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作者：Goncalves, Monica M.; Uday, Adwaith B.; Forrester, Taylor J. B.; Currie, S. Quinn W.; Kim, Angelina S.; Feng, Yue; Jitkova, Yulia; Velyvis, Algirdas; Harkness, Robert W.; Kimber, Matthew S.; Schimmer, Aaron D.; Zeytuni, Natalie; Vahidi, Siavash
作者单位：University of Guelph; McGill University; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; McGill University
摘要：Human ClpP protease contributes to mitochondrial protein quality control by degrading misfolded proteins. ClpP is overexpressed in cancers such as acute myeloid leukemia (AML), where its inhibition leads to the accumulation of damaged respiratory chain subunits and cell death. Conversely, hyperactivating ClpP with small- molecule activators, such as the recently discovered ONC201, disrupts mitochondrial protein degradation and impairs respiration in cancer cells. Despite its critical role in h...
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作者：Tili, Esmerina; Commisso, Teresa L.; Balatti, Veronica; Michaille, Jean - Jacques; Nuovo, Gerard J.; Croce, Carlo M.
作者单位：University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University
摘要：Elevated miR-155 levels in B cell malignancies, such as CLL and DLBCL, correlate with increased aggressiveness of the disease. We recently reported that, in two different mouse models of miR-155-driven B cell malignancy, miR-155 targets and down-regulates transcripts encoding ICOSL, the ligand for the Inducible T cell costimulator (ICOS), thereby impairing the capacity of T lymphocytes to recognize and eliminate malignant cells. In report, we extend our previous findings to Human by showing th...
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作者：Kerig, Tim; Crema, Enrico R.; Birch, Jennifer; Feinman, Gary M.; Green, Adam S.; Gronenborn, Detlef; Lawrence, Dan; Petrie, Cameron A.; Roscoe, Paul; Thompson, Amy E.; Kohler, Timothy A.
作者单位：University of Kiel; Leipzig University; University of Cambridge; University System of Georgia; University of Georgia; Field Museum of Natural History (Chicago); University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of York - UK; University of York - UK; Durham University; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono; University of Texas System; University of Texas Austin; Washington State University; The Santa Fe Institute
摘要：From Rousseau onward, scholars have identified the transition to sedentary agriculture as crucial to the history of wealth inequality. Here, using the GINI project's global database on disparities in residential size, we examine the effects of important innovations in plant cultivation, animal husbandry, and traction on wealth inequality. Over a series of regional case studies, we find no evidence of major changes in residential disparity before or after these technological innovations became ...
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作者：Feinman, Gary M.; Quequezana, Gabriela Cervantes; Green, Adam; Lawrence, Dan; Munson, Jessica; Ortman, Scott; Petrie, Cameron; Thompson, Amy; Nicholas, Linda M.
作者单位：Field Museum of Natural History (Chicago); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of York - UK; University of York - UK; Durham University; University of Colorado System; University of Colorado Boulder; University of Cambridge; University of Texas System; University of Texas Austin
摘要：Long-entrenched grand narratives have tied inequality in large human aggregations to generally linear trends, a direct outcome of domestication, then fostered by population growth and/or stepped scalar transitions in the hierarchical complexity of human institutions. This general pattern has been argued to short-circuit or reverse only in the context of cataclysmic disasters or societal breakdowns. Yet, for the most part, these universal deterministic frameworks have been constructed from hist...
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作者：Hoes, Emma; Gilardi, Fabrizio
作者单位：University of Zurich
摘要：There is broad consensus that AI presents risks, but considerable disagreement about the nature of those risks. These differing viewpoints can be understood as distinct narratives, each offering a specific interpretation of AI's potential dangers. One narrative focuses on doomsday predictions of AI posing long-term existential risks for humanity. Another narrative prioritizes immediate concerns that AI brings to society today, such as the reproduction of biases embedded into AI systems. A sign...
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作者：Ma, Ya; Zhang, Zhuyi; Cao, Xiaolian; Guo, Dianlei; Huang, Shuting; Xie, Lijing; Wu, Mingjuan; Li, Junru; Li, Chenxin; Chu, Yu; Jiang, Shuxin; Hao, Yu; Wang, Can; Zhong, Xiali; Ju, Rong; Zhang, Feng; Liu, Chunqiao; Wei, Yanhong
作者单位：Sun Yat Sen University; Sun Yat Sen University
摘要：Ischemic retinal diseases are major causes of blindness worldwide and are characterized by pathological angiogenesis. Epigenetic alterations in response to metabolic shifts in and its subsequent histone lactylation in ECs contribute to vascular disorders. However, the regulatory mechanism of establishing and sustaining lactylation modification remains elusive. Here, we showed that lactate accumulation induced histone lactylations on H3K9 and H3K18 in neovascular ECs in the proliferative stage ...
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作者：Crema, Enrico R.; Fochesato, Mattia; Ramon, Andres G. Mejia; Munson, Jessica; Ortman, Scott G.
作者单位：University of Cambridge; University of Cambridge; Bocconi University; Bocconi University; Bocconi University; Centre for Economic Policy Research - UK; Okinawa Institute of Science & Technology Graduate University; Autonomous University of Barcelona; University of Colorado System; University of Colorado Boulder
摘要：The Gini coefficient is a statistical measure commonly used to characterize distributions of socioeconomic quantities. Archaeologists and social scientists have recently adopted this method to analyze ancient inequality by targeting specific proxy variables (e.g., residential unit size, burial data, etc.). Variations in the Gini are then examined in relation to key factors such as time, geography, and subsistence. Yet, Gini coefficients could be obtained across different scales of aggregation,...
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作者：Erickson, Andrea K.; Sutherland, Danica M.; Welsh, Olivia L.; Maples, Robert W.; Dermody, Terence S.; Pfeiffer, Julie K.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Many enteric viruses benefit from the microbiota. In mice, microbiota depletion reduces infection by noroviruses and picornaviruses. However, Reovirales viruses are outliers among enteric viruses. Rotavirus infection is inhibited by bacteria, and we determined that several reovirus strains have enhanced replication following microbiota depletion. Here, we focused on an isogenic pair of reoviruses that have opposing infection outcomes after microbiota depletion. Microbiota depletion reduces inf...
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作者：Huang, Yung-Hsin; Belk, Julia A.; Zhang, Ruochi; Weiser, Natasha E.; Chiang, Zachary; Jones, Matthew G.; Mischel, Paul S.; Buenrostro, Jason D.; Chang, Howard Y.
作者单位：Stanford University; Stanford Medicine; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Howard Hughes Medical Institute; Stanford University
摘要：Spatial epigenomics and multiomics can provide fine-grained insights into cellular states but their widespread adoption is limited by the requirement for bespoke slides and capture chemistries for each data modality. Here, we present SPatial assay for Accessible chromatin, Cell lineages, and gene Expression with sequencing (SPACE-seq), a method that utilizes polyadenine-tailed epigenomic libraries to enable facile spatial multiomics using standard whole transcriptome reagents. Applying SPACE-s...
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作者：Kohler, Timothy A.; Bogaard, Amy; Ortman, Scott G.; Crema, Enrico R.; Chirikure, Shadreck; Cruz, Pablo; Green, Adam; Kerig, Tim; Mccoy, Mark D.; Munson, Jessica; Petrie, Cameron; Thompson, Amy E.; Birch, Jennifer; Quequezana, Gabriela Cervantes; Feinman, Gary M.; Fochesato, Mattia; Gronenborn, Detlef; Hamerow, Helena; Jin, Guiyun; Lawrence, Dan; Roscoe, Paul B.; Rosenstock, Eva; Erny, Grace K.; Kim, Habeom; Ohlrau, Rene; Hanson, J. W.; Navarro, Lane Fargher; Pailes, Matthew
作者单位：Washington State University; The Santa Fe Institute; University of Oxford; University of Colorado System; University of Colorado Boulder; University of Cambridge; University of York - UK; University of York - UK; University of Kiel; Leipzig University; State University System of Florida; Florida State University; University of Texas System; University of Texas Austin; University System of Georgia; University of Georgia; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Field Museum of Natural History (Chicago); Bocconi University; Johannes Gutenberg University of Mainz; Shandong University; Durham University; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono; University of Bonn; University of California System; University of California Berkeley; University of Oxford; University System of Ohio; Ohio State University; University of Oklahoma System; University of Oklahoma - Norman
摘要：Defining wealth broadly to include wealth in people, relational connections, and material possessions, we examine the prehistory of wealth inequality at the level of the residential units using the consistent proxy of Gini coefficients calculated across areas of contemporaneous residential units. In a sample of >1,100 sites and > 47,000 residential units spanning >10,000 y, persistent wealth inequality typically lags the onset of plant cultivation by more than a millennium. It accompanies land...
