28期

最新文章

• Decoding and engineering temperature-sensitive lethality in Ceratitis capitata for pest control AI翻译
  作者：Aumann, Roswitha A.; Gouvi, Georgia; Gregoriou, Maria - Eleni; Rehling, Tanja; Sollazzo, Germano; Bourtzis, Kostas; Schetelig, Marc F.
  作者单位：Imperial College London; Justus Liebig University Giessen; Justus Liebig University Giessen; International Atomic Energy Agency; University of Patras
  摘要：The Sterile Insect Technique (SIT) is a species-specific and environmentally friendly method for effectively controlling pest insect populations based on releasing reared, sterile insects into infested areas. Sex sorting in rearing facilities, enabling male-only releases, is necessary to ensure SIT programs are efficient, cost-effective and, in case of mosquito control, also safe. This can be greatly facilitated by genetic sexing strains (GSS), exhibiting sex-specific phenotypic markers. Howev...
• Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase- independent mechanism AI翻译
  作者：Crawford, Conor J.; Tomlinson, Charles W. E.; Gunawan, Christian; Chen, Zongjia; Byrne, Dominic P.; Darby, Cosette; Conti, Martina L. G.; Larson, Tony; Luis, Ana S.; Elli, Stefano; Yates, Edwin A.; Bolam, David N.; van der Post, Sjoerd; Williams, Spencer J.; Cartmell, Alan
  作者单位：Max Planck Society; University of York - UK; University of York - UK; University of York - UK; University of Melbourne; University of Melbourne; University of Liverpool; Newcastle University - UK; University of Gothenburg; SciLifeLab; University of Gothenburg
  摘要：Excessive degradation of the colonic mucin layer by Bacteroides within the human gut microbiota drives inflammatory bowel disease (IBD) in mice. Bacterial carbohydrate sulfatases are key enzymes in gut colonization, and they are elevated in human IBD and correlate with disease severity.Selective inhibitors of carbohydrate sulfatases could function as sulfatase-selective drugs, allowing precise control of sulfatase activity while preserving these otherwise beneficial bacteria. Arylsulfamates ar...
• Revealing the structure of snowflakes using acoustic levitation AI翻译
  作者：Mason, Nigel John
  作者单位：University of Kent
• Do large language models have a theory of mind? AI翻译
  作者：Pang, Damian K. F.; Pang, Severin K. Y.; Broeker, Marianne D.; Hibble, Alix
  作者单位：University of Oxford; University of St Andrews
• Stress-mediated growth determines Escherichia coli division site morphogenesis AI翻译
  作者：Pelech, Petr; Navarro, Paula P.; Vettiger, Andrea; Chao, Luke H.; Allolio, Christoph
  作者单位：Charles University Prague; University of Lausanne; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：In order to proliferate, bacteria must remodel their cell wall at the division site. The division process is driven by the enzymatic activity of peptidoglycan synthases and hydrolases around the constricting Z-ring. We introduce a morphoelastic model that correctly reproduces the shape of the division site during the constriction and septation phases of Escherichia coli. In the model, mechanical stress directs the transformation of the bacterial wall. The two constants associated with growth a...
• p63 and ZNF148 cooperate to regulate head and neck squamous cell carcinoma AI翻译
  作者：Pecorari, Rosalba; Mancini, Mara; Smirnov, Artem; Corleone, Giacomo; Novelli, Flavia; Lena, Anna Maria; Canonico, Mariacristina Franzese; Montanaro, Manuela; Cappello, Angela; Sacconi, Andrea; Misso, Gabriella; Falco, Michela; Tammaro, Chiara; Ciccosanti, Fabiola; Piacentini, Mauro; Scimeca, Manuel; Caraglia, Michele; Blandino, Giovanni; Mauriello, Alessandro; Fanciulli, Maurizio; Melino, Gerry; Candi, Eleonora
  作者单位：IRCCS Istituto Dermopatico dell'Immacolata (IDI); University of Rome Tor Vergata; University of Hawaii System; Cancer Research Center of Hawaii; Universita della Campania Vanvitelli
  摘要：Head and neck squamous cell carcinoma (HNSCC) is a common and aggressive malignancy. While significant advances have been made in the management of low-grade cancer, treatment of advanced HNSCC remains challenging. Here, we used a proteomic approach to find binding partners of the oncogene p63, the most frequently amplified transcription factor in HNSCC. We identified a zinc finger protein, ZNF148, which is coexpressed and physically binds p63 in carcinoma cells. Genome occupancy analyses iden...
• Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal AI翻译
  作者：Beerendonk, Lola; Mejias, Jorge F.; Nuiten, Stijn A.; de Gee, Jan Willem; Zantvoord, Jasper B.; Fahrenfort, Johannes J.; van Gaal, Simon
  作者单位：University of Amsterdam; University of Amsterdam; University of Amsterdam; University of Basel; University of Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
  摘要：Performance typically peaks at moderate arousal levels, consistent with the Yerkes-Dodson law, as confirmed by recent human and mouse pupillometry studies. Arousal states are influenced by neuromodulators like catecholamines (noradrenaline and dopamine) and acetylcholine. To investigate their contributions to this law, we pharmacologically enhanced arousal while measuring human decision-making and spontaneous arousal fluctuations via pupil size. The catecholaminergic agent atomoxetine increase...
• Piezo2+ mechanosensory neurons orchestrate postnatal development through mechano-chemo-transduction of PDGFA signaling AI翻译
  作者：Meng, Lin; Feng, Jifan; Guo, Tingwei; Zhang, Mingyi; Cha, Sa; Chen, Peng; Ziaei, Heliya; Harouni, Aaron; Ho, Thach - Vu; Chai, Yang
  作者单位：University of Southern California; Jilin University
  摘要：Mechanical forces are ubiquitous and essential during vertebrate development, yet how these forces are translated into biochemical signals and regulate development during postnatal organogenesis remains poorly understood. While early embryogenesis relies on cell-autonomous mechanotransduction, the role of sensory innervation-abundant in postnatal stages-has been overlooked. Here, using the postnatal mouse molar development model, a system experiencing sustained mechanical forces and extensive ...
• Population size interacts with reproductive longevity to shape the germline mutation rate (vol 122, e2423311122, 2025) AI翻译
  作者：Zhu, Luke; Beichman, Annabel; Harris, Kelley
• Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy AI翻译
  作者：Barnet, Megan B.; L., Katherine J.; Masle, Etienne; Russell, Amanda; Burnett, Deborah L.; Chye, Adrian; Jara, Chris J.; Faulks, Megan; Mawson, Amanda; Peters, Timothy J.; Brink, Robert; Wright, Katherine; Allen, India; Junankar, Simon; Davis, Ian D.; Heller, Gillian; Khan, Zia; Bruce, Jeffrey; Yang, Cindy; Prokopec, Stephenie; Pugh, Trevor; Behren, Andreas; Hold, Georgina L.; Zhang, Fan; Cooper, Wendy A.; Gao, Bo; Nagrial, Adnan; Joshua, Anthony M.; John, Thomas; Peters, Geoffrey; Hui, Rina; Boyer, Michael; Blinman, Prunella L.; Kao, Steven C.; Cebon, Jonathan; Goodnow, Christopher C.
  作者单位：Garvan Institute of Medical Research; University of New South Wales Sydney; NSW Health; St Vincents Hospital Sydney; The Kinghorn Cancer Centre; University of Technology Sydney; University of New South Wales Sydney; University of New South Wales Sydney; Monash University; La Trobe University; Olivia Newton-John Cancer Research Institute; Eastern Health; University of Sydney; Roche Holding; Genentech; Roche Holding USA; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; La Trobe University; University of Melbourne; University of New South Wales Sydney; Western Sydney University; University of Sydney; NSW Health; Royal Prince Alfred Hospital; University of Sydney; NSW Health; Blacktown & Mount Druitt Hospital; University of Sydney; NSW Health; Westmead Hospital; Peter Maccallum Cancer Center; Chris O'Brien Lifehouse; Concord Repatriation General Hospital
  摘要：Lung cancers and melanomas have many somatically mutated self-proteins that would be expected to trigger an immune rejection response, yet therapeutic responses can only be induced in a subset of patients. Here, we investigated the possibility that inherited differences in immune tolerance checkpoints contribute to variability in outcomes. Whole genome sequencing revealed biallelic germline loss-of-function (LOF) mutations in the immune tolerance checkpoint gene, NOD2, in an exceptional immune...