23期

最新文章

• BRCA2 reversion mutation-independent resistance to PARP inhibition through impaired DNA prereplication complex function AI翻译
  作者：Pappas, Kyrie; Ferrari, Matteo; Smith, Perianne; Nandakumar, Subhiksha; Khan, Zahra; Young, Serina B.; Laclair, Justin; Russo, Marco Vincenzo; Hobbs, Emmet Huang; Schultz, Nikolaus; Abida, Wassim; Karthaus, Wouter; Jasin, Maria; Sawyers, Charles L.
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; University of Minnesota System; University of Minnesota Twin Cities; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Columbia University; NewYork-Presbyterian Hospital; Albany Medical College; University of Miami; Memorial Sloan Kettering Cancer Center; Swiss Institute Experimental Cancer Research; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Howard Hughes Medical Institute
  摘要：Recent approvals of polymeric adenosine diphosphate ribose (poly(ADP-ribose) polymerase inhibitors (PARPi) for BRCA-mutant metastatic castration resistant prostate cancer necessitate an understanding of the factors that shape sensitivity and resistance. Reversion mutations that restore homologous recombination (HR) repair are detected in similar to 50 to 80% of BRCA-mutant patients who respond but subsequently relapse, but there is currently little insight into why only similar to 50% of BRCA-...
• Broadband measurement of Feibelman's quantum surface response functions AI翻译
  作者：Chen, Zeling; Yang, Shu; Xie, Zetao; Hu, Jinbing; Zhang, Xudong; Xia, Yipu; Shen, Yonggen; Su, Huirong; Xie, Maohai; Christensen, Thomas; Yang, Yi
  作者单位：University of Hong Kong; University of Hong Kong; University of Shanghai for Science & Technology; Technical University of Denmark
  摘要：Feibelman d-parameter, a mesoscopic complement to the local bulk permittivity, describes quantum optical surface responses for interfaces, including nonlocality, spill-in and-out, and surface-enabled Landau damping. It has been incorporated into the macroscopic Maxwellian framework for convenient modeling and understanding of nanoscale electromagnetic phenomena, calling for the compilation of d-parameter database for interfaces of interest in nano-optics. However, accurate first principles cal...
• A green dichromophoric protein enabling foliage mimicry in arthropods AI翻译
  作者：Egorkin, Nikita A.; Aleksin, Anatoly M.; Sedlov, Ilya A.; Zhiganov, Nikita I.; Bodunova, Daria V.; Varfolomeeva, Larisa A.; Slonimskiy, Yury B.; Ziganshin, Rustam H.; Popov, Vladimir O.; Boyko, Konstantin M.; Vassilevski, Alexander A.; Maksimov, Eugene G.; Sluchanko, Nikolai N.
  作者单位：Research Center of Biotechnology RAS; Russian Academy of Sciences; Lomonosov Moscow State University; Lomonosov Moscow State University; Lomonosov Moscow State University; Lomonosov Moscow State University; Research Center of Biotechnology RAS; Russian Academy of Sciences; Russian Academy of Sciences; Pushchino Scientific Center for Biological Research (PSCBI) of the Russian Academy of Sciences; Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Russian Academy of Sciences; Pushchino Scientific Center for Biological Research (PSCBI) of the Russian Academy of Sciences; Institute of Bioorganic Chemistry of the Russian Academy of Sciences
  摘要：Molecular mechanisms underlying the green insect camouflage have puzzled researchers for over a century. Here, we isolated and identified a green water-soluble protein from the integument of bush-cricket Tettigonia cantans. De novo sequencing and cloning revealed a severely fragmented form of vitellogenins, ubiquitous and multifunctional, but still largely enigmatic glycolipoproteins essential for embryonic development and lacking structural characterization. The distinctive color of the ident...
• A skin-interfaced wireless wearable device and data analytics approach for sleep-stage and disorder detection AI翻译
  作者：Du, Yayun; Gu, Jianyu; Duan, Shiyuan; Trueb, Jacob; Tzavelis, Andreas; Shin, Hee-Sup; Arafa, Hany; Li, Xiuyuan; Huang, Yonggang; Carr, Andrew N.; Davies, Charles R.; Rogers, John A.
  作者单位：Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine; Northwestern University; Procter & Gamble; Northwestern University; Northwestern University; Northwestern University
  摘要：Accurate identification of sleep stages and disorders is crucial for maintaining health, preventing chronic conditions, and improving diagnosis and treatment. Direct respiratory measurements, as key biomarkers, are missing in traditional wrist-or finger-worn wearables, which thus limit their precision in detection of sleep stages and sleep disorders. By contrast, this work introduces a simple, multimodal, skin-integrated, energy-efficient mechanoacoustic sensor capable of synchronized cardiac ...
• Natural dispersal is better than translocation for reducing risks of inbreeding depression in eastern black rhinoceros (Diceros bicornis michaeli) AI翻译
  作者：Mellya, Ronald. V. K.; Hopcraft, J. Grant C.; Mwakilema, William; Eblate, Ernest M.; Mduma, Simon; Mnaya, Bakari; Chuma, Idrissa S.; Macha, Emmanuel S.; Wambura, Dickson; Fyumagwa, Robert D.; Kilbride, Elizabeth; Ijaz, Umer Z.; Mable, Barbara K.; Khan, Anubhab
  作者单位：University of Glasgow; University of Glasgow; Indian Institute of Science (IISC) - Bangalore
  摘要：Due to increasing anthropogenic impacts, many species survive only in small and isolated populations. Active conservation management to reduce extinction risk includes increasing habitat connectivity, translocations from captive populations, or intensive surveillance of highly protected closed populations. Advances in sequencing technology mean that it is now possible to consider the genomic impacts of such strategies, as a proxy for variation in individual fitness. Using whole genome sequence...
• Creb5 controls its own expression and directly induces the joint interzone regulatory program AI翻译
  作者：Zhang, Cheng- Hai; Shahini, Aref; Cook, Laura E.; Mistry, Meeta; Kim, Jongkil; Wick, Heather; Pennacchio, Len A.; Lassar, Andrew B.
  作者单位：Harvard University; Harvard Medical School; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：Prior studies have indicated that the transcription factor Creb5 is expressed in the joint interzone, which contains the progenitors for all synovial joint tissues in both mouse and human embryos. In the absence of Creb5 function, most synovial joint interzones fail to form and the cartilage templates in the long bones remain fused. This earlier work did not clarify whether Creb5 initiates a cascade of signaling molecules, such as growth and differentiation factor 5 (Gdf5) and Wnt- family memb...
• Circuit complexity and functionality: A statistical thermodynamics perspective AI翻译
  作者：Chamon, Claudio; Ruckenstein, Andrei E.; Mucciolo, Eduardo R.; Canetti, Ran; Coppersmith, Susan
  作者单位：Boston University; State University System of Florida; University of Central Florida; Boston University
  摘要：Circuit complexity, defined as the minimum circuit size required for implementing a particular Boolean computation, is a foundational concept in computer science. Determining circuit complexity is believed to be a hard computational problem. Recently, in the context of black holes, circuit complexity has been promoted to a physical property, wherein the growth of complexity is reflected in the time evolution of the Einstein-Rosen bridge (wormhole) connecting the two sides of an anti-de Sitter ...
• Physics of notochord tube expansion in ascidians AI翻译
  作者：Shi, Wenjie; Duclut, Charlie; Xu, Yan; Ma, Yuanting; Qiao, Jinghan; Lin, Boyan; Yang, Dongyu; Prost, Jacques; Dong, Bo
  作者单位：Ocean University of China; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite PSL; UNICANCER; Institut Curie; Sorbonne Universite; National University of Singapore; Ocean University of China
  摘要：Interaction of cells and the surrounding lumen drives the formation of tubular system that plays the transport and exchange functions within an organism. The physical and biological mechanisms of lumen expansion have been explored. However, how cells communicate and coordinate with the surrounding lumen, leading to continuous tube expansion to a defined geometry, is crucial but remains elusive. In this study, we utilized the ascidian notochord tube as a model to address the underlying mechanis...
• Targeting amyloid-β in glaucoma treatment (vol 104, pg 13444, 2007) AI翻译
  作者：Guo, Li; Salt, Thomas E.; Luong, Vy; Wood, Nicholas; Cheung, William; Maass, Annelie; Ferrari, Giulio; Russo-Marie, Feancoise; Sillito, Adam M.; Cheetham, Michael E.; Moss, Stephen E.; Fitzke, Frederick W.; Cordeiro, M. Francesca
• Structure and organization of full-length epidermal growth factor receptor in extracellular vesicles by cryo-electron tomography AI翻译
  作者：Gonzalez-Magaldi, Monica; Gullapalli, Anuradha; Papoulas, Ophelia; Liu, Chang; Leung, Adelaide Y. -H.; Guo, Luqiang; Brilot, Axel F.; Marcotte, Edward M.; Ke, Zunlong; Leahy, Daniel J.
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
  摘要：We report here transport of full-length epidermal growth factor receptor (EGFR), Insulin Receptor, 7-pass transmembrane receptor Smoothened, and 13-pass Sodium-iodide symporter to extracellular vesicles (EVs) for structural and functional studies. Mass spectrometry confirmed the transported proteins are the most abundant in EV membranes, and the presence of many receptor-interacting proteins in EVs demonstrates their utility for characterizing membrane protein interactomes. Cryo-electron tomog...