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作者：Gonzalez-Magaldi, Monica; Gullapalli, Anuradha; Papoulas, Ophelia; Liu, Chang; Leung, Adelaide Y. -H.; Guo, Luqiang; Brilot, Axel F.; Marcotte, Edward M.; Ke, Zunlong; Leahy, Daniel J.
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：We report here transport of full-length epidermal growth factor receptor (EGFR), Insulin Receptor, 7-pass transmembrane receptor Smoothened, and 13-pass Sodium-iodide symporter to extracellular vesicles (EVs) for structural and functional studies. Mass spectrometry confirmed the transported proteins are the most abundant in EV membranes, and the presence of many receptor-interacting proteins in EVs demonstrates their utility for characterizing membrane protein interactomes. Cryo-electron tomog...
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作者：Guo, Jiani; Liu, Mengyao; Liu, Feng; Wang, Lu
作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Hematology & Blood Diseases Hospital - CAMS; Peking Union Medical College; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Institute of Zoology, CAS
摘要：The tightly controlled spatiotemporal expression of developmental genes depends on the concerted action of cis-regulatory elements (CREs) and transcription factors (TFs) to ensure cell fate decisions. Endothelial-to-hematopoietic transition (EHT) is a cell fate transition process by which endothelial cells acquire hematopoietic identity and become hemogenic endothelial cells (HECs) and then hematopoietic stem and progenitor cells, but the underlying CRE network dynamics and its regulation by T...
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作者：Van der Meersch, Victor; Wolkovich, E. M.
作者单位：University of British Columbia; Universite Paul-Valery; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite PSL; Institut Agro; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro Montpellier
摘要：Multiple studies have recently proposed the summer solstice as a universal cue for major plant physiological processes. While this would have strong implications for fundamental plant biology and climate change forecasting, we currently have no clear mechanisms to explain the emergence and importance of solstice as a cue. Here, we analyze temperature accumulation patterns in relation to the summer solstice across Europe and North America-in past, historical, and projected future climates. We s...
