23期

最新文章

• Parallel sensory compensation following independent subterranean colonization by groundwater salamanders (Eurycea) AI翻译
  作者：Tovar, Ruben U.; Dobbins, Brittany A.; Hartman, Nicholas R.; Leelani, Sheena; Devitt, Thomas J.; Garcia, Dana M.; Gignac, Paul M.; Cannatella, David C.; Hillis, David M.
  作者单位：University of Texas System; University of Texas Austin; Texas State University System; Texas State University San Marcos; University of Arizona
  摘要：Lineages that have invaded subterranean environments have repeatedly evolved remarkable adaptations to life in darkness. However, observational and experimental studies in additional natural systems are needed to further our understanding of repeated evolution and convergence. In Texas, a radiation of groundwater salamanders (genus Eurycea), with independent invasions of subterranean karstic environments, offers an opportunity to investigate phenotypic convergence, parallel evolution, and the ...
• Reply to Ogutu et al.: Cattle-wild herbivore interaction studies warrant new lenses from community ecology and environmental justice AI翻译
  作者：Butt, Bilal; Xu, Wenjing
  作者单位：University of Michigan System; University of Michigan; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Senckenberg Biodiversitat & Klima- Forschungszentrum (BiK-F)
• Sensitivity of simulations of Plio-Pleistocene climate with the CLIMBER-2 Earth System Model to details of the global carbon cycle AI翻译
  作者：Carrillo, Judit; Mann, Michael E.; Marinov, Irina; Christiansen, Shannon A.; Willeit, Matteo; Ganopolski, Andrey
  作者单位：University of Pennsylvania; Universidad de la Laguna; Potsdam Institut fur Klimafolgenforschung
  摘要：The Earth system model CLIMBER-2 has been used in past work to successfully reproduce the glacial/interglacial cycles of the Plio-Pleistocene and the Mid-Pleistocene Transition (MPT) from predominantly 40 to 100 ky timescale oscillatory behavior as a function of declining volcanic outgassing and regolith removal. In this study, we further examine the sensitivity of this previous work to varying prescribed levels of volcanic outgassing and regolith extent and the long-term dynamics of the globa...
• Multiple cortical systems influence a single vibrissa muscle AI翻译
  作者：Maharjan, Aman; Guest, Jason M.; Rathelot, Jean- Alban; Osorio, Fiorella M. Gomez; Strick, Peter L.; Oberlaender, Marcel
  作者单位：Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Vrije Universiteit Amsterdam; Max Planck Society; Heinrich Heine University Dusseldorf
  摘要：What is the neural substrate that enables the cerebral cortex to control a single mystacial vibrissa and orchestrate its movement? To answer this question, we injected rabies virus into the intrinsic muscle that protracts the rat C3 vibrissa and used retrograde transneuronal transport to identify the cortical neurons that influence the muscle. A surprisingly diverse set of cortical areas is the origin of disynaptic control over the motoneurons that influence the C3 protractor. More than two th...
• The highly conserved intron of tyrosine tRNA is critical for m1A58 modification and controls the integrated stress response AI翻译
  作者：Stuart, Catherine J.; Hurtig, Jennifer E.; Tzadikario, Talia; Thomas, Niki K.; Jain, Miten; van Hoof, Ambro
  作者单位：University of Texas System; University of Texas Health Science Center Houston; Northeastern University
  摘要：tRNA introns are a universally conserved feature of eukaryotic genomes, but the reason for their conservation has remained obscure. We have previously shown that a defect in the essential tRNA splicing endonuclease of yeast results in transcriptome remodeling, resembling that of the integrated stress response (ISR). In this study, we show that ISR activation in this mutant requires the canonical ISR components, including the collided ribosome sensor Gcn1. We further show that splicing of tyros...
• High- throughput metabolic engineering of Yarrowia lipolytica through gene expression tuning AI翻译
  作者：Jiang, Wei; Wang, Shengbao; Ahlheit, Daniel; Fumagalli, Tommaso; Yang, Zhijie; Ramanathan, Shreemaya; Jiang, Xinglin; Weber, Tilmann; Dahlin, Jonathan; Borodina, Irina
  作者单位：Technical University of Denmark; Aalborg University; University of Milano-Bicocca
  摘要：The challenge of accurately predicting which genetic alternations lead to the desired phenotype necessitates high-throughput metabolic engineering approaches where numerous hypotheses can be tested simultaneously. We describe the CRISPR-Cas9-based method TUNEYALI that enables high-throughput tuning of gene expression in the common industrial yeast Yarrowia lipolytica. The method is based on replacing the promoters of the target genes with native Y. lipolytica promoters of varying strengths or ...
• Convergent expansions of keystone gene families drive metabolic innovation in Saccharomycotina yeasts AI翻译
  作者：David, Kyle T.; Schraiber, Joshua G.; Crandall, Johnathan G.; Labella, Abigail L.; Opulente, Dana A.; Harrison, Marie- Claire; Wolters, John F.; Zhou, Xiaofan; Shen, Xing - Xing; Groenewald, Marizeth; Hittinger, Chris Todd; Pennell, Matt; Rokas, Antonis
  作者单位：Vanderbilt University; Vanderbilt University; University of Southern California; University of Southern California; University of Wisconsin System; University of Wisconsin Madison; University of North Carolina; University of North Carolina Charlotte; Villanova University; Guangdong Laboratory for Lingnan Modern Agriculture; South China Agricultural University; Cornell University
  摘要：Many remarkable phenotypes have repeatedly occurred across vast evolutionary distances. When convergent traits emerge on the tree of life, they are sometimes driven by the same underlying gene families, while other times, many different gene families are involved. Conversely, a gene family may be repeatedly recruited for a single trait or many different traits. To understand the general rules governing convergence at both genomic and phenotypic levels, we systematically tested associations bet...
• Updated fossil analyses reveal critical insights into the origins of monotreme lifestyles AI翻译
  作者：Whitney, Megan R.
  作者单位：Loyola University Chicago
• Jund orchestrates cis- regulatory element dynamics to facilitate endothelial- to- hematopoietic transition AI翻译
  作者：Guo, Jiani; Liu, Mengyao; Liu, Feng; Wang, Lu
  作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Hematology & Blood Diseases Hospital - CAMS; Peking Union Medical College; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Institute of Zoology, CAS
  摘要：The tightly controlled spatiotemporal expression of developmental genes depends on the concerted action of cis-regulatory elements (CREs) and transcription factors (TFs) to ensure cell fate decisions. Endothelial-to-hematopoietic transition (EHT) is a cell fate transition process by which endothelial cells acquire hematopoietic identity and become hemogenic endothelial cells (HECs) and then hematopoietic stem and progenitor cells, but the underlying CRE network dynamics and its regulation by T...
• Summer solstice optimizes the thermal growing season AI翻译
  作者：Van der Meersch, Victor; Wolkovich, E. M.
  作者单位：University of British Columbia; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro; Montpellier SupAgro; CIRAD; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paul-Valery; Universite de Montpellier
  摘要：Multiple studies have recently proposed the summer solstice as a universal cue for major plant physiological processes. While this would have strong implications for fundamental plant biology and climate change forecasting, we currently have no clear mechanisms to explain the emergence and importance of solstice as a cue. Here, we analyze temperature accumulation patterns in relation to the summer solstice across Europe and North America-in past, historical, and projected future climates. We s...