2024

最新文章

• Genomic structural variation contributes to evolved changes in gene expression in high- altitude Tibetan sheep AI翻译
  作者：Liang, Xiaolong; Duan, Qijiao; Li, Bowen; Wang, Yinjia; Bu, Yueting; Zhang, Yonglu; Kuang, Zhuoran; Mao, Leyan; An, Xuan; Wang, Huihua; Yang, Xiaojie; Wan, Na; Feng, Zhilong; Shen, Wei; Miao, Weilan; Chen, Jiaqi; Liu, Sanyuan; Storz, Jay F.; Liu, Jianquan; Nevo, Eviatar; Li, Kexin
  作者单位：Lanzhou University; Chinese Academy of Agricultural Sciences; Institute of Animal Science, CAAS; University of Nebraska System; University of Nebraska Lincoln; University of Haifa
  摘要：Tibetan sheep were introduced to the Qinghai Tibet plateau roughly 3,000 B.P., making this species a good model for investigating genetic mechanisms of high - altitude adaptation over a relatively short timescale. Here, we characterize genomic structural variants (SVs) that distinguish Tibetan sheep from closely related, low - altitude Hu sheep, and we examine associated changes in tissue - specific gene expression. We document differentiation between the two sheep breeds in frequencies of SVs...
• Frost- free zone on leaves revisited AI翻译
  作者：Einbock, Annika; Conen, Franz
  作者单位：University of Basel
  摘要：Particular frost patterns on natural leaves had prompted Yao et al. [Y. Yao et al ., Proc. Natl. Acad. Sci. U.S.A. 117 , 6323-6329 (2020)] to investigate the underlying physics. Their work revealed why on corrugated surfaces ice forms on crests and dries out adjacent grooves. In the absence of frost, in contrast, grooves tend to constitute niches on a leaf where microorganisms are less limited by moisture than in other locations. Here, we show that microorganisms able to nucleate ice before it...
• Peripheral positions encode transport specificity in the small multidrug resistance exporters AI翻译
  作者：Burata, Olive E.; O'Donnell, Ever; Hyun, Jeonghoon; Lucero, Rachael M.; Thomas, Junius E.; Gibbs, Ethan M.; Reacher, Isabella; Carney, Nolan A.; Stockbridge, Randy B.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：In secondary active transporters, a relatively limited set of protein folds have evolved diverse solute transport functions. Because of the conformational changes inherent to transport, altering substrate specificity typically involves remodeling the entire structural landscape, limiting our understanding of how novel substrate specificities evolve. In the current work, we examine a structurally minimalist family of model transport proteins, the small multidrug resistance (SMR) transporters, t...
• Progesterone inactivation in decidual stromal cells: A mechanism for inflammation- induced parturition AI翻译
  作者：Detomaso, Angela; Kim, Hyeyon; Shauh, Jacqueline; Adulla, Anika; Zigo, Sarah; Ghoul, Maya; Presicce, Pietro; Kallapur, Suhas G.; Goodman, Wendy; Tilburgs, Tamara; Way, Sing-Sing; Hackney, David; Moore, John; Mesiano, Sam
  作者单位：University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University Hospitals of Cleveland; University System of Ohio; Case Western Reserve University
  摘要：The process of human parturition involves inflammation at the interface where fetal chorion trophoblast cells interact with maternal decidual stromal (DS) cells and maternal immune cells in the decidua (endometrium of pregnancy). This study tested the hypothesis that inflammation at the chorion-decidua interface (CDI) induces labor by negating the capacity for progesterone (P4) to block labor and that this is mediated by inactivation of P4 in DS cells by aldo - keto reductase family 1 member C...
• A highly reproducible and efficient method for retinal organoid differentiation from human pluripotent stem cells AI翻译
  作者：Harkin, Jade; Pena, Kiersten H.; Gomes, Catia; Hernandez, Melody; Lavekar, Sailee S.; So, Kaman; Lentsch, Kelly; Feder, Elyse M.; Morrow, Sarah; Huang, Kang - Chieh; Tutrow, Kaylee D.; Morris, Ann; Zhang, Chi; Meyer, Jason S.
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Indianapolis; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of Kentucky; Indiana University System; Indiana University Indianapolis
  摘要：Human pluripotent stem cell (hPSC) - derived retinal organoids are three - dimensional cellular aggregates that differentiate and self - organize to closely mimic the spatial and temporal patterning of the developing human retina. Retinal organoid models serve as reliable tools for studying human retinogenesis, yet limitations in the efficiency and reproducibility of current retinal organoid differentiation protocols have reduced the use of these models for more high - throughput applications ...
• Cetaceans are the next frontier for vocal rhythm research AI翻译
  作者：Hersh, Taylor A.; Ravignani, Andrea; Whitehead, Hal
  作者单位：Oregon State University; Max Planck Society; Dalhousie University; Sapienza University Rome
  摘要：While rhythm can facilitate and enhance many aspects of behavior, its evolutionary trajectory in vocal communication systems remains enigmatic. We can trace evolutionary processes by investigating rhythmic abilities in different species, but research to date has largely focused on songbirds and primates. We present evidence that cetaceans-whales, dolphins, and porpoises-are a missing piece of the puzzle for understanding why rhythm evolved in vocal communication systems. Cetaceans not only pro...
• Inhibition of a cyclic nucleotide- gated channel on neuronal cilia activates unfolded protein response in intestinal cells to promote longevity AI翻译
  作者：Li, Dongdong; Chen, Di; Li, Wei; Ou, Guangshuo
  作者单位：Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Zhejiang University; Tsinghua University
  摘要：Ciliary defects are linked to ciliopathies, but impairments in the sensory cilia of Caenorhabditis elegans neurons extend lifespan, a phenomenon with previously unclear mechanisms. Our study reveals that neuronal cilia defects trigger the unfolded protein response of the endoplasmic reticulum (UPR ER ) within intestinal cells, a process dependent on the insulin/insulin - like growth factor 1 (IGF - 1) signaling transcription factor and the release of neuronal signaling molecules. While inhibit...
• N6-methyladenosine modification of a parvovirus-encoded small noncoding RNA facilitates viral DNA replication through recruiting Y- family DNA polymerases AI翻译
  作者：Ning, Kang; Zhao, Junxing; Feng, Zehua; Park, Soo Yeun; Mcfarlin, Shane; Cheng, Fang; Yan, Ziying; Wang, Jingxin; Qiu, Jianming
  作者单位：University of Kansas; University of Kansas Medical Center; University of Kansas; University of Chicago; University of Iowa
  摘要：Human bocavirus 1 (HBoV1) is a human parvovirus that causes lower respiratory tract infections in young children. It contains a single-stranded (ss) DNA genome of similar to 5.5 kb that encodes a small noncoding RNA of 140 nucleotides known as bocavirus-encoded small RNA (BocaSR), in addition to viral proteins. Here, we determined the secondary structure of BocaSR in vivo by using DMS-MaPseq. Our findings reveal that BocaSR undergoes N6-methyladenosine (m6A) modification at multiple sites, whi...
• The spillover effect of mandatory renewable portfolio standards AI翻译
  作者：Zhou, Shan; Solomon, Barry D.; Brown, Marilyn A.
  作者单位：Purdue University System; Purdue University; Michigan Technological University; University System of Georgia; Georgia Institute of Technology
  摘要：Renewable Portfolio Standards (RPSs) are one of the most prevalent and impactful clean energy policies implemented by states in the United States. This paper investigates the regional spillover effect of RPS policies using a directed dyad panel dataset of renewable electricity generation in US states from 1991 to 2021. Regional spillover effect is measured in two ways: by considering the influence of an RPS enacted in neighboring states and in states in the same regional transmission organizat...
• The red alga Porphyridium as a host for molecular farming: Efficient production of immunologically active hepatitis C virus glycoprotein AI翻译
  作者：Hammel, Alexander; Cucos, Lia-Maria; Caras, Iuliana; Ionescu, Irina; Tucureanu, Catalin; Tofan, Vlad; Costache, Adriana; Onu, Adrian; Hoepfner, Lara; Hippler, Michael; Neupert, Juliane; Popescu, Costin-Ioan; Stavaru, Crina; Branza-Nichita, Norica; Bock, Ralph
  作者单位：Max Planck Society; Romanian Academy; Institute of Biochemistry, Bucharest; University of Munster; Okayama University; Norwegian Institute of Bioeconomy Research
  摘要：Microalgae are promising production platforms for the cost- effective production of recombinant proteins. We have recently established that the red alga Porphyridium purpureum provides superior transgene expression properties, due to the episomal maintenance of transformation vectors as multicopy plasmids in the nucleus. Here, we have explored the potential of Porphyridium to synthesize complex pharmaceutical proteins to high levels. Testing expression constructs for a candidate subunit vaccin...