23期

最新文章

• Stepwise deactivation of gibberellins during rice internode elongation AI翻译
  作者：Ishida, Toshiaki; Zhang, Yingying; Zhu, Hongbo; Fudano, Shoko; Peng, Yu; Seto, Yoshiya; Mashiguchi, Kiyoshi; Liu, Jiyun; He, Zuhua; Zhang, Shubiao; Yamaguchi, Shinjiro
  作者单位：Kyoto University; Tohoku University; Shanghai Academy of Agricultural Sciences; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Fujian Agriculture & Forestry University; Guangdong Ocean University; Meiji University
  摘要：Bioactive gibberellins (GAs) are a class of plant hormones that regulate various aspects of plant growth and development, and several key GA deactivation enzymes have been identified. In rice, non- 13- hydroxylated GAs have been shown to be deactivated via 160x,17- epoxidation by a cytochrome P450 monooxygenase, ELONGATED UPPERMOST INTERNODE the product of EUI from bioactive GA4, has shown weak bioactivity on rice seedlings, how 160x,17- epoxyGAs are further deactivated remains elusive. Here, ...
• Revealing land control dynamics in emerging agricultural frontiers AI翻译
  作者：del Giorgio, Olivia; Baumann, Matthias; Kuemmerle, Tobias; de Waroux, Yann le Polain
  作者单位：McGill University; Humboldt University of Berlin; Humboldt University of Berlin; McGill University
  摘要：The expansion of commodity agriculture into tropical and subtropical woodlands degrades ecosystem functionality, biodiversity, and the livelihood base of millions of people. Understanding where and how agricultural frontiers emerge is thus important. Yet, existing monitoring approaches typically focus on mapping deforestation and do not capture the shifts in land access and ownership that lay the ground for agricultural expansion, thereby missing early stages of frontier development. We develo...
• Reply to Apanovich and Weeks: Exceptions exist, as recognized in the paper, but are too rare to challenge the original findings AI翻译
  作者：Eshel, Gidon; Flamholz, Avi I.; Shepon, Alon; Milo, Ron
  作者单位：Rockefeller University; Tel Aviv University; Weizmann Institute of Science
• Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation of NFKBIZ mRNA AI翻译
  作者：Iguchi, Eriko; Takai, Atsushi; Oe, Natsumi; Fujii, Yosuke; Omatsu, Mayuki; Takeda, Haruhiko; Shimizu, Takahiro; Maruno, Takahisa; Nakanishi, Yuki; Yoshinaga, Masanori; Maruyama, Takashi; Marusawa, Hiroyuki; Obama, Kazutaka; Takeuchi, Osamu; Seno, Hiroshi
  作者单位：Kyoto University; Kyoto University; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR); Osaka Red Cross Hospital; Kyoto University
  摘要：Regnase- 1 is a ribonuclease that regulates inflammation in immune cells by degrading cytokine mRNA. Regnase- 1 was identified as one of the frequently mutated genes in the inflamed colorectal epithelium of patients with ulcerative colitis; however, its significance in intestinal epithelial cells during the tumorigenic process remains unknown. Therefore, we developed an ApcMin/+ mouse model lacking Regnase- 1 in intestinal epithelia. Regnase- 1 deletion significantly enhanced colon tumor growt...
• CACNA1D is a circadian gene and causes familial advanced sleep phase AI翻译
  作者：Webb, John M.; Abderemane-Ali, Fayal; Ashbrook, Liza; Ma, Mingyang; Nibber, Neha; Zou, Xianlin; Yamazaki, Maya; Wohler, Elizabeth; Sobreira, Nara; Minor Jr, Daniel L.; Fu, Ying - Hui; Ptacek, Louis J.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Johns Hopkins University; Johns Hopkins Medicine; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California San Francisco
  摘要：Familial advanced sleep phase (FASP) is a heritable human sleep trait characterized by early sleep onset and offset times. We have identified five variants in five different families in the human voltage- gated calcium channel subunit alpha1 D (CACNA1D) that cosegregate with FASP. The variants in CACNA1D lead to altered channel dynamics in vitro. A mouse model of the E427K variant has a normal circadian period under constant darkness but displays altered phase shifts in response to light in th...
• Structure-function coupling in the first month of life: Associations with age and attention AI翻译
  作者：Tooley, Ursula A.; Kenley, Jeanette K.; Camacho, M. Catalina; Latham, Aidan; Alexopoulos, Dimitrios; Nielsen, Ashley N.; Smyser, Tara A.; Warner, Barbara B.; Shimony, Joshua S.; Neil, Jeffrey J.; Luby, Joan L.; Barch, Deanna M.; Rogers, Cynthia E.; Smyser, Christopher D.
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
  摘要：How brain structure relates to function is a critical and open question in neuroscience. Here, we characterize regional variation in structure-function coupling, capturing the degree to which a cortical region's structural connections relate to patterns of coordinated neural activity in healthy, term-born neonates (n = 239). Regional structure-function coupling is heterogeneously patterned across the cortex, with higher coupling in the auditory, lateral prefrontal, and inferior parietal cortic...
• Why excluding regenerative grazing skews beef's carbon profile AI翻译
  作者：Apanovich, Nataliya; Weeks, Deseret
  作者单位：University of Arizona; Utah System of Higher Education; Utah State University
• Polaron catastrophe within quantum acoustics AI翻译
  作者：Aydin, Alhun; Keski-Rahkonen, Joonas; Graf, Anton M.; Yuan, Shaobing; Ouyang, Xiao-Yu; Muestecaplioglu, Ozguer E.; Heller, Eric J.
  作者单位：Sabanci University; Harvard University; Harvard University; Princeton University; California Institute of Technology; Koc University
  摘要：The quantum acoustic framework has recently emerged as a nonperturbative, coherent approach to electron-lattice interactions, uncovering rich physics often obscured by perturbative methods with incoherent scattering events. Here, we model the strongly coupled dynamics of electrons and acoustic lattice vibrations within this framework, representing lattice vibrations as coherent states and electrons as quantum wave packets, in a manner distinctively different from tight-binding or discrete hopp...
• MyD88 knockdown by RNAi prevents bacterial stimulation of tubeworm metamorphosis AI翻译
  作者：Darin, Emily; Farrell, Morgan v; Ali, Tatyana N.; Alfaro, Josefa Rivera; Malter, Kyle E.; Shikuma, Nicholas J.
  作者单位：California State University System; San Diego State University; California State University System; San Diego State University
  摘要：Diverse animals across the tree of life undergo the life- history transition of metamorphosis in response to bacteria. Although immunity has been implicated in this metamorphosis in response to bacteria, no functional connection has yet been demonstrated between immunity and metamorphosis. We investigated a host-microbe interaction involving Pseudoalteromonas luteoviolacea, a metamorphosis- inducing marine bacterium. By creating a marine bacteria-mediated RNA interference approach, we show tha...
• Spatially resolved DNP- assisted NMR illuminates the conformational ensemble of α- synuclein in intact viable cells AI翻译
  作者：Kragelj, Jaka; Ghosh, Rupam; Xiao, Yiling; Dumarieh, Rania; Lagasca, Dominique; Krishna, Sakshi; Frederick, Kendra K.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; National Institute of Chemistry - Slovenia
  摘要：The protein alpha- syn adopts a wide variety of conformations including an intrinsically disordered monomeric form and an alpha- helical- rich membrane- associated form that is thought to play an important role in cellular membrane processes. However, despite the high affinity of alpha- syn for membranes, evidence that the alpha- helical form is adopted inside cells has been indirect. DNP- assisted solid- state NMR on frozen cellular samples can report directly on the entire conformational ens...