-
作者：Shaked, Ron; Katz, Michael; Dvashi, Hadas Cohen -; Diskin, Ron
作者单位：Weizmann Institute of Science
摘要：The human endogenous retrovirus K (HERV-K) is a retrovirus that got assimilated into the human genome in ancient times and has been inherited in our germline ever since. It enters cells using a class-I spike protein (Env) that mediates receptor recognition and membrane fusion. On top of having a biological role during development, HERV-K is activated in amyotrophic lateral sclerosis, various cancers, and other pathological conditions. Antibodies that target the HERV-K spike complex have therap...
-
作者：Bontrager, Megan; Worthy, Samantha J.; Cacho, N. Ivalu; Leventhal, Laura; Maloof, Julin N.; Gremer, Jennifer R.; Schmitt, Johanna; Strauss, Sharon Y.
作者单位：University of California System; University of California Davis; University of California System; University of California Davis; University of Toronto; University of Nebraska System; University of Nebraska Lincoln; Universidad Nacional Autonoma de Mexico; Carnegie Institution for Science; Stanford University; University of California System; University of California Berkeley; University of California System; University of California Davis
摘要：Quantifying species' niches across a clade reveals how environmental tolerances evolve, and offers insights into present and future distributions. We use herbarium specimens to explore climate niche evolution across 14 annual species of the Streptanthus (s.l.) clade (Brassicaceae), which originated in deserts and diversified into cooler, moister areas. To understand how climate niches evolved, we used historical climate records to estimate each species' 1) classic annual climate niche, average...
-
作者：Crosby, Garrett S.; Hei, Bai; Lynn, Melissa L.; Chakraborti, Ananya; Schwartz, Steven D.; Tardiff, Jil C.
作者单位：University of Arizona; University of Arizona; University of Arizona
摘要：The C-terminal tail of cardiac troponin T (C-cTnT) inhibits thin filament activation and is a hotspot for cardiomyopathic mutations and variants. The mechanism whereby this region limits activation is not well understood. The last 16 C-terminal residues form a highly flexible and disordered domain and thus have been poorly resolved in studies to date. Using Time-Resolved fluorescence resonance energy transfer (TR-FRET) we resolved the structure of the disordered C-cTnT and studied the structur...
-
作者：Wan, Allison; Riedl, Christoph; Lazer, David
作者单位：Northeastern University; Northeastern University; Northeastern University; Northeastern University; Harvard University
摘要：How does social network structure amplify or stifle behavior diffusion? Existing theory suggests that when social reinforcement makes the adoption of behavior more likely, it should spread more-both farther and faster-on clustered networks with redundant ties. Conversely, if adoption does not benefit from social reinforcement, it should spread more on random networks which avoid such redundancies. We develop a model of behavior diffusion with tunable probabilistic adoption and social reinforce...
-
作者：Choi, Hyewon; Cha, Youngjae; McCullough, Michael E.; Coles, Nicholas A.; Oishi, Shigehiro
作者单位：Kyung Hee University; University of Chicago; University of California System; University of California San Diego; State University System of Florida; University of Florida
摘要：Gratitude practice is a popular strategy for promoting happiness worldwide. However, is it equally effective for people from different cultural backgrounds? To answer this question, we conducted a preregistered meta-analysis on the effectiveness of gratitude interventions on well-being across cultures. Using data from 145 papers, 163 samples, 727 effect sizes, and 24,804 participants from 28 countries, we found that gratitude interventions led to small overall increases in well-being, Hedges' ...
-
作者：Juel, Mikkelmetzsch; Malthe-Sorenssen, Anders; Sveinsson, Henrik Andersen
作者单位：University of Oslo; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research
摘要：The friction force typically increases linearly with normal load with a constant of proportionality called the coefficient of friction. Most materials exhibit a positive friction coefficient, so that an increase in the normal load leads to an increase in the friction force. Recently, materials with negative friction coefficients have been observed at meticulously constructed interfaces due to an interplay between superstructures at heterojunctions, out-of-plane buckling, or the ordering of thi...
-
作者：Miller, Grant; Shane, Jack; Snipp, C. Matthew
作者单位：Stanford University; National Bureau of Economic Research; Stanford University; Stanford University
摘要：In contrast to earlier US policies of open war, forcible removal, and relocation individually titled plots of land rather than members of collective tribes with communal land. Considerable scholarship shows that the consequences of the policy differed substantially from its stated goals, and by the time of its repeal in 1934, American Indians had lost two-thirds of all native land held in 1887 (86 million acres)-and nearly two-thirds of American Indians had become landless or unable to meet su...
-
作者：Zhang, Yuxuan; Wang, Jinjin; Qing, Guangchao; Wang, Yongchao; Li, Xianlei; Luo, Ting; Wang, Yi - Feng; Liu, Lu; Wang, Yufei; Ni, Qiankun; Li, Shuyi; Chen, Junge; Li, Fangzhou; Guo, Weisheng; Zhang, Jinchao; Gong, Ningqiang; Liang, Xing - Jie
作者单位：Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Guangzhou Medical University; Guangzhou Medical University; Hebei University; Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：Cancer immunotherapy has shown tremendous promise in various cancers. However, current strategies, such as immune checkpoint blockade, primarily restore exhausted T cells but provide only transient efficacy, as the rapid clearance of antibodies. Their limited durability is further hindered by persistent T cell-tumor cell interactions that accelerate T cell exhaustion. To prevent T cells from sustained exposure to these interactions, we present a hydrogel-based biomimetic physical barrier (BPB)...
-
作者：Zhu, Zhengyang; Wang, Han; Li, Tiexiang; Huang, Tsung- Ming; Yang, Huiquan; Tao, Zhennan; Tan, Zhong-Heng; Zhou, Jianan; Chen, Sixuan; Ye, Meiping; Zhang, Zhiqiang; Li, Feng; Liu, Dongming; Wang, Maoxue; Lu, Jiaming; Zhang, Wen; Li, Xin; Chen, Qian; Jiang, Zhuoru; Chen, Futao; Zhang, Xin; Lin, Wen- Wei; Yau, Shing-Tung; Zhang, Bing
作者单位：Nanjing University; Southeast University - China; Southeast University - China; Nanjing Center for Applied Mathematics; Shanghai Institute for Mathematics & Interdisciplinary Sciences; National Taiwan Normal University; Nanjing University; Nanjing University; Tsinghua University; Nanjing University; Nanjing University
摘要：Glioma is the most common primary malignant brain tumor and preoperative genetic profiling is essential for the management of glioma patients. Our study focused on tumor regions segmentation and predicting the World Health Organization (WHO) grade, isocitrate dehydrogenase (IDH) mutation, and 1p/19q codeletion status using deep learning models on preoperative MRI. To achieve accurate tumor segmentation, we developed an optimal mass transport (OMT) approach to transform irregular MRI brain imag...
-
作者：Hanken, James
作者单位：Harvard University; Harvard University
