28期

最新文章

• CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors AI翻译
  作者：Horwitz, Elad; Dubash, Taronish D.; Szabolcs, Annamaria; Wittner, Ben S.; Kreuzer, Johannes; Morris, Robert; Bardia, Aditya; Chirn, Brian; Wiley, Devon; Che, Dante; Russell, Hunter C.; Lopez, Xcanda Ixchel Herrera; Fox, Douglas B.; Antmen, Ezgi; Burr, Risa; Ting, David T.; Haas, Wilhelm; Sade-Feldman, Moshe; Maheswaran, Shyamala; Haber, Daniel A.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School
  摘要：The mitotic inhibitor docetaxel (DTX) is often used to treat endocrine-refractory metastatic breast cancer, but initial responses are mitigated as patients develop disease progression. Using a cohort of ex vivo cultured circulating tumor cells (CTCs) from patients with heavily pretreated breast cancer (n=18), we find distinct patterns of response to DTX, which are intrinsic and independent of past clinical treatment with taxanes. In some CTC cultures, treatment with a single dose of DTX result...
• Noncanonical action of circadian clock genes controls winter diapause entry via the NuA4/TIP60 complex in Harmonia axyridis AI翻译
  作者：Gao, Qiao; Dai, Yi-Fei; Zhao, Yu-Lian; Li, Xue; An, Hao-Min; King-Jones, Kirst; Wang, Jia-Lu; Wang, Xiao-Ping; Liu, Wen
  作者单位：Huazhong Agricultural University; University of Alberta
  摘要：To adapt to seasonal changes, many animals, particularly insects, enter a dormancy-like condition known as diapause, which is primarily accomplished by sensing photoperiodic signals. The circadian clock, which is driven by positive regulators Clock (CLK) and Cycle (CYC), and negative regulators Period and Timeless, is thought to mediate this response. However, it remains unclear whether diapause induction involves a canonical rhythmic mechanism or occurs independently of their traditional role...
• Autophagic stress activates distinct compensatory secretory pathways in neurons AI翻译
  作者：Palumbos, Sierra D.; Popolow, Jacob; Goldsmith, Juliet; Holzbaur, Erika L. F.
  作者单位：University of Pennsylvania
  摘要：Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and aggregated proteins. However, the late onset of diseases suggests that compensatory quality control mechanisms may be engaged to delay these deleterious effects. Neurons expressing common familial Parkinson's disease-associated mutations in the leucine-rich repeat kinase 2 (LRRK2) exhibit defective autophagy. Here, we demonstrate that both primary murine n...
• BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza AI翻译
  作者：Soni, Sourabh; Yildiz, Soner; Allen, Emma Kaitlynn; Petersen, Hans; Peeples, Mark; El Zahed, Sara; Rosas, Lorena; Anang, Vandana; Antonescu, Laura; Nho, Richard Seonghun; Mora, Ana Lucia; Horowitz, Jeffrey Craig; Rojas, Mauricio; Medina, Rafael Andres; Thomas, Paul Glyndwr; Garcia-Sastre, Adolfo; Tesfaigzi, Yohannes; Mebratu, Yohannes Afework
  作者单位：University System of Ohio; Ohio State University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; St Jude Children's Research Hospital; Lovelace Respiratory Research Institute; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; Research Institute at Nationwide Children's Hospital; Center for Vaccines & Immunity; Emory University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital
  摘要：Influenza A viruses (IAVs) pose a significant public health threat, with host factors playing a crucial role in disease severity. We investigated the role of Bcl-2-interacting killer (BIK) in IAV infection using cellular and mouse models, and influenza-infected human cohort. In airway epithelial cells (AECs), BIK deficiency impaired viral replication, while BIK restoration enhanced it. Conversely, airway-specific BIK overexpression in mice increased viral load, inflammation, and mortality, whe...
• Electrochemically controlled switching of dyes for enhanced superresolution optical fluctuation imaging (EC-SOFI) AI翻译
  作者：Yang, Ying; Ma, Yuanqing; Tilley, Richard D.; Gooding, J. Justin
  作者单位：University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; European Molecular Biology Laboratory (EMBL); University of New South Wales Sydney
  摘要：In superresolution optical fluctuation imaging (SOFI), molecules spaced closer than the diffraction limit can be separated through spatial and temporal correlation analysis of the fluorescence intensity fluctuations. The resolution and speed of SOFI imaging greatly depend on the characteristics of these fluorescence fluctuations. Fluorophores with stochastic and rapid fluorescence fluctuations are favorable for improving SOFI imaging resolution and speed, especially in high-order cumulant anal...
• Human milk IgA promotes normal immune development by limiting Th17-inducing Erysipelatoclostridium ramosum in the infant gut AI翻译
  作者：Donald, Katherine; Serapio-Palacios, Antonio; Bozorgmehr, Tahereh; Ma, Mandi; Garcia, Ma Andrea Isabelle; Petersen, Charisse; Mandhane, Piushkumar; Subbarao, Padmaja; Moraes, Theo J.; Simons, Elinor; Turvey, Stuart; Azad, Meghan B.; Finlay, B. Brett
  作者单位：University of British Columbia; University of British Columbia; University of California System; University of California Davis; University of British Columbia; BC Children's Hospital; University of Alberta; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; McMaster University; University of Manitoba; University of Manitoba; University of Manitoba; Children's Hospital Research Institute of Manitoba; University of Manitoba; University of British Columbia
  摘要：The gut microbiota is highly dynamic during the first year of life and plays a crucial role in immune development. Breastfeeding is known to support infant health, but the contributions of the numerous breastmilk components to gut microbiota and immune maturation remain unclear. Secretory IgA (SIgA), the most abundant antibody in human milk, is a key modulator of gut microbiota composition. We have shown previously that mouse milk SIgA protects against asthma by limiting segmented filamentous ...
• Structure-based discovery of positive allosteric modulators of the A1 adenosine receptor AI翻译
  作者：Nguyen, Anh T. N.; Panel, Nicolas; Vo, Duc Duy; Thai, Bui San; Chia, Ling Yeong; Lu, Cam Sinh; Hellyer, Shane D.; Langiu, Monica; Jorg, Manuela; Gregory, Karen J.; Kihlberg, Jan; White, Paul J.; Scammells, Peter J.; Christopoulos, Arthur; Carlsson, Jens; May, Lauren T.
  作者单位：Monash University; Uppsala University; Uppsala University; Monash University; Monash University
  摘要：Allosteric modulation of G protein-coupled receptors (GPCRs) is an exciting strategy for developing new therapeutic agents, and it has several advantages over more commonly used orthosteric drugs. Recently determined GPCR structures have revealed allosteric pockets facing the lipid bilayer, enabling rational drug design. Here, we develop a virtual screening strategy to discover ligands of extrahelical binding pockets and apply this approach to the adenosine A1 receptor (A1R). The A1R is a high...
• Orientation fields predict human perception of 3D shape from shading AI翻译
  作者：Aubuchon, Celine; Vergne, Romain; Cholewiak, Steven A.; Kunsberg, Benjamin; Holtmann-Rice, Daniel; Zucker, Steven W.; Fleming, Roland W.
  作者单位：Justus Liebig University Giessen; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Alphabet Inc.; Google Incorporated; Yale University; Amazon.com; Alphabet Inc.; Google Incorporated
  摘要：How the brain recovers the three- dimensional structure of surfaces and objects from 2D retinal images remains mysterious. Shading patterns provide one of the most powerful-yet least understood-visual depth cues. Most theories assume the brain infers surface normals from luminance values. However, this seems unlikely as visual neurons are broadly insensitive to luminance. To identify alternative cues, we measured responses of model orientation- selective cell populations to images of shaded ob...
• Chlorophyll trends are negative for lakes but positive for estuarine-coastal waters AI翻译
  作者：Cloern, James E.; Jassby, Alan D.
  作者单位：United States Department of the Interior; United States Geological Survey; University of California System; University of California Davis
  摘要：Nutrient (nitrogen and phosphorus) pollution is an environmental problem of global concern because overenrichment of water bodies increases phytoplankton biomass and ecosystem metabolism, depletes oxygen in bottom waters, and increases the frequency and intensity of harmful algal blooms. These responses to nutrient pollution have motivated policies to reduce anthropogenic nutrient inputs. However, these policies have not been universally implemented and their success at reducing phytoplankton ...