28期

最新文章

• Political and biological reality checks AI翻译
  作者：Berenbaum, May R.
• Multiorgan transcriptomics in mice identifies immunoglobulin heavy constant mu (Ighm) as a tissue-level aging biomarker AI翻译
  作者：Yin, Fan-Qian; Wang, Xia-Yan; Li, Yong-Xuan; Li, Kai-Jing; Ma, Si-Yu; Lv, Meng-Jiao; Liu, Zhen-Hua; Zhong, Wei-Xia; Liu, Yan; Tang, Chuan-Fang; Liu, Hong-Shi; Li, Yuze; Xiao, Fu-Hui; Kong, Qing-Peng
  作者单位：Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Ningbo University; Chinese Academy of Sciences
  摘要：Identifying aging-associated biomarkers applicable for multiple tissues is challenging but crucial for assessing tissue aging. Here, we obtained and analyzed 456 transcriptomes on 17 organs from 30 C57BL/6 J mice with different ages, revealing the consistently upregulated mRNAs of Ighm, Cob, and Ccl8 in most aged organs. This finding received support from independent transcriptomic and proteomic datasets and was further validated through western blot, enzyme-linked immunosorbent assay (ELISA),...
• TaHSP18.6 and TaSRT1 interact to confer resistance to Fusarium crown rot by regulating the auxin content in common wheat AI翻译
  作者：Zhang, Ning; Liu, Lu; Li, Songgang; Wei, Yuhui; Ren, Wanting; Li, Mengyao; Zhao, Simin; Sun, Zhipeng; Yang, Xia; Ren, Yan; Yang, Mei; He, Guangming; Deng, Xing Wang; Chen, Feng
  作者单位：Henan Agricultural University; Peking University; Peking University; Peking University
  摘要：Fusarium crown rot (FCR) is one of the most serious soil-borne diseases in common wheat and has caused major wheat yield losses worldwide. Here, we identified an 18.6 kDa heat shock protein gene (TaHSP18.6) through combining a transcriptome analysis and a genome-wide association study. We verified the positive role of TaHSP18.6 in regulating wheat FCR resistance using ethyl methanesulfonate (EMS) mutants and genetic transformation. Next, we screened a lysine deacetylase sirtuin-like (TaSRT1) t...
• Asymptotic theory of in-context learning by linear attention AI翻译
  作者：Lu, Yue M.; Letey, Mary; Zavatone-Veth, Jacob A.; Maiti, Anindita; Pehlevan, Cengiz
  作者单位：Harvard University; Harvard University; Harvard University; Harvard University; Perimeter Institute for Theoretical Physics
  摘要：Transformers have a remarkable ability to learn and execute tasks based on examples provided within the input itself, without explicit prior training. It has been argued that this capability, known as in-context learning (ICL), is a cornerstone of Transformers' success, yet questions about the necessary sample complexity, pretraining task diversity, and context length for successful ICL remain unresolved. Here, we provide a precise answer to these questions in an exactly solvable model of ICL ...
• Competition for Hfq drives kinetic selection of mRNA targets by Escherichia coli small noncoding RNAs AI翻译
  作者：Roca, Jorjethe; Chen, Yi- Lan; Woodson, Sarah A.
  作者单位：Johns Hopkins University; Roche Holding; Roche Holding USA
  摘要：Small noncoding RNAs (sRNAs) regulate gene expression in Escherichia coli bacteria in response to diverse stimuli in the environment and the host. Most sRNAs regulate mRNA expression by directly base pairing with complementary sites in the target mRNA with the help of the chaperone protein Hfq. sRNAs and Hfq must rapidly search hundreds of candidate mRNAs for matched (cognate) targets while discriminating against noncognate targets. Here, we use single-molecule fluorescence microscopy to direc...
• Oxidative stress is a shared characteristic of ME/CFS and Long COVID AI翻译
  作者：Shankar, Vishnu; Wilhelmy, Julie; Curtis, Ellis J.; Michael, Basil; Cervantes, Layla; Mallajosyula, Vamsee; Davis, Ronald W.; Snyder, Michael; Younis, Shady; Robinson, William H.; Shankar, Sadasivan; Mischel, Paul S.; Bonilla, Hector; Davis, Mark M.
  作者单位：Stanford University; Stanford University; Stanford University; University of California System; University of California San Diego; Stanford University; Stanford University; Stanford University; Geriatric Research Education & Clinical Center; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University
  摘要：Over 65 million individuals worldwide are estimated to have Long COVID (LC), a complex multisystemic condition marked by fatigue, post-exertional malaise, and other symptoms resembling myalgic encephalomyelitis/chronic fatigue syndrome (ME/ CFS). With no clinically approved treatments or reliable diagnostic markers, there is an urgent need to define the molecular underpinnings of these conditions. By studying bioenergetic characteristics of peripheral blood lymphocytes in 25 healthy controls, ...
• Reply to Pang et al.: Generalizable ability to track beliefs could be the most parsimonious explanation AI翻译
  作者：Kosinski, Michal
  作者单位：Stanford University
• What you C is what you get AI翻译
  作者：Holland, Patrick L.
  作者单位：Yale University
• Motilin stimulates food intake linked to gastric motility in Suncus murinus: Simultaneous recordings of food intake and gastric motility in the conscious state AI翻译
  作者：Huang, Jin; Watanabe, Ayumi; Kanaya, Moeko; Gomi, Ayano; Yokoyama, Haruka; Ishii, Hikari; Nakamura, Yusuke; Azuma, Morio; Konno, Norifumi; Kaiya, Hiroyuki; Sakai, Takafumi; Sakata, Ichiro
  作者单位：Saitama University; Jichi Medical University; University of Toyama; Saitama University; Saitama University
  摘要：The intestinal-derived hormone motilin, a peptide belonging to the ghrelin family, induces strong gastric contractions and hunger sensations. However, whether motilin regulates food intake and its association with gastric motility remains unclear. Rodents are unsuitable for animal studies of motilin function, as both the motilin and motilin-receptor genes exist only as pseudogenes in their genomes. In this study, investigated the role of motilin on food intake by simultaneously monitoring gast...
• The evolution of male-female dominance relations in primate AI翻译
  作者：Huchard, Elise; Kappeler, Peter M.; Smit, Nikolaos; Fichtel, Claudia; Lukas, Dieter
  作者单位：Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; Leibniz Association; Deutsches Primatenzentrum (DPZ); University of Gottingen; Max Planck Society
  摘要：Historically, it was widely assumed that males dominate females socially in most mammals. However, recent studies revealed significant variation within and among species, opening new possibilities to explore the extent and drivers of sex biases in dominance relations. This study uses quantitative data from 253 populations across 121 primate species to investigate the distribution of, and factors associated with, sex biases in the outcome of male-female contests. We first showed that male-femal...