13期

最新文章

• Tetrapod species-area relationships across the Cretaceous-Paleogene mass extinction AI翻译
  作者：Close, Roger Adam; Reijenga, Bouwe Rutger
  作者单位：University of Oxford
  摘要：Mass extinctions are rare but catastrophic events that profoundly disrupt biodiversity. Widely accepted consequences of mass extinctions, such as biodiversity loss and the appearance of temporary disaster taxa, imply that species-area relationships (SARs, or how biodiversity scales with area) should change dramatically across these events: Specifically, both the slope (the rate of accumulation of new species with increasing area) and intercept (the density of species at local scales) of the po...
• Revealing the roles of the solid-electrolyte interphase in designing stable, fast- charging, low- temperature Li- ion batteries AI翻译
  作者：Tao, Lei; Zhang, Hanrui; Shah, Sameep Rajubhai; Yang, Xixian; Lai, Jianwei; Guo, Yanjun; Russell, Joshua A.; Xia, Dawei; Min, Jungki; Huang, Weibo; Shi, Chenguang; Liang, Zhaohui; Yu, Deyang; Hwang, Sooyeon; Xiong, Hui; Madsen, Louis A.; Zhao, Kejie; Shi, Feifei; Lin, Feng
  作者单位：Virginia Polytechnic Institute & State University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Purdue University System; Purdue University; Purdue University in Indianapolis; Boise State University; United States Department of Energy (DOE); Brookhaven National Laboratory; Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University
  摘要：Designing the solid-electrolyte interphase (SEI) is critical for stable, fast-charging, low-temperature Li-ion batteries. Fostering a fluorinated interphase, SEI enriched with LiF, has become a popular design strategy. Although LiF possesses low Li-ion conductivity, many studies have reported favorable battery performance with fluorinated SEIs. Such a contradiction suggests that optimizing SEI must extend beyond chemical composition design to consider spatial distributions of different chemica...
• Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens AI翻译
  作者：Tse, Megan W.; Zhu, Meilin; Peters, Benjamin; Hamami, Efrat; Chen, Julie; Davis, Kathleen P.; Nitz, Samuel; Weller, Juliane; Warrier, Thulasi; Hunt, Diana K.; Morales, Yoelkys; Kawate, Tomohiko; Gaulin, Jeffrey L.; Come, Jon H.; Hernandez-Bird, Juan; Huo, Wenwen; Neisewander, Isabelle; Yu, Xiao; Aceves-Salvador, Jose A.; Kiessling, Laura L.; Hung, Deborah T.; Mecsas, Joan; Aldridge, Bree B.; Isberg, Ralph R.; Blainey, Paul C.
  作者单位：Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Tufts University; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Tufts University
  摘要：Antibiotic resistance, especially in multidrug-resistant ESKAPE pathogens, remains a worldwide problem. Combination antimicrobial therapies may be an important strategy to overcome resistance and broaden the spectrum of existing antibiotics. However, this strategy is limited by the ability to efficiently screen large combinatorial chemical spaces. Here, we deployed a high-throughput combinatorial screening platform, DropArray, to evaluate the interactions of over 30,000 compounds with up to 22...
• Supporting Information for Schmidt et al., Archaeological adhesives made from Podocarpus document innovative potential in the African Middle Stone Age (vol 119,e2209592119,2022) AI翻译
  作者：Schmidt, Patrick; Koch, Tabea J.; February, Edmund
• Linear Recursive Feature Machines provably recover low-rank matrices AI翻译
  作者：Radhakrishnan, Adityanarayanan; Belkin, Mikhail; Drusvyatskiy, Dmitriy
  作者单位：Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California San Diego; University of Washington; University of Washington Seattle
  摘要：A fundamental problem in machine learning is to understand how neural networks make accurate predictions, while seemingly bypassing the curse of dimensionality. A possible explanation is that common training algorithms for neural networks implicitly perform dimensionality reduction-a process called feature learning. Recent work [A. Radhakrishnan, D. Beaglehole, P. Pandit, M. Belkin, Science 383, 1461-1467 (2024).] posited that the effects of feature learning can be elicited from a classical st...
• Reply to Wang: Improving large language model approaches for identifying social determinants of health from clinical notes AI翻译
  作者：Gabriel, Rodney A.
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego
• Matrix degradation enhances stress relaxation, regulating cell adhesion and spreading AI翻译
  作者：Narasimhan, Badri Narayanan; Fraley, Stephanie I.
  作者单位：University of California System; University of California San Diego
  摘要：In native extracellular matrices (ECM), cells utilize matrix metalloproteinases (MMPs) to degrade and remodel their microenvironment. Accordingly, synthetic matrices have been engineered to permit MMP-mediated cleavage, facilitating cell spreading, migration, and interactions. However, the interplay between matrix degradability and mechanical properties remains underexplored. We hypothesized that MMP activity induces immediate mechanical alterations in the ECM, which are subsequently detected ...
• Competition response of cloud supersaturation explains diminished Twomey effect for smoky aerosol in the tropical Atlantic AI翻译
  作者：Dedrick, Jeramy L.; Pelayo, Christian N.; Russell, Lynn M.; Lubin, Dan; Muelmenstaedt, Johannes; Miller, Mark
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Rutgers University System; Rutgers University New Brunswick
  摘要：The Twomey effect brightens clouds by increasing aerosol concentrations, which activates more droplets and decreases cloud supersaturation in response to more competition for water vapor. To quantify this competition response, we used marine low cloud observations in clean and smoky conditions at Ascension Island in the tropical South Atlantic during the Layered Aerosol Smoke Interactions with Cloud (LASIC) campaign. These observations show similar increases in droplet number for increased acc...
• The emergence of eukaryotes as an evolutionary algorithmic phase transition AI翻译
  作者：Muro, Enrique M.; Ballesteros, Fernando J.; Luque, Bartolo; Bascompte, Jordi
  作者单位：Johannes Gutenberg University of Mainz; University of Valencia; Universidad Politecnica de Madrid; University of Zurich
  摘要：The origin of eukaryotes represents one of the most significant events in evolution since it allowed the posterior emergence of multicellular organisms. Yet, it remains unclear how existing regulatory mechanisms of gene activity were transformed to allow this increase in complexity. Here, we address this question by analyzing the length distribution of proteins and their corresponding genes for 6,519 species across the tree of life. We find a scale-invariant relationship between gene mean leng...
• Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes AI翻译
  作者：Sierant, Michael C.; Jin, Sheng Chih; Bilguvar, Kaya; Morton, Sarah U.; Dong, Weilai; Jiang, Wei; Lu, Ziyu; Li, Boyang; Lopez-Giraldez, Francesc; Tikhonova, Irina; Zeng, Xue; Lu, Qiongshi; Choi, Jungmin; Zhang, Junhui; Nelson-Williams, Carol; Knight, James R.; Zhao, Hongyu; Cao, Junyue; Mane, Shrikant; Sedore, Stanley C.; Gruber, Peter J.; Lek, Monkol; Goldmuntz, Elizabeth; Deanfield, John; Giardini, Alessandro; Mital, Seema; Russell, Mark; Gaynor, J. William; King, Eileen; Wagner, Michael; Srivastava, Deepak; Shen, Yufeng; Bernstein, Daniel; Porter Jr, George A.; Newburger, Jane W.; Seidman, Jonathan G.; Roberts, Amy E.; Yandell, Mark; Yost, H. Joseph; Tristani-Firouzi, Martin; Kim, Richard; Chung, Wendy K.; Gelb, Bruce D.; Seidman, Christine E.; Brueckner, Martina; Lifton, Richard P.
  作者单位：Yale University; Rockefeller University; Washington University (WUSTL); Washington University (WUSTL); Yale University; Yale University; Yale University; Acibadem University; Acibadem University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Yale University; Rockefeller University; University of Wisconsin System; University of Wisconsin Madison; Korea University; Korea University Medicine (KU Medicine); Yale University; Michigan State University; Michigan State University College of Human Medicine; Yale University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of London; University College London; University of London; University College London; Great Ormond Street Hospital for Children NHS Foundation Trust; University of Toronto; Hospital for Sick Children (SickKids); University of Michigan System; University of Michigan; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; Stanford University; Stanford Medicine; University of Rochester; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Utah System of Higher Education; University of Utah; Catholic University of America; Utah System of Higher Education; University of Utah; Cedars Sinai Medical Center; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Columbia University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute
  摘要：Congenital heart disease (CHD) is a leading cause of infant mortality. We analyzed de novo mutations (DNMs) and very rare transmitted/unphased damaging variants in 248 prespecified genes in 11,555 CHD probands. The results identified 60 genes with a significant burden of heterozygous damaging variants. Variants in these genes accounted for CHD in 10.1% of probands with similar contributions from de novo and transmitted variants in parent-offspring trios that showed incomplete penetrance. DNMs ...