2024

最新文章

• The ISR downstream target ATF4 represses long- term memory in a cell type-specific manner AI翻译
  作者：Mahmood, Niaz; Choi, Jung- Hyun; Wu, Pei You; Dooling, Sean W.; Watkins, Trent A.; Huang, Ziying; Lipman, Jesse; Zhao, Hanjie; Yang, Anqi; Silversmith, Jake; Inglebert, Yanis; Koumenis, Constantinos; Sharma, Vijendra; Lacaille, Jean- Claude; Sossin, Wayne S.; Khoutorsky, Arkady; Mckinney, R. Anne; Costa-Mattioli, Mauro; Sonenberg, Nahum
  作者单位：McGill University; McGill University; McGill University; Baylor College of Medicine; Universite de Montreal; University of Pennsylvania; University of Windsor; McGill University; McGill University; McGill University; McGill University; Baylor College of Medicine
  摘要：The integrated stress response (ISR), a pivotal protein homeostasis network, plays a critical role in the formation of long- term memory (LTM). The precise mechanism by which the ISR controls LTM is not well understood. Here, we report insights into how the ISR modulates the mnemonic process by using targeted deletion of the activating transcription factor 4 (ATF4), found that the removal of ATF4 from forebrain excitatory neurons (but not from inhibitory neurons, cholinergic neurons, or astroc...
• Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells AI翻译
  作者：Morino-Koga, Saori; Tsuruda, Mariko; Zhao, Xueyu; Oshiro, Shogo; Yokomizo, Tomomasa; Yamane, Mariko; Tanigawa, Shunsuke; Miike, Koichiro; Usuki, Shingo; Yasunaga, Kei - ichiro; Nishinakamura, Ryuichi; Suda, Toshio; Ogawa, Minetaro
  作者单位：Kumamoto University; Kumamoto University; Tokyo Women's Medical University; Kumamoto University; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); RIKEN; Kumamoto University; Kumamoto University
  摘要：in vivo during mouse embryogenesis. When cultured in vitro, cells from the embryo phenotypically defined as pre-HSC-I and pre-HSC-II have the potential to differentiate into HSCs. However, minimal factors required for HSC induction from HECs have not yet been determined. In this study, we demonstrated that stem cell factor 11.5 pre-HSC-I in a serum-free and feeder-free culture condition. In contrast, E10.5 pre-HSC-I and HECs required an endothelial cell layer in addition to SCF and TPO to diff...
• Enhancement of the anomalous Hall effect by distorting the Kagome lattice in an antiferromagnetic material AI翻译
  作者：Roychowdhury, Subhajit; Samanta, Kartik; Singh, Sukriti; Schnelle, Walter; Zhang, Yang; Noky, Jonathan; Vergniory, Maia G.; Shekhar, Chandra; Felser, Claudia
  作者单位：Max Planck Society; Indian Institute of Science Education & Research (IISER) - Bhopal; University of Tennessee System; University of Tennessee Knoxville; University of Tennessee System; University of Tennessee Knoxville
  摘要：In topological magnetic materials, the topology of the electronic wave function is strongly coupled to the structure of the magnetic order. In general, ferromagnetic Weyl semimetals generate a strong anomalous Hall conductivity (AHC) due to a large Berry curvature that scales with their magnetization. In contrast, a comparatively small AHC is observed in noncollinear antiferromagnets. We investigated HoAgGe, an antiferromagnetic (AFM) Kagome spin-ice compound, which crystallizes in a hexagonal...
• Unique stick-slip crack dynamics of double- network hydrogels under pure- shear loading AI翻译
  作者：Zheng, Yong; Wang, Yiru; Tian, Fucheng; Nakajima, Tasuku; Hui, Chung-Yuen; Gong, Jian Ping
  作者单位：Hokkaido University; Hokkaido University; Hokkaido University; Cornell University; Hokkaido University; Zhejiang University
  摘要：In this work, we have found that a prenotched double- network (DN) hydrogel, when subjected to tensile loading in a pure- shear geometry, exhibits intriguing stick-slip crack dynamics. These dynamics synchronize with the oscillation of the damage (yielding) zone at the crack tip. Through manipulation of the loading rate and the predamage level of the brittle network in DN gels, we have clarified that this phenomenon stems from the significant amount of energy dissipation required to form the d...
• It matters what you see: Graphic media images of war and terror may amplify distress AI翻译
  作者：Holman, Alison; Garfin, Dana Rose; Silver, Roxane Cohen
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Los Angeles; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：Media exposure to graphic images of violence has proliferated in contemporary society, particularly with the advent of social media. Extensive exposure to media coverage immediately after the 9/11 attacks and the Boston Marathon bombings (BMB) was associated with more early traumatic stress symptoms; in fact, several hours of BMB- related daily media exposure was a stronger correlate of distress than being directly exposed to the bombings themselves. Researchers have replicated these findings ...
• Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles AI翻译
  作者：Park, Daehun; Fujise, Kenshiro; Wu, Yumei; Lujan, Rafael; Del Olmo-Cabrera, Sergio; Wesseling, John F.; De Camilli, Pietro
  作者单位：Yale University; Yale University; Yale University; Catholic University of Korea; Catholic University of Korea; Universidad de Castilla-La Mancha; Universidad Miguel Hernandez de Elche
  摘要：Members of the synaptophysin and synaptogyrin family are vesicle proteins with four transmembrane domains. In spite of their abundance in synaptic vesicle (SV) membranes, their role remains elusive and only mild defects at the cellular and organismal level are observed in mice lacking one or more family members. Here, we show that coexpression with synapsin in fibroblasts of each of the four brain-- enriched members of this family-synaptophysin, synaptoporin, synaptogyrin 1, and synaptogyrin 3...
• MiR-155-targeted IcosL controls tumor rejection AI翻译
  作者：Tili, Esmerina; Otsu, Hajime; Commisso, Teresa L.; Palamarchuk, Alexey; Balatti, Veronica; Michaille, Jean-Jacques; Nuovo, Gerard James; Croce, Carlo M.
  作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute
  摘要：Elevated levels of miR-155- 155 in solid and liquid malignancies correlate with aggressiveness of the disease. In this manuscript, we show that miR-155- 155 targets transcripts encoding IcosL, the ligand for Inducible T- cell costimulator (Icos), thus impairing the ability of T cells to recognize and eliminate malignant cells. We specifically found that over- expression of miR-155- 155 in B cells of E mu- miR- 155 mice causes loss of IcosL expression as they progress toward malignancy. Similar...
• The m6A reader SlYTH2 negatively regulates tomato fruit aroma by impeding the translation process AI翻译
  作者：Bian, Hanxiao; Song, Peizhe; Gao, Ying; Deng, Zhiping; Huang, Chenyang; Yu, Lei; Wang, Hanqing; Ye, Bingbing; Cai, Zhihe; Pan, Yu; Wang, Fengqin; Liu, Jianzhao; Gao, Xiangwei; Chen, Kunsong; Jia, Guifang; Klee, Harry J.; Zhang, Bo
  作者单位：Universidade Federal de Minas Gerais; Chinese Academy of Sciences; Peking University; Chongqing University; Zhejiang Academy of Agricultural Sciences; Zhejiang University; Zhejiang University; Southwest University - China; Zhejiang University; Peking University; Peking University; Zhejiang University
  摘要：N 6- methyladenosine (m 6 A) is a fundamentally important RNA modification for gene regulation, whose function is achieved through m 6 A readers. However, whether and how m 6 A readers play regulatory roles during fruit ripening and quality formation remains unclear. Here, we characterized SlYTH2 as a tomato m 6 A reader protein and profiled the binding sites of SlYTH2 at the transcriptome- wide level. SlYTH2 undergoes liquid- liquid phase separation and promotes RNA-protein condensate formati...
• Flp/ FRT- mediated disruption of ptex150 and exp2 in Plasmodium falciparum sporozoites inhibits liver- stage development AI翻译
  作者：McConville, Robyn; Krol, Jelte M. M.; Steel, Ryan W. J.; O'Neill, Matthew T.; Davey, Bethany K.; Hodder, Anthony N.; Nebl, Thomas; Cowman, Alan F.; Kneteman, Norman; Boddey, Justin A.
  作者单位：Walter & Eliza Hall Institute; University of Melbourne; University of Alberta
  摘要：Plasmodium falciparum causes severe malaria and assembles a protein translocon (PTEX) complex at the parasitophorous vacuole membrane (PVM) of infected erythrocytes, through which several hundred proteins are exported to facilitate growth. The preceding liver stage of infection involves growth in a hepatocyte- derived PVM; however, the importance of protein export during P. falciparum liver infection remains unexplored. Here, we use the FlpL/ FRT system to conditionally excise genes in P. falc...
• An aggregated mitochondrial distribution in preimplantation embryos disrupts nuclear morphology, function, and developmental potential AI翻译
  作者：Lee, In-Won; Tazehkand, Abbas Pirpour; Sha, Zi-Yi; Adhikari, Deepak; Carroll, John
  作者单位：Monash University
  摘要：A dispersed cytoplasmic distribution of mitochondria is a hallmark of normal cellular organization. Here, we have utilized the expression of exogenous Trak2 in mouse oocytes and embryos to disrupt the dispersed distribution of mitochondria by driving them into a large cytoplasmic aggregate. Our findings reveal that aggregated mitochondria have minimal impact on asymmetric meiotic cell divisions of the oocyte. In contrast, aggregated mitochondria during the first mitotic division result in daug...