28期

最新文章

• Cell-to-cell translocation of florigen is inhibited by low ambient temperature through abscisic acid signaling in Arabidopsis thaliana AI翻译
  作者：Murata, Yusuke; Nagata, Kenji; Abe, Mitsutomo
  作者单位：University of Tokyo
  摘要：In Arabidopsis thaliana, the FLOWERING LOCUS T (FT) gene encodes florigen, a floral stimulus that integrates multiple environmental cues to optimize the timing of flowering, which is crucial for reproductive success. The FT protein is synthesized in the phloem companion cells of leaves but exerts its function in the shoot apical meristem (SAM) to initiate floral morphogenesis. While the environment-dependent regulation of FT transcription in leaves is well studied, the mechanisms underlying FT...
• WT1 directs normal progesterone receptor-chromatin binding essential for uterine receptivity at peri- implantation AI翻译
  作者：Ni, Zhangli; Guo, Chuanhui; Liu, Xiaojing; Li, Gaizhen; Tang, Yedong; Cai, Han; Huang, Weiyu; Gao, Fei; Tu, Zhaowei; Wang, Chao; Wang, Haibin; Kong, Shuangbo; Bao, Haili
  作者单位：Xiamen University; China Agricultural University; Chinese Academy of Sciences; Institute of Zoology, CAS; Guangzhou Medical University; Xiamen University
  摘要：Progesterone receptor (PR)- mediated progesterone (P4) signaling plays a crucial role in the establishment of uterine receptivity which is the prerequisite for successful embryo implantation in mammals. However, detailed molecular mechanisms underlying PR-chromatin binding and transcriptional activity in the uterus remain largely elusive. Here, combining the P4- administrated ovariectomized mouse model and PR-chromatin immunoprecipitation sequencing, we identified transcription factor WT1 as a...
• The pathogenic factor of ZC4H2-associated rare disorder is a postsynaptic regulator for synaptic activity and cognitive function AI翻译
  作者：Wan, Li Pear; Li, Yuwei; Zhao, Shuhua; Zhao, Shiping; Song, Ning - Ning- Ning; Yang, Cuiping; Ding, Yu- Qiang; Yuan, Kai-Ming; Mao, Bingyu; Sheng, Nengyin; Tao, Wucheng; Ma, Pengcheng
  作者单位：Fujian Medical University; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Kunming Medical University; Fudan University; Wenzhou Medical University; Wenzhou Medical University; Shanghai Jiao Tong University; Fudan University; Fudan University; Chinese Academy of Sciences; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences
  摘要：The maintenance of excitatory synaptic activity is crucial for cognitive function and genetic mutations are responsible for the pathogenesis of related brain disorders. However, the roles of these pathogenic factors in synaptic dysregulation and cognitive malfunction are still poorly understood. In this study, a conditional knockout mouse model lacking ZC4H2-an X-linked gene implicated in ZC4H2-associated rare disorder (ZARD) -in forebrain excitatory neurons is generated and these mice exhibit...
• Confinement of ions within graphene oxide membranes enables neuromorphic artificial AI翻译
  作者：Zhang, Yuchun; Liu, Lin; Qiao, Yu; Yao, Tian; Zhao, Xing; Yan, Yong
  作者单位：Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shandong University of Technology; University of Science & Technology Beijing
  摘要：Introducing neuromorphic computing paradigms into taste-sensing technology will bring unprecedented opportunities for developing new hardware architectures with perceptual intelligence. Constructing the biomimetic gustatory system, however, remains a challenge due to the scarcity of suitable components operating under wet conditions. Here, we report that ion confinement within the layered graphene oxide membranes can be used to develop a memristive device capable of implementing both synaptic ...
• Including the gender dimension of migration is essential to avoid systematic bias in migration predictions AI翻译
  作者：Anastasiadou, Athina; Zagheni, Emilio; de Valk, Helga A. G.
  作者单位：Max Planck Society; University of Groningen; Royal Netherlands Academy of Arts & Sciences; Netherlands Interdisciplinary Demographic Institute (NIDI-KNAW)
  摘要：This study examines the theoretical and methodological limitations of migration research in understanding gender-specific trends of migration. In particular, theory-driven methods suffer from the gender blindness of migration theories, while data-driven methods suffer from the scarcity of gender disaggregated migration data. This research aims to evaluate how these dual limitations affect the accuracy of commonly used migration prediction models. By analyzing migration flows disaggregated by g...
• Osteoinductive low- dose 3D porous calcium phosphate graphene oxide-integrated matrices enhance osteogenesis and mechanical properties AI翻译
  作者：Hosseini, Fatemeh S.; Whitfield, Taraje; Orlando, Jason D.; Deng, Chenyun; Abedini, Amir A.; Argyrou, Chrysoula; Kan, Ho - Man; Ghosh, Debolina; Maye, Peter F.; Lo, Kevin W. - H.; Nair, LakshmiS.; Sydlik, Stefanie A.; Laurencin, Cato T.
  作者单位：University of Connecticut; University of Connecticut; Carnegie Mellon University; Carnegie Mellon University; University of Connecticut; University of Connecticut; University of Connecticut; University of Connecticut
  摘要：Bone regeneration continues to be a challenge due to the complex nature of the tissue. Identifying new materials that stimulate regeneration while providing mechanical properties is an active area of research. One class of promising material in bone regeneration is graphene and its derivatives including graphene oxide (GO), the oxidized form of graphene. Recently, calcium phosphate graphene (CaPG), synthesized from GO, has been proven to have osteoinductive properties in vivo. However, CaPG is...
• Unveiling the charge transport blockade in the D2 branch of the photosystem II reaction center AI翻译
  作者：Mandal, Aditya Kumar; Basera, Shubham; Goddard III, William A.; Maiti, Prabal K.
  作者单位：Indian Institute of Science (IISC) - Bangalore; California Institute of Technology
  摘要：Photosynthesis, the fundamental process sustaining life on Earth, depends on the photosystem II (PSII) reaction center's ability to initiate the charge transport process. In this study, we have investigated this charge transport process with a focus on the dissimilarity between the two branches of the PSII reaction center, D1 and D2. Utilizing Marcus theory, we have calculated the reorganization energies and activation barriers for all the key steps involved in the charge transport process. Ou...
• EDNRB2 regulates fate, migration, and maturation of hair cell precursors in regenerating avian auditory epithelium explants AI翻译
  作者：Takeuchi, Marie; Matsunaga, Mami; Kita, Tomoko; Nishimura, Koji; Tona, Yosuke; Omori, Koichi; Katsuno, Tatsuya; Nakagawa, Takayuki
  作者单位：Kyoto University; Kyoto University
  摘要：The mammalian cochlea loses its ability to regenerate hair cells (HCs) after birth. In contrast, in the avian auditory epithelium, the basilar papilla (BP), supporting cells (SCs) retain the capability for HC regeneration throughout life. Our previous study using single-cell RNA sequencing indicated a stepwise fate conversion of SCs to HCs via a precursor state, in which endothelin receptor type B2 (EDNRB2) exhibited specifically high expression during HC regeneration in chick BP. This study a...
• SHANK2 establishes auditory hair bundle architecture essential for mammalian hearing AI翻译
  作者：Choi, Han Seul; Park, Hyeyoung; Min, Hyehyun; Kim, Kwan Soo; Kim, Soo Min; Li, Jinan; Liu, Chang; Ko, Hyuk Wan; Lee, Min Goo; Song, Lei; Zhao, Bo; Bok, Jinwoong
  作者单位：Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; Indiana University System; Indiana University Bloomington; Yonsei University; Yonsei University; Yonsei University Health System; Shanghai Jiao Tong University; Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System
  摘要：The mammalian auditory system relies on the precise architecture of the hair cell stereociliary bundle for effective sound transduction. Each bundle consists of approximately 100 actin-filled stereocilia arranged in a three-row staircase pattern, forming a linear shape in inner hair cells (IHCs) and a V-shape in outer hair cells (OHCs), the latter geometry being a hallmark of the mammalian cochlea. While the initial development from uniformly distributed microvilli into stereociliary bundles i...
• HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise AI翻译
  作者：Ehrlich, Amy M.; MacGregor, Kirstin A.; Ashcroft, Stephen P.; Small, Lewin; Altintas, Ali; Chibalin, Alexander V.; Anagho-Mattanovich, Matthias; Stocks, Ben; Moritz, Thomas; Treebak, Jonas T.; Zierath, Juleen R.
  作者单位：University of Copenhagen; Karolinska Institutet; Karolinska Institutet
  摘要：The regulation of metabolism in peripheral tissues is intricately linked to circadian rhythms, with hypoxia-inducible factor-1 alpha (HIF1 alpha) implicated in modulating time-of-day-specific exercise responses. To investigate this relationship, we generated a skeletal muscle-specific HIF1 alpha knockout (KO) mouse model and performed extensive metabolic phenotyping and transcriptomic profiling under both basal conditions and following acute exercise during early rest (ZT3) and active (ZT15) p...