2024

最新文章

• Maternal genetic variants in kinesin motor domains prematurely increase egg aneuploidy AI翻译
  作者：Biswas, Leelabati; Tyc, Katarzyna M.; Aboelenain, Mansour; Sun, Siqi; Dundovic, Iva; Vukusic, Kruno; Liu, Jason; Guo, Vanessa; Xu, Min; Scott, Richard T.; Tao, Xin; Tolic, Iva M.; Xing, Jinchuan; Schindler, Karen
  作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Egyptian Knowledge Bank (EKB); Mansoura University; Rudjer Boskovic Institute; Rutgers University System; Rutgers University New Brunswick
  摘要：The female reproductive lifespan is highly dependent on egg quality, especially the presence of a normal number of chromosomes in an egg, known as euploidy. Mistakes in meiosis leading to egg aneuploidy are frequent in humans. Yet, knowledge of the precise genetic landscape that causes egg aneuploidy in women is limited, as phenotypic data on the frequency of human egg aneuploidy are difficult to obtain and therefore absent in public genetic datasets. Here, we identify genetic determinants of ...
• What are fair prior odds of guilt in criminal cases? AI翻译
  作者：Carriquiry, Alicia; Ommen, Danica M.
  作者单位：Iowa State University
• Incorrect statistical reasoning in Guyll et al. leads to biased claims about strength of forensic evidence AI翻译
  作者：Rosenblum, Michael; Chin, Elizabeth T.; Ogburn, Elizabeth L.; Nishimura, Akihiko; Westreich, Daniel; Datta, Abhirup; Vanderplas, Susan; Cuellar, Maria; Thompson, William C.
  作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Nebraska System; University of Nebraska Lincoln; University of Pennsylvania; University of Pennsylvania; University of California System; University of California Irvine
• Observed carbon decoupling of subnational production insufficient for net- zero goal by 2050 AI翻译
  作者：Zioga, Maria; Kotz, Maximilian; Levermann, Anders
  作者单位：Potsdam Institut fur Klimafolgenforschung; University of Potsdam; Humboldt University of Berlin
  摘要：Historically, economic growth has been closely coupled to carbon emissions responsible for climate change, but to stabilize global mean temperature, net- zero carbon emissions are necessary. Some economies have begun to reduce emissions while continuing to grow, but this decoupling is not fast enough to achieve global climate targets. Subnational climate actions seem to be crucial for the achievement of these targets. Here, we uncover the effectiveness of subnational efforts by estimating deco...
• A myeloid differentiation-like protein in partnership with Toll5 from the pest insect Spodoptera litura senses baculovirus infection AI翻译
  作者：Zhang, Ruonan; Zhong, Jielai; Li, Yanjun; Li, Mengge; Zhang, Jie; Hu, Qihao; Wen, Liang; Xu, Xiaoxia; Jin, Fengliang; Yang, Wanying; Lu, Yuzhen; Strand, Michael R.; Yu, Xiao-Qiang
  作者单位：South China Normal University; South China Agricultural University; South China Agricultural University; University System of Georgia; University of Georgia
  摘要：Many types of viruses infect insects and other arthropods. In contrast, little is known about how arthropods sense viruses, although several innate immune pathways including Toll have antiviral functions. Large DNA viruses in the family Baculoviridae are used to control a number of pest insects. Here, we studied Spodoptera litura and Autographa californica multiple nucleopolyhedrovirus (AcMNPV) to test the hypothesis that one or more myeloid differentiation-like (ML) proteins and Toll family m...
• Unraveling abiotic organic synthesis pathways in the mafic crust of mid- ocean ridges AI翻译
  作者：Nan, Jingbo; Peng, Xiaotong; Plumper, Oliver; ten Have, Iris C.; Lu, Jing- Guang; Liu, Qian-Bao; Li, Shao-Lin; Hu, Yingjie; Liu, Yu; Shen, Zhen; Yao, Weiqi; Tao, Renbiao; Preiner, Martina; Luo, Yongxiang
  作者单位：Chinese Academy of Sciences; Institute of Deep-Sea Science & Engineering, CAS; Chinese Academy of Sciences; Utrecht University; Utrecht University; Macau University of Science & Technology; Macau University of Science & Technology; Nanjing Xiaozhuang University; China University of Mining & Technology; Southern University of Science & Technology; Max Planck Society; Philipps University Marburg; Max Planck Society
  摘要：The aqueous alteration of the oceanic lithosphere provides significant energy that impacts the synthesis and diversity of organic compounds, which are crucial for the deep carbon cycle and may have provided the first building blocks for life. Although abiotic organic synthesis has been documented in mantle- derived rocks, the formation mechanisms and complexity of organic compounds in crustal rocks remain largely unknown. Here, we show the specific association of aliphatic carbonaceous matter ...
• Tipping the balance between fairness and efficiency through temporoparietal stimulation AI翻译
  作者：Soutschek, Alexander; Sahin, Tuerkay; Tobler, Philippe N.
  作者单位：University of Munich; University of Zurich
  摘要：Maximizing the welfare of society requires distributing goods between groups of people with different preferences. Such decisions are difficult because different moral principles impose irreconcilable solutions. For example, utilitarian efficiency (maximize overall outcome across individuals) may need trade- off against Rawlsian fairness norms (maximize the outcome for the worst- off individual). We identify a brain mechanism enabling decision- makers to solve such trade- offs between efficien...
• Four decades of Eukaryotic DNA replication: From yeast genetics to high- resolution cryo- EM structures of the replisome AI翻译
  作者：Tye, Bik-Kwoon
  作者单位：Cornell University
  摘要：I had my eyes set on DNA replication research when I took my first molecular biology course in graduate school. My election to the National Academy of Sciences came just when I was retiring from active research. It gives me an opportunity to reflect on my personal journey in eukaryotic DNA replication research, which started as a thought experiment and culminated in witnessing the determination of the cryoelectron microscopic structure of the yeast replisome in the act of transferring histone-...
• The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof- of- principle report AI翻译
  作者：Yamamoto, Erin A.; Bagley, Jacob H.; Geltzeiler, Mathew; Sanusi, Olabisi R.; Dogan, Aclan; Liu, Jesse J.; Piantino, Juan
  作者单位：Oregon Health & Science University; Oregon Health & Science University; Oregon Health & Science University
  摘要：The glymphatic pathway was described as a network of perivascular spaces (PVS) that facilitates the organized movement of cerebrospinal fluid (CSF) between the subarachnoid space and brain parenchyma ( 1 ). CSF mixes with interstitial fluid, promoting clearance of soluble by-products from the central nervous system. This is suspected to be impaired phatic studies in rodents showed CSF tracer flow through the subarachnoid space and from the subarachnoid space, providing early evidence for human...
• Dysregulated miR-124-3p in endometrial epithelial cells reduces endometrial receptivity by altering polarity and adhesion AI翻译
  作者：Zhou, Wei; Van Sinderen, Michelle; Rainczuk, Katarzyna; Menkhorst, Ellen; Sorby, Kelli; Osianlis, Tiki; Pangestu, Mulyoto; Santos, Leilani; Rombauts, Luk; Diez, Alberto Rosello -; Dimitriadis, Evdokia
  作者单位：University of Melbourne; The Royal Women's Hospital; Hudson Institute of Medical Research; Monash University; Monash University; Universitas Jenderal Soedirman; Monash University; Australian Regenerative Medicine Institute; University of Cambridge; University of Cambridge
  摘要：The endometrium undergoes substantial remodeling in each menstrual cycle to become receptive to an implanting embryo. Abnormal endometrial receptivity is one of the major causes of embryo implantation failure and infertility. MicroRNA- 124- 3p is elevated in both the serum and endometrial tissue of women with chronic endometritis, a condition associated with infertility. MicroRNA- 124- 3p also has a role in cell adhesion, a key function during receptivity to allow blastocysts to adhere and imp...