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作者：Hernandez-Garcia, Jorge; Serrano-Mislata, Antonio; Lozano-Quiles, Maria; Urbez, Cristina; Nohales, Maria A.; Blanco-Tourinan, Noel; Peng, Huadong; Ledesma-Amaro, Rodrigo; Blazquez, Miguel A.
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universitat Politecnica de Valencia; CSIC-UPV - Instituto de Biologia Molecular y Celular de Plantas (IBMCP); Wageningen University & Research; Imperial College London; Imperial College London
摘要：DELLA proteins are negative regulators of the gibberellin response pathway in angiosperms, acting as central hubs that interact with hundreds of transcription factors (TFs) and regulators to modulate their activities. While the mechanism of TF sequestration by DELLAs to prevent DNA binding to downstream targets has been extensively documented, the mechanism that allows them to act as coactivators remains to be understood. Here, we demonstrate that DELLAs directly recruit the Mediator complex t...
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作者：Lavanchy, Eleonore; Weir, Bruce S.; Goudet, Jerome
作者单位：University of Lausanne; Swiss Institute of Bioinformatics; University of Lausanne; University of Washington; University of Washington Seattle
摘要：Measuring inbreeding and its consequences on fitness is central for many areas in biology including human genetics and the conservation of endangered species. However, there is no consensus on the best method, neither for quantification of inbreeding itself nor for the model to estimate its effect on specific traits. We simulated traits based on simulated genomes from a large pedigree and empirical whole-genome sequences of human data from populations with various sizes and structures (from th...
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作者：Pollack, Dan; Nozoe, Takashi; Kussell, Edo
作者单位：New York University; University of Tokyo; University of Tokyo; University of Tokyo; New York University
摘要：Proteins that are kinetically stable are thought to be less prone to both aggregation and proteolysis. We demonstrate that the classical lac system of Escherichia coli can be leveraged as a model system to study this relation. beta- galactosidase (LacZ) plays a critical role in lactose metabolism and is an extremely stable protein that can persist in growing cells for multiple generations after expression has stopped. By attaching degradation tags to the LacZ protein, we find that LacZ can be ...
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作者：Schnell, Eric; Muthukrishna, Michael
作者单位：University of London; London School Economics & Political Science
摘要：Previous models suggest that indirect reciprocity (reputation) can stabilize large - scale human cooperation [K. Panchanathan, R. Boyd, Nature 432 , 499-502 (2004)]. The logic behind these models and experiments [J. Gross et al. , Sci. Adv. 9, eadd8289 (2023) and O. P. Hauser, A. Hendriks, D. G. Rand, M. A. Nowak, Sci. Rep. 6, 36079 (2016)] is that a strategy in which individuals conditionally aid others based on their reputation for engaging in costly cooperative behavior serves as a punishme...
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作者：Mondal, Dipon K.; Xie, Christopher; Pascal, Gabriel J.; Buraschi, Simone; Iozzo, Renato V.
作者单位：Thomas Jefferson University; Thomas Jefferson University
摘要：The complex interplay between malignant cells and the cellular and molecular components of the tumor stroma is a key aspect of cancer growth and development. These tumor- host interactions are often affected by soluble bioactive molecules such as proteoglycans. Decorin, an archetypical small leucine - rich proteoglycan primarily expressed by stromal cells, affects cancer growth in its soluble form by interacting with several receptor tyrosine kinases (RTK). Overall, decorin leads to a context ...
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作者：Chen, Junliang; Zhang, Fangzhou; Kuang, Min; Wang, Li; Wang, Huaping; Li, Wei; Yang, Jianping
作者单位：Donghua University; Fudan University; Fudan University
摘要：Recently, there has been a notable surge in interest regarding reclaiming valuable chemicals from waste plastics. However, the energy - intensive conventional thermal catalysis does not align with the concept of sustainable development. Herein, we report a sustainable electrocatalytic approach allowing the selective synthesis of glycolic acid (GA) from waste polyethylene terephthalate (PET) over a Pd 67 Ag 33 alloy catalyst under ambient conditions. Notably, Pd 67 Ag 33 delivers a high mass ac...
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作者：Espinoza, Baltazar; Adiga, Aniruddha; Warren, Andrew Scott; Venkatramanan, Srinivasan; Chen, Jiangzhuo; Lewis, Bryan Leroy; Vullikanti, Anil; Barrett, Christopher Louis; Athreya, Siva; Sundaresan, Rajesh; Chandru, Vijay; Laxminarayan, Ramanan; Schaffer, Benjamin; Vincent Poor, H.; Levin, Simon A.; V. Marathe, Madhav
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作者：Rakhmani, Inaya; Yusuf, Arief Anshory; Saleh, Hasnawati; Sakhiyya, Zulfa; Pertiwi, Kanti; Nasir, Sudirman; Wiratraman, Herlambang P.; Juliandi, Berry; Nugroho, Yanuar; Jompa, Jamaluddin
作者单位：University of Indonesia; University of Indonesia; Universitas Padjadjaran; Universitas Hasanuddin; Universitas Negeri Semarang; University of Melbourne; Gadjah Mada University; University of Manchester; Universitas Hasanuddin
摘要：In the past three decades, there has been a rise in young academy movements in the Global North and South. Such movements, in at least Germany and the Netherlands, have been shown to be quite effective in connecting scientific work with society. Likewise, these movements share a common goal of developing interdisciplinary collaboration among young scientists, which contributes to the growth of a nation's-but also global-scientific endeavors. This paper focuses on the young academy movement in ...
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作者：Vigano, Simone; Bayramova, Rena; Doeller, Christian F.; Bottini, Roberto
作者单位：Max Planck Society; University of Trento; Max Planck Society; Norwegian University of Science & Technology (NTNU)
摘要：Functional neuroimaging studies indicate that the human brain can represent concepts and their relational structure in memory using coding schemes typical of spatial navigation. However, whether we can read out the internal representational geometries of conceptual spaces solely from human behavior remains unclear. Here, we report that the relational structure between concepts in memory might be reflected in spontaneous eye movements during verbal fluency tasks: When we asked participants to r...
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作者：Wagner, Robert J.; Lamont, Samuel C.; White, Zachary T.; Vernerey, Franck J.
作者单位：Cornell University; University of Colorado System; University of Colorado Boulder
摘要：Dynamic networks composed of constituents that break and reform bonds reversibly are ubiquitous in nature owing to their modular architectures that enable functions like energy dissipation, self-healing, and even activity. While bond breaking depends only on the current configuration of attachment in these networks, reattachment depends also on the proximity of constituents. Therefore, dynamic networks composed of macroscale constituents (not benefited by the secondary interactions cohering an...
