23期

最新文章

• Climate warming increases global oceanic dimethyl sulfide emissions AI翻译
  作者：Joge, Sankirna D.; Mansour, Karam; Simo, Rafel; Gali, Marti; Steiner, Nadja; Lopez, Alfonso Saiz-; Mahajan, Anoop S.
  作者单位：Ministry of Earth Sciences (MoES) - India; Indian Institute of Tropical Meteorology (IITM); Savitribai Phule Pune University; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze dell'Atmosfera e del Clima (ISAC-CNR); Egyptian Knowledge Bank (EKB); Alexandria University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Mediterraneo de Investigaciones Marinas y Ambientales (CMIMA); CSIC - Instituto de Ciencias del Mar (ICM); Fisheries & Oceans Canada; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC)
  摘要：Oceanic dimethyl sulfide (DMS) is the largest natural source of atmospheric sulfur. DMS is biologically produced in seawater and emitted into the atmosphere, where its oxidation products contribute to aerosol formation with consequences for cloud albedo and the Earth's radiative budget and climate. Climate model projections of how DMS emissions change with global warming are largely uncertain, even contradictory. Here, we use machine- learning models trained with biome- resolved global observa...
• Declining coral calcification to enhance twenty- first- century ocean carbon uptake by gigatonnes AI翻译
  作者：Kwiatkowski, Lester; Planchat, Alban; Pyolle, Marc; Torres, Olivier; Bouttes, Nathaelle; Courte, Adrien; Bopp, Laurent
  作者单位：University of Bern; University of Bern; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Sorbonne Universite; Universite Paris Saclay; Institut de Recherche pour le Developpement (IRD); Museum National d'Histoire Naturelle (MNHN); Institut Polytechnique de Paris; Ecole Polytechnique; Universite PSL; Ecole Normale Superieure (ENS); Sorbonne Universite; Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); Ifremer; Institut de Recherche pour le Developpement (IRD); Universite de Bretagne Occidentale
  摘要：The sensitivity of coral reefs to climate change is well established. As the oceans warm and acidify, the calcification of coral reefs declines with net calcium carbonate dissolution projected under even moderate emissions trajectories. The impact of this on the global carbon cycle is however yet to be accounted for. Here, we use a synthesis of the sensitivity of coral reef calcification to climate change, alongside reef distribution products to estimate alkalinity and dissolved inorganic carb...
• Reciprocal projections between the globus pallidus externa and cortex span motor and nonmotor regions AI翻译
  作者：Ferenczi, Emily A.; Wang, Wengang; Biswas, Anushka; Pottala, Trent; Dong, Yihuan; Chan, Alison K.; Albanese, Madeline A.; Sohur, Raina S.; Jia, Tingying; Mastro, Kevin J.; Sabatini, Bernardo L.
  作者单位：Howard Hughes Medical Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Princeton University
  摘要：The globus pallidus externa (GPe) is a heterogeneous nucleus of the basal ganglia, with intricate connections to other basal ganglia nuclei, as well as direct connections to the cortex. The anatomic, molecular, and electrophysiologic properties of cortex-projecting pallidocortical neurons are not well characterized. Here, we show that pallidocortical neurons project to diverse motor and nonmotor cortical regions, are organized topographically in the GPe, and segregate into at least two distinc...
• Material properties of biomolecular condensates emerge from nanoscale dynamics AI翻译
  作者：Galvanetto, Nicola; Ivanovic, Milos T.; Grosso, Simone A. Del; Chowdhury, Aritra; Sottini, Andrea; Nettels, Daniel; Best, Robert B.; Schuler, Benjamin
  作者单位：University of Zurich; University of Zurich; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
  摘要：Biomolecular condensates form by phase separation of biological polymers and have important functions in the cell-functions that are inherently linked to their physical properties at different scales. A notable aspect of such membraneless organelles is that their viscoelastic properties can vary by orders of magnitude, but it has remained unclear how these pronounced differences are rooted in the nanoscale dynamics at the molecular level. Here, we investigate a series of condensates formed by ...
• Water- rich incipient melt of the deep upper mantle indicates locally preserved low- velocity zones above the 410 km discontinuity AI翻译
  作者：Xie, Longjian; Katsura, Tomoo; Miyajima, Nobuyoshi; Qu, Tongzhang; Mao, Ho-Kwang
  作者单位：University of Bayreuth; University of London; University College London
  摘要：Seismic low-velocity layers (LVLs), frequently attributed to hydrous-silicate melts, are detected globally but exhibit lateral discontinuities. Geophysical and laboratory studies of water content in the mantle transition zone (MTZ) and upper mantle solubility limits suggest these layers likely form through global dehydration melting near the 410 km discontinuity (D410). A key hypothesis posits that melts form globally but are preserved only where melt stability permits retention. However, chal...
• The tumor suppressor RASSF8: A WAVE interaction partner controlling migration and cohesion of invasive border cells in Drosophila AI翻译
  作者：Hoehne, Mila Y.; Milani, Wiebke; Ramlow, Kirsten; Bogdan, Sven
  作者单位：Philipps University Marburg
  摘要：Collective cell migration is a key driver of tissue morphogenesis and cancer invasion. Here, we identified the tumor suppressor Ras association domain-containing protein 8 (RASSF8) as a WAVE interactor required for border cell migration. RASSF8 colocalizes with F-actin and cell adhesion molecules at border cell-border cell contacts. Loss of RASSF8 function results in border cell cohesion defects, a phenotype associated with changes in the localization of the Echinoid (Ed) and Coracle (Cora). C...
• Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling (vol 113, pg E3773, 2016) AI翻译
  作者：Yin, Yaling; Gao, Di; Wang, Yali; Wang, Zhi-Hao; Wang, Xin; Ye, Jinwang; Wu, Dongqin; Fang, Lin; Pi, Guilin; Yang, Ying; Wang, Xiao-Chuan; Lu, Chengbiao; Ye, Keqiang; Wang, Jian-Zhi
• Early dynamics of chromatin decompaction drive nuclear stiffening AI翻译
  作者：Ivanovska, Irena L.
  作者单位：University of Pennsylvania
• Suborbital- and millennial- scale monsoon variability during Pleistocene interglacials AI翻译
  作者：Sun, Youbin; Wang, Ting; Yin, Qiuzhen; Clemens, Steven C.; Liu, Xingxing; Ai, Li; Wu, Zhipeng; Qiang, Xiaoke; Wang, Xulong; Chang, Hong; Song, Yougui; Vogel, Hendrik; Dodson, John; Berger, Andre; An, Zhisheng
  作者单位：Chinese Academy of Sciences; Institute of Earth Environment, CAS; Hubei Engineering University; Universite Catholique Louvain; Brown University; University of Bern; University of Bern; University of New South Wales Sydney; Laoshan Laboratory
  摘要：Observational and modeling results show that the frequency and amplitude of extreme climatic events have increased significantly in the context of global warming. However, whether abrupt climate changes intensified during past warm periods remains poorly constrained due to the lack of high- resolution geological records. Here, we report a 512- m predominantly lacustrine sedimentary record from the Weihe Basin (North China), revealing that lake levels fluctuated significantly on suborbital (hal...
• Direct sensing of host ferric iron by an archetype histidine kinase mediates virulence of an enteric pathogen AI翻译
  作者：Zhang, Yibei; Xiao, Gang; Ding, Haoyuan; Zou, Qian; Gu, Dan; Wen, Jiachen; Pei, Yonggang; Guo, Rongxian; Wang, Qiyao; Zhou, Xiaohui
  作者单位：Southern University of Science & Technology; East China University of Science & Technology; Yangzhou University; Shenyang Pharmaceutical University; Henan University of Science & Technology
  摘要：Two-component system (TCS) histidine kinases enable bacterial pathogens to sense environmental signals and regulate adaptive responses during infection. The EnvZ/ OmpR TCS, known for its role in osmolarity/pH-dependent regulation of outer membrane porins across bacterial species, is also a central virulence regulator. However, the environmental cues that activate EnvZ/OmpR to trigger pathogenicity have remained unclear, limiting our understanding of host-pathogen interactions. Here, we demonst...