28期

最新文章

• A chemoreceptor conformational equilibrium controlled by signaling inputs AI翻译
  作者：Hoffman, Mikaila C.; Li, Mingshan; Hazelbauer, Gerald L.; Schlau-Cohen, Gabriela S.
  作者单位：Massachusetts Institute of Technology (MIT); University of Missouri System; University of Missouri Columbia
  摘要：In chemotaxis, motile bacteria recognize external molecules and move toward favorable ling, control a histidine kinase, and undergo posttranslational adaptational modifications. Chemoreceptors are thought to function by switching between two signaling states: kinase- off, favored by ligand occupancy, and kinase- on, favored by adaptational modification. Many structural and biochemical features of the two states have been identified, but little is known about the equilibrium between them and th...
• AI-driven design of multiprincipal element alloys for optimal water splitting AI翻译
  作者：Kim, Jihoon; Kim, Dong Won; Choi, Jong Hui; Goddard III, William A.; Kang, Jeung Ku
  作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); California Institute of Technology
  摘要：Water splitting for hydrogen production is essential in advancing the hydrogen economy. Multiprincipal element alloys offer promising opportunities for optimizing this process, yet their vast compositional space and the presence of local minima pose significant challenges for experimental and AI-driven exploration. To overcome these challenges, an AI framework is developed by integrating Gaussian Process Regression with a configuration entropy-based acquisition function for screening and a des...
• Inferring coexistence likelihood in changing environments from ecological time series AI翻译
  作者：Nguyen, Phuong L.; Pomati, Francesco; Rohr, Rudolf P.
  作者单位：University of Fribourg; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG)
  摘要：Inferring coexistence metrics, such as niche and fitness differences, in changing environments is key for understanding the mechanism behind species coexistence and predicting its likelihood. However, it first requires estimating the per capita interactions between organisms and their intrinsic growth rates-parameters that are typically measured by isolating organisms from their natural context. Here, we first use weighted multivariate regression on the per capita growth rates of populations t...
• Expressing intentions is not climate action AI翻译
  作者：Dablander, Fabian; Lange, Florian; Brick, Cameron; Aron, Adam R.
  作者单位：University of Amsterdam; University of Amsterdam; KU Leuven; University of Amsterdam; University of California System; University of California San Diego
• Genome analyses suggest recent speciation and postglacial isolation in the Norwegian lemming AI翻译
  作者：Lord, Edana; Feinauer, Isabelle S.; Soares, Andre E. R.; Lagerholm, Vendela K.; Naesvall, Karin; Ersmark, Erik; Olsen, Remi- Andre; Prost, Stefan; Kuzmina, Elena A.; Smirnov, Nickolay G.; Stewart, John R.; V. Knul, Monika; Noiret, Pierre; Germonpre, Mietje; Ehrich, Dorothee; Pokrovsky, Ivan; Fedorov, Vadim B.; V. Goropashnaya, Anna; Dalen, Love; Diez-del-Molino, David
  作者单位：Swedish Museum of Natural History; Stockholm University; Swedish Museum of Natural History; Uppsala University; Stockholm University; Wellcome Trust Sanger Institute; Stockholm University; University of Vienna; South African National Biodiversity Institute; Russian Academy of Sciences; Institute of Plant & Animal Ecology of the Russian Academy of Sciences; Bournemouth University; University of Winchester; University of Liege; Royal Belgian Institute of Natural Sciences; UiT The Arctic University of Tromso; Max Planck Society; University of Alaska System; University of Alaska Fairbanks
  摘要：The Norwegian lemming (Lemmus lemmus) is a small rodent distributed across the Fennoscandian mountain tundra and the Kola Peninsula. The Norwegian lemming likely evolved during the Late Pleistocene and inhabited Fennoscandia shortly prior to the Last Glacial Maximum. However, the exact timing and origins of the species, and its phylogenetic position relative to the closely related Siberian lemming (Lemmus sibiricus) remain disputed. Moreover, the presence of ancient or contemporary gene flow b...
• Mycophenolic acid treatment drives the emergence of novel SARS-CoV-2 variants AI翻译
  作者：Meister, Toni Luise; Nocke, Maximilian K.; Heinen, Natalie; Burkard, Thomas L.; Brueggemann, Yannick; Westhoven, Saskia; Trueb, Bettina; Ebert, Nadine; Thomann, Lisa; Lubieniecki, Krzysztof P.; Lubieniecka, Joanna M.; Doering, Kristina; Herrmann, Maike; Haid, Sibylle; Pietschmann, Thomas; Wiegmann, Bettina; Tao, Ronny; Pfefferle, Susanne; Addo, Marylyn M.; Thiel, Volker; Drexler, Ingo; Babel, Nina; Nguyen, Huu Phuc; Brown, Richard J. P.; Todt, Daniel; Steinmann, Elike; Pfaender, Stephanie
  作者单位：Ruhr University Bochum; University of Hamburg; University Medical Center Hamburg-Eppendorf; Leibniz Association; Bernhard Nocht Institut fur Tropenmedizin; German Center for Infection Research; Ruhr University Bochum; University of Bern; Ruhr University Bochum; Paul Ehrlich Institute; Helmholtz Association; Helmholtz-Center for Infection Research; Hannover Medical School; Hannover Medical School; Hannover Medical School; Heinrich Heine University Dusseldorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; Leibniz Association; Bernhard Nocht Institut fur Tropenmedizin; University of Bern; Ruhr University Bochum; St. Marien Hospital; Ruhr University Bochum; St. Marien Hospital; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; German Center for Infection Research; University of Lubeck
  摘要：Mycophenolic acid (MPA) is commonly used in immunosuppressive regimens following solid organ transplantation. We demonstrate that MPA treatment reproducibly inhibits the replication of a range of viruses, including severe respiratory syndrome coronavirus 2 (SARS-CoV-2). Mechanistically, we identified cellular guanosine triphosphate pool depletion as a key mediator of this antiviral effect. Strikingly, this inhibition can be overcome which was correlated with the emergence of three breakthrough...
• GSK3β phosphorylated tau filaments are probably not like those from AD brains AI翻译
  作者：Scheres, Sjors H. W.
  作者单位：MRC Laboratory Molecular Biology
• Acyl-CoA-binding protein as a driver of pathological aging AI翻译
  作者：Montegut, Lea; Lambertucci, Flavia; Moledo-Nodar, Lucas; Fiuza-Luces, Carmen; Rodriguez-Lopez, Carlos; Serra-Rexach, Jose Antonio; Lachkar, Sylvie; Motino, Omar; Abdellatif, Mahmoud; Durand, Sylvere; Aprahamian, Fanny; Carbonnier, Vincent; Le Corre, Delphine; Richard, Sophie Mouillet-; Chen, Hui; Sauvat, Allan; Dong, Yanbing; Li, Sijing; Rong, Yan; Pietrocola, Federico; Puig, Pierre Laurent-; Lopez-Otin, Carlos; Martins, Isabelle; Barcena, Clea; Lucia, Alejandro; Kroemer, Guido
  作者单位：Universite Paris Cite; Institut Universitaire de France; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; UNICANCER; Gustave Roussy; University of Oviedo; Instituto de Salud Carlos III; General University Gregorio Maranon Hospital; Complutense University of Madrid; Universidad de Valladolid; Medical University of Graz; Institut Universitaire de France; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Karolinska Institutet; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Europeen Georges-Pompidou - APHP; Universidad Antonio de Nebrija; European University of Madrid; Icahn School of Medicine at Mount Sinai
  摘要：The tissue hormone acyl coenzyme A-binding protein (ACBP, encoded by the gene diazepam-binding inhibitor, DBI) has been implicated in various facets of pathological aging. Here, we show that ACBP plasma concentrations are elevated in (close-to-)centenarians (mean +/- SD age 99.5 +/- 4.5 y) commensurate with their health deterioration, correlating with a reduced glomerular filtration rate and a surge in senescence-associated cytokines. ACBP neutralization by means of a monoclonal antibody (mAb)...
• SARS- CoV-2 infection induces ZBP1-dependent PANoptosis in bystander cells AI翻译
  作者：Yang, Bo; Hu, Ao; Wang, Tiantian; Chen, Xiaolin; Ma, Caina; Yang, Xinyue; Deng, Kai
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
  摘要：Virus-induced excessive inflammatory response is a key contributor to pathology in respiratory viral infections. However, the underlying mechanisms by which viral infection provokes intense inflammatory reaction and how sustained inflammation leads to tissue damage are not fully understood. Using severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as an example, our research demonstrates that SARS-CoV-2 infection can induce PANoptosis in bystander cells, contributing to the ...
• Ancient forests help document the long-term impacts of climate change AI翻译
  作者：Anderson, David G.
  作者单位：University of Tennessee System; University of Tennessee Knoxville