28期

最新文章

• Noncoding RNAs have a key role in butterfly speciation. What about other flora and fauna? AI翻译
  作者：Bolakhe, Saugat
• A conserved editing mechanism for the fidelity of bacterial cell wall biosynthesis AI翻译
  作者：Garde, Shambhavi; Selvaraj, Harikrishnan; Chandramouli, Aakash; Reddy, Gundlapally S.; Bahety, Devesh; Chodisetti, Pavan Kumar; Kamat, Siddhesh S.; Reddy, Manjula
  作者单位：Council of Scientific & Industrial Research (CSIR) - India; CSIR - Centre for Cellular & Molecular Biology (CCMB); Indian Institute of Science Education & Research (IISER) Pune; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Scripps Research Institute
  摘要：Peptidoglycan (PG), a defining feature of the bacterial cell envelope, is crucial for cell integrity and morphology. PG is a macromolecular mesh consisting of glycan polymers crosslinked by short peptides encasing the cytoplasmic membrane. PG peptides contain two to five amino acids of both L- and D- configuration, with a conserved L- alanine residue at the first position in most bacteria. We previously identified a beta- lactam hypersensitive mutant of Escherichia coli lacking yfiH (renamed p...
• QnAs with Janet B. Pierrehumbert AI翻译
  作者：Ravindran, Sandeep; Pierrehumbert, Janet B.
• Declining winter snowpack offsets carbon storage enhancement from growing season warming in northern temperate forest ecosystems AI翻译
  作者：Rooney, Emerson Conrad-; Reinmann, Andrew B.; Templer, Pamela H.
  作者单位：Boston University; City University of New York (CUNY) System; City University of New York (CUNY) System; City University of New York (CUNY) System; City University of New York (CUNY) System; Hunter College (CUNY)
  摘要：Northeastern US temperate forests are currently net carbon (C) sinks and play an important role offsetting anthropogenic C emissions, but projected climatic changes, including increased temperatures and decreased winter snowpack, may influence this C sink over the next century. Past studies show that growing season warming increases forest C storage through greater soil nutrient availability that contributes to greater rates of net photosynthesis, while reduced winter snowpack induces soil fre...
• Sustainable synthesis of polymer- grade ethylene via electrified acetylene semihydrogenation AI翻译
  作者：Yan, Zihao; Xu, Libang; Zhu, Huiyuan
  作者单位：University of Virginia; University of Virginia
  摘要：The electrocatalytic semihydrogenation of acetylene (C2H2), powered by renewable electricity, provides an energy-and cost-efficient alternative to conventional thermocatalytic methods for purifying crude ethylene (C2H4) streams. This approach provides a more sustainable route to polymer-grade C2H4 by reducing greenhouse gas emissions, yet its commercial potential remains limited by the scarcity of high-performance catalysts and the absence of comprehensive techno-economic analyses for large-sc...
• Multiarea processing in body patches of the primate inferotemporal cortex implements inverse graphics AI翻译
  作者：Yilmaz, Hakan; Shah, Aalap D.; Letrou, Ariadne; Kumar, Satwant; Vogels, Rufin; Yildirim, Ilker
  作者单位：Yale University; Princeton University; KU Leuven; KU Leuven; Yale University; Yale University; Yale University
  摘要：Stimulus-driven, multiarea processing in the inferotemporal (IT) cortex is thought to be critical for transforming sensory inputs into useful representations of the world. What are the formats of these neural representations and how are they computed across the nodes of the IT networks? A growing literature in computational neuroscience focuses on the computational-level objective of acquiring high-level image statistics that supports useful distinctions, including between object identities or...
• Genetic ancestry shapes dengue virus infection in human skin explants AI翻译
  作者：Castanha, Priscila M. S.; Marti, Michelle M.; Duangkhae, Parichat; Taddonio, Jocelyn M.; Cooper, Kristine L.; Wallace, Megan; Kettenburg, Gwenddolen; Erdos, Geza; Chavva, Hasitha; Alex, Aleena; Rubin, J. Peter; Watkins, Simon C.; Falo Jr, Louis D.; Marques, Ernesto T. A.; Martinson, Jeremy J.; Boyes, Simon M. Barratt -
  作者单位：University of Chicago; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Fundacao Oswaldo Cruz
  摘要：Dengue is the most prevalent arthropod-borne viral disease of humans, with over half the world's population at risk. Infection with any of the four dengue virus (DENY) serotypes is most often self-limiting, but a significant number of cases present with severe dengue characterized by vascular leakage that may be fatal. African ancestry is associated with protection against severe dengue, but the mechanisms are unknown. Using skin explants from genetically defined donors, we show that European ...
• An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates AI翻译
  作者：Fallot, Lucas B.; Pinc, Johnathan R.; Buselmeier, Joseph E.; Palchak, Julia C.; Shroff, Supria S.; Zang, Kaitlyn; Rinauro, Dillon J.; Bacon, Kate M.; Nguyen, Michael; Schleck, Mary Claire; Cornell, Alyssa R.; Oshidar, Alexandra; Darrell, Donald J.; Gabriel, Justus M.; Wright, Aidan K.; Sasser, Liam R.; Kreiser, Ryan P.; Burpo, F. John; Santambrogio, Alessia; Xu, Peifeng; Kubiak II, Robert W.; Loverde, Joseph; A.Jaffett, Victor; Toole, Justin R.; Barbut, Denise; Zasloff, Michael; Chiti, Fabrizio; Dear, AlexanderJ.; Vendruscolo, Michele; Limbocker, Ryan
  作者单位：United States Military Academy; United States Department of Defense; United States Army; United States Military Academy; United States Department of Defense; United States Army; University of Cambridge; Georgetown University; University of Florence; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Aberrant aggregates of the 42-residue form of the amyloid-f3 peptide (Af342) are cytotoxic in Alzheimer's disease (AD). Cost-effective and chronically safe disease-modifying therapeutics are needed to address the AD medical emergency worldwide. To increase our understanding of the mechanisms of Af342-induced cytotoxicity and to investigate clinically relevant aminosterols, we study the impact of claramine on the aggregation kinetics and properties of Af342 aggregates, as well as the ability of...
• Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial- to- hematopoietic transition (vol 110, pg E141, 2012) AI翻译
  作者：Kim, Peter Geon; Albacker, Colleen E.; Lu, Yi-fen; Jang, Il-ho; Lim, Yoowon; Heffner, Garrett C.; Arora, Natasha; Bowman, Teresa V.; Lin, Michelle I.; Lensch, M. William; De Los Angeles, Alejandro; Zon, Leonard I.; Loewer, Sabine; Daley, George Q.
• The WWP1-JARID1B axis sustains acute myeloid leukemia chemoresistance AI翻译
  作者：Fierro, Claudia; Giovannini, Sara; Moriconi, Valeria; Fiorilli, Claudia; Panatta, Emanuele; Frezza, Valentina; Corigliano, Federica; Pecorari, Rosalba; Li, Yanan; Zhou, Ji; Delvecchio, Vincenza Simona; Smirnov, Artem; Manteiga, Jose Manuel Garcia; Brendolan, Andrea; Zhang, Jinping; Shi, Yufang; Amelio, Ivano; Candi, Eleonora; Melino, Gerry; Bernassola, Francesca
  作者单位：University of Rome Tor Vergata; IRCCS Istituto Dermopatico dell'Immacolata (IDI); Soochow University - China; Soochow University - China; IRCCS Ca Granda Ospedale Maggiore Policlinico; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Konstanz
  摘要：To uncover substrates mediating the oncogenic activity of WWP1 in acute myeloid leukemia (AML), we performed a proteomic analysis that identified the histone demethylase KDM5B/JARID1B as a candidate target. Of note, JARID1B is indispensable for efficient recruitment of several DNA damage repair factors and for damage resolution, thus negatively influencing the sensitivity of cancer cells to chemo-and radiation therapies. Validation of JARID1B as a substrate of WWP1 revealed a positive regulati...