23期

最新文章

• In- plane ferroelectricity with high Curie temperatures in nonequilibrium SnSe1-xSx van der Waals semiconductors AI翻译
  作者：Sutter, Eli; Sutter, Peter
  作者单位：University of Nebraska System; University of Nebraska Lincoln; University of Nebraska System; University of Nebraska Lincoln
  摘要：While symmetry breaking in 2D ferroelectrics is obviously linked to the single- layer structure, layered (van der Waals) ferroelectrics can have a multitude of underlying mechanisms, making their identification nontrivial and often controversial. This complexity is exemplified by tin chalcogenides whose equilibrium structure, the orthorhombic ox- phase with space group Pnma, includes an inversion center and which therefore should not be ferroelectric. Yet, recent work demonstrated polarization...
• Transcranial direct current stimulation neuromodulates intracranial cognitive evoked activity in humans AI翻译
  作者：Tabikh, Mireille; Quetu, Tom; Maillard, Louis; Coulbois, Sophie Colnat -; Rossion, Bruno; Koessler, Laurent
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Universite de Lorraine; Universite de Lorraine; CHU de Nancy; CHU de Nancy; Universite de Lorraine
  摘要：Transcranial direct current stimulation (tDCS) is an easy to use, noninvasive brain stimulation technique that gained prominence for its potential in cognitive rehabilitation. Electroencephalography (EEG), which records electrical brain activity with a high temporal resolution, is well suited to quantify tDCS- induced neuromodulation in humans. However, most studies relying on scalp EEG recordings or event- related potentials showed low reliability and only indirect correlations. Here, we comb...
• Pathophysiologically relevant bisphenol S exposure accelerates aging by disrupting brown adipose tissue-regulated energy metabolism AI翻译
  作者：Zhu, Man; Wang, Ru; Yi, Wei; Wu, Beiyi; Deng, Zhizhong; Zhang, Zheng; Wang, Chen; Zhang, Dingkun; Zhang, Tongtong; Wen, Xue
  作者单位：Sichuan University; University of Electronic Science & Technology of China; Sichuan University; Southwest Jiaotong University; Soochow University - China; Sichuan University; Southwest Jiaotong University
  摘要：Bisphenol A (BPA) substitutes are widely used as food contact materials and consumer products, while the effects of pathophysiologically relevant concentrations of BPA substitutes on aging remain unclear. In this study, we used Caenorhabditis elegans (C. elegans) to investigate the effects of five BPA substitutes [bisphenol S (BPS), bisphenol B, bisphenol F (BPF), tetramethyl BPF, and 4,4 '-(Perfluoropropane-2,2-diyl)diphenol] at pathophysiologically relevant exposure levels during aging and e...
• Assembly and activation of the death-inducing signaling complex AI翻译
  作者：Fosuah, Elizabeth; Shen, Zhangfei; Xie, Jiale; Wang, Chen; Lin, Qingpeng; Fu, Tian-Min
  作者单位：University System of Ohio; Ohio State University; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
  摘要：The death-inducing signaling complex (DISC), comprising Fas, Fas-associated death domain (FADD), and caspase-8, initiates extrinsic apoptosis. Using cryogenic electron microscopy (cryo-EM), we show that Fas and FADD death domains (DDs) form an asymmetric 7:5 oligomer, which promotes FADD death effector domain (DED) filament formation. Structural analysis reveals that FADD DED filaments closely resemble caspase-8 tandem DED filaments, suggesting that FADD DED serves as a nucleation scaffold for...
• Light at night negatively affects mood in diurnal primate- like tree shrews via a visual pathway related to the perihabenular nucleus AI翻译
  作者：Miao, Ying; Zhao, Huan; Li, Yu-Fei; Sun, Yan-Ping; Bi, Rui; Li, Hongli; Fang, Xin; Li, Zi-Shuo; Ma, Yu-Hua; Lv, Long-Bao; An, Kai; Meng, Jian-Jun; Yao, Yong-Gang; Xue, Tian
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Hefei University; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：To better understand the potential health threats and underlying visual pathways of long-term light at night (LAN) exposure, we adopted a widely accepted diurnal animal model tree shrew (Tupaia belangeri chinensis), which is a close relative to primates, and evaluated the deleterious effects of long-term LAN exposure. We used an early-night LAN paradigm that was established in mice to examine behavioral and physiological consequences in adult male tree shrews. We found that 3-wk LAN exposure s...
• Dynamic relocation of PKA regulatory subunits during sperm capacitation: Linking PKA to the CatSper signaling complex AI翻译
  作者：Novero, Analia G.; Volante, Arturo Matamoros -; Gomez -Olivieri, Lucila R.; Stival, Cintia; Luque, Guillermina M.; Szalai, Alan M.; Ambrosio, Andrea L.; Stefani, Fernando D.; Buffone, Mariano G.; Krapf, Dario; Krapf, Diego
  作者单位：National University of Rosario; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of Rosario; Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Colorado State University System; Colorado State University Fort Collins; University of Buenos Aires
  摘要：To fertilize an oocyte, mammalian spermatozoa must undergo a maturation step known as capacitation that takes place after ejaculation. Protein kinase A (PKA) plays a fundamental role in capacitation in all mammalian species. Before capacitation, PKA is maintained in an inactive state where the catalytic subunits are bound to a dimer of inhibitory regulatory subunits. A key element in the regulation of PKA lies in its intracellular compartmentalization achieved by docking at A-kinase anchoring ...
• The cell-permeable iron chelator M606 inhibits MYCN-driven neuroblastoma via an E2F3-mediated response AI翻译
  作者：Pandher, Ruby; Xue, Chengyuan; Gamble, Laura D.; Milazzo, Giorgio; Di Giacomo, Simone; Murray, Jayne; Cheung, Leanna; Ferrucci, Francesca; Palombo, Marta; Purgato, Stefania; Burkhart, Catherine A.; Fedtsova, Natalia; Gleiberman, Anatoli S.; Purmal, Andrei A.; Korotchkina, Lioubov; Nikiforov, Mikhail A.; Makarov, Sergei S.; Telfer, Thomas J.; Codd, Rachel; Marshall, Glenn M.; Scott, David A.; Osterman, Andrei L.; Gudkov, Andrei, V; Perini, Giovanni; Haber, Michelle; Norris, Murray D.
  作者单位：Children's Cancer Institute; University of New South Wales Sydney; University of Bologna; Roswell Park Comprehensive Cancer Center; University of Sydney; NSW Health; Sydney Childrens Hospitals Network; University of Sydney; Sanford Burnham Prebys Medical Discovery Institute; University of New South Wales Sydney
  摘要：Despite Myc oncoproteins being major causal factors in human cancer, they remain undruggable. The MYCN oncogene is one of the most powerful prognostic markers for the childhood cancer neuroblastoma and represents an important target for developing novel therapeutics. Here, we report the finding and characterization of M606, a selective small molecule inhibitor of MYCN, which was identified by screening a diverse chemical library. M606 reduced MYCN protein levels in neuroblastoma cell lines and...
• Controlling DNA-RNA strand displacement kinetics with base distribution AI翻译
  作者：Ratajczyk, Eryk J.; Bath, Jonathan; Sulc, Petr; Doye, Jonathan P. K.; Louis, Ard A.; Turberfield, Andrew J.
  作者单位：University of Oxford; University of Oxford; University of Oxford; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Technical University of Munich; University of Oxford
  摘要：DNA-RNA hybrid strand displacement underpins the function of many natural and engineered systems. Understanding and controlling factors affecting DNA-RNA strand displacement reactions is necessary to enable control of processes such as CRISPR-Cas9 gene editing. By combining multiscale modeling with strand displacement experiments, we show that the distribution of bases within the displacement domain has a very strong effect on reaction kinetics, a feature unique to DNA-RNA hybrid strand displa...
• Programmable seconds- to- days- long delayed snapping in jumping metashells AI翻译
  作者：Qing, Haitao; Zhou, Caizhi; Qi, Fangjie; Yin, Jie
  作者单位：North Carolina State University
  摘要：Shape- shifting structures can transform and recover their shapes in response to external stimuli, but they often lack programmable, clock- like control over spatiotemporal deformation and motion, especially after stimuli are removed. Achieving autonomous, time- regulated spatiotemporal motion remains a grand challenge. Here, we present an autonomous delayed- jumping metashell that integrates viscoelastic materials with monostable architected structures to address this limitation. The metashel...
• Increasing boreal fires reduce future global warming and sea ice loss AI翻译
  作者：Blanchard-Wrigglesworth, Edward; Derepentigny, Patricia; Frierson, Dargan M. W.
  作者单位：University of Washington; University of Washington Seattle
  摘要：Biomass burning can affect climate via the emission of aerosols and their subsequent impact on radiation, cloud microphysics, and surface and atmospheric albedo. Biomass burning emissions (BBEs) over the boreal region have strongly increased during the last decade and are expected to continue increasing as the climate warms. Climate models simulate aerosol processes, yet historical and future Coupled Model Intercomparison Project (CMIP) simulations have no active fire component, and BBEs are p...