno, Paola; Afonso-Barroso, Antonio; Peverali, Fiorenzo A.; Lehmann, Alan R.; Zambruno, Giovanna; Egly, Jean-Marc; Stefanini, Miria; Orioli, Donata
• Cochlear zinc signaling dysregulation is associated with noise-induced hearing loss, and zinc chelation enhances cochlear recovery (vol 121, e2310561121, 2024) AI翻译
  作者：Bizup, Brandon; Brutsaert, Sofie; Cunningham, Christopher L.; Thathiah, Amantha; Tzounopoulos, Thanos
• A proteomic signature of healthspan AI翻译
  作者：Kuo, Chia - Ling; Liu, Peiran; Drouard, Gabin; Vuoksimaa, Eero; Kaprio, Jaakko; Ollikainen, Miina; Chen, Zhiduo; Pilling, Luke C.; Atkins, Janice L.; Fortinsky, Richard H.; Kuchel, George A.; Diniz, Breno S.
  作者单位：University of Connecticut; University of Connecticut; University of Connecticut; University of Helsinki; University of Exeter; University of Connecticut
  摘要：The focus of aging research has shifted from increasing lifespan to enhancing healthspan to reduce the time spent living with disability.Despite significant efforts to develop biomarkers of aging, few studies have focused on biomarkers of healthspan. We developed a proteomics-based signature of healthspan [healthspan proteomic score (HPS)] using proteomic data from the Olink Explore 3072 assay in the UK Biobank Pharma Proteomics Project (53,018 individuals and 2,920 proteins). A lower HPS was ...
• Shared disbelief and shared belief: Belief and disbelief as drivers of interpersonal neural synchronization during narrative processing AI翻译
  作者：Braun, Gabriel; Yeshurun, Yaara; Shetreet, Einat
  作者单位：Tel Aviv University; Tel Aviv University; Tel Aviv University
  摘要：Despite living in an era where the mere concept of truth is increasingly contested, the cognitive processes underlying the processing of information we believe or disbelieve remain largely unexplored. In this fMRI study, we investigated how belief modulates narrative processing through belief context-the initial information indicating the speaker's credibility-and actual belief-the truth value ultimately assigned by the listener. Across two experiments, participants listened to narratives prec...
• Sequential drug release system: Targeting the tumor ECM for enhanced chemotherapy efficacy AI翻译
  作者：Cao, Lideng; Li, Zaiye; Song, Dian; Xia, Xin; Zhang, Gaowei; Wang, Hang; Zhao, Hang
  作者单位：Sichuan University; Sichuan University; Chinese Academy of Medical Sciences - Peking Union Medical College; Sichuan University
  摘要：The dense extracellular matrix (ECM) of stroma-rich solid tumors acts as a significant barrier to effective chemotherapy by hindering drug penetration. In this study, a supra-molecular hydrogel was successfully developed, enabling the codelivery and sequential release of hydrophilic and lipophilic drugs designed to target the ECM. The hydrogel is easy to prepare, has self-healing properties and excellent biocompatibility. Upon administration, the hydrogel first releases pirfenidone to inhibit ...
• Deciphering decomposition pathways of high explosives with cryogenic X-ray Raman spectroscopy AI翻译
  作者：Mellone, Oscar A. Paredes; Nielsen, Michael H.; Babicz Jr, Jeffrey Thomas; Vinson, John; Willey, Trevor M.; Sokaras, Dimosthenis
  作者单位：Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; National Institute of Standards & Technology (NIST) - USA
  摘要：We employed cryogenic X-ray Raman spectroscopy to investigate the early-stage decomposition of the high explosive molecule hexanitrohexaazaisowurtzitane (CL-20). By systematically varying the radiation dose under cryogenic conditions, we induced the decomposition of the molecule using ionizing radiation and observed the evolution of spectral features at the carbon, nitrogen, and oxygen K edges. Through extensive first-principles calculations, we identified key intermediates in the early stages...
• Study design and the sampling of deleterious rare variants in biobank-scale datasets AI翻译
  作者：Steiner, Margaret C.; Rice, Daniel P.; Biddanda, Arjun; Ianni-Ravn, Mariadaria K.; Porras, Christian; Novembre, John
  作者单位：University of Chicago; Massachusetts Institute of Technology (MIT); Johns Hopkins University; Icahn School of Medicine at Mount Sinai; University of Chicago
  摘要：One key component of study design in population genetics is the geographic breadth of a sample (i.e., how broad a region across which individuals are sampled). How the geographic breadth of a sample impacts observations of rare, deleterious variants is unclear, even though such variants are of particular interest for biomedical and evolutionary applications. Here, in order to gain insight into the effects of sample design on ascertained genetic variants, we formulate a stochastic model of disp...
• Evolutionarily conserved BON1 regulates the basal cytosolic Ca2+level by calmodulin-independent activation of Ca2+pumps in Arabidopsis AI翻译
  作者：Li, Zhan; Kim, Hyo Jung; Luoni, Laura; Conter, Carolina; Mase, Nicola; Resentini, Francesca; Xie, Peiqiao; Astegno, Alessandra; Bonza, Maria Cristina; Hua, Jian
  作者单位：Cornell University; Xianghu Laboratory; University of Milan; University of Verona
  摘要：Plasma membrane-localized autoinhibited Ca2+ pumps are essential for maintaining basal cytosolic Ca2+ levels for regulating growth processes and environmental responses. These pumps are known to be activated by calmodulins to maintain Ca2+ homeostasis in plants and animals. Here, we demonstrate that the evolutionarily conserved copine protein BON1 is critical for maintaining low cytosolic Ca2+ concentrations by directly regulating two plasma membrane-localized Ca2+ pumps ACA8 and ACA10 inArabi...