16期

最新文章

• Tearing down the house of mosquito- transmitted viruses AI翻译
  作者：Pandey, Shanti; Gack, Michaela U.
  作者单位：Cleveland Clinic Foundation
• European Neolithic farmers interbred their domestic pigs with wild boar AI翻译
  作者：Rowley-Conwy, Peter
  作者单位：Durham University
• Cleavage cascade of the sigma regulator FecR orchestrates TonB- dependent signal transduction AI翻译
  作者：Yokoyama, Tatsuhiko; Miyazaki, Ryoji; Suzuki, Takehiro; Dohmae, Naoshi; Nagai, Hiroki; Tsukazaki, Tomoya; Kubori, Tomoko; Akiyama, Yoshinori
  作者单位：Gifu University; Nara Institute of Science & Technology; RIKEN; Gifu University; Kyoto University
  摘要：TonB-dependent signal transduction is a versatile mechanism observed in gram-negative bacteria that integrates energy-dependent substrate transport with signal relay. In Escherichia coli, the TonB-ExbBD motor complex energizes the TonB-dependent outer membrane transporter FecA, facilitating ferric citrate import. FecA also acts as a sensor, transmitting signals to the cytoplasmic membrane protein FecR, which eventually activates the cytoplasmic sigma factor FecI, driving transcription of the f...
• Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury AI翻译
  作者：Bongoni, Anjan K.; Kiss, Bence; McRae, Jennifer L.; Salvaris, Evelyn J.; Fisicaro, Nella; Muntz, Fenella; Nemeth, Balint Zoltan; Nagy, Zoltan Attila; Kocsis, Andrea; Gal, Peter; Cowan, Peter J.; Pal, Gabor
  作者单位：St Vincent's Health; St Vincent's Hospital Melbourne; Eotvos Lorand University; St Vincent's Health; St Vincent's Hospital Melbourne; HUN-REN; HUN-REN Research Centre for Natural Sciences; University of Melbourne
  摘要：Renal ischemia-reperfusion injury (IRI) is a common complication in several clinical scenarios including kidney transplantation. Mannan-binding lectin-associated serine proteinase (MASP)-2 is essential for activation of the complement lectin pathway, which has been implicated in the pathogenesis of renal IRI and therefore represents a potential therapeutic target. We developed a new, affinity-enhanced MASP-2 inhibitor, EVO24, by directed evolution of the D2 domain of human tissue factor pathwa...
• Exotic mechanical properties enabled by countersnapping instabilities AI翻译
  作者：Ducarme, Paul; Weber, Bart; van Hecke, Martin; Overvelde, Johannes T. B.
  作者单位：AMOLF; AMOLF; University of Amsterdam; Leiden University - Excl LUMC; Leiden University; Eindhoven University of Technology
  摘要：Mechanical snapping instabilities are leveraged by natural systems, metamaterials, and devices for rapid sensing, actuation, and shape changes, as well as to absorb impact. In all current forms of snapping, shapes deform in the same direction as the exerted forces, even though there is no physical law that dictates this. Here, we realize countersnapping mechanical structures that respond in the opposite way. In contrast to regular snapping, countersnapping manifests itself in a sudden shorteni...
• Dynamics of two distinct memory interactions during water seeking in Drosophila AI翻译
  作者：Lee, Wang - Pao; Chiang, Meng- Hsuan; Chao, Yi- Ping; Wang, Ying- Fong; Chen, Yan- Lin; Lin, Yu - Chun; Jenq, Shan- Yun; Lu, Jun - Wei; Fu, Tsai- Feng; Liang, Jia- Yu; Yang, Kai- Cing; Chang, Li- Yun; Wu, Tony; Wu, Chia - Lin
  作者单位：Chang Gung University; Chang Gung University; Chang Gung University; National Tsing Hua University; Chang Gung University; National Chi Nan University; Chang Gung Memorial Hospital
  摘要：Forming and forgetting memories shape our self- awareness and help us face future challenges. Therefore, understanding how memories are formed and how different memories interact in the brain is important. Previous studies have shown that thirsty flies sense humidity through ionotropic receptors, which help them locate water sources. Here, we showed that thirsty flies can be trained to associate specific odors with humidity to form a humidity memory that lasts for 30 min after association. Hum...
• Pulse timing dominates binaural hearing with cochlear implants AI翻译
  作者：Schnupp, Jan W. H.; Buchholz, Sarah; Buck, Alexa N.; Budig, Henrike; Khurana, Lakshay; Rosskothen-Kuhl, Nicole
  作者单位：City University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; University of Freiburg; University of Freiburg; University of Freiburg
  摘要：Although cochlear implants (CIs) provide valuable auditory information to more than one million profoundly deaf patients, these devices remain inadequate in conveying fine timing cues. Early deaf patients in particular struggle to use interaural time differences (ITDs) for spatial hearing and auditory scene analysis. Why CI patients experience these limitations remains controversial. One possible explanation, which we investigate here, is that the stimulation by clinical CIs is inappropriate, ...
• Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling (vol 122, e2417252121, 2025) AI翻译
  作者：Yardeni, Tal; Olali, Arnold Z.; Chen, Hsiao-Wen; Wang, Liqing; Halton, Jeffrey A.; Zenab, Angi; Morrow, Ryan; Butic, Arrienne; Murdock, Deborah G.; Waymire, Katrina G.; MacGregor, Grant R.; Boursi, Ben; Beier, Ulf H.; Hancock, Wayne W.; Wallace, Douglas C.
• Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity AI翻译
  作者：Fountain, Adam J.; Waller, Natalie J. E.; Cheung, Chen - Yi; Jowsey, William; Chrisp, Michael T.; Troll, Mark; Edelstein, Paul H.; Cook, Gregory M.; Mcneil, Matthew B.; Ramakrishnan, Lalita
  作者单位：MRC Laboratory Molecular Biology; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of Otago; Queensland University of Technology (QUT)
  摘要：Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant tuberculosis. However, its clinical use is threatened by the emergence of bedaquiline-resistant strains of Mycobacterium tuberculosis. Bedaquiline targets mycobacterial ATP synthase but the predominant route to clinical bedaquiline resistance is via upregulation of the MmpS5L5 efflux pump due to mutations that inactivate the transcriptional repressor Rv0678. Here, we show that the MmpS5L5 efflux pump reduces su...
• Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination AI翻译
  作者：Staples, Sabrina C. R.; Yin, Hao; Sutherland, Frances S. K.; Prescott, Emma K.; Tinney, Dylan; Hamilton, Douglas W.; Goldman, Daniel; Poepping, Tamie L.; Ellis, Christopher G.; Pickering, J. Geoffrey
  作者单位：Western University (University of Western Ontario); University Western Ontario Hospital; Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario); London Health Sciences Centre
  摘要：Intussusceptive angiogenesis is an increasingly recognized vessel duplication process that generates and reshapes microvascular beds. However, the mechanism by which a vessel splits into two is poorly understood. Particularly vexing is formation of the hallmark transluminal endothelial cell bridge. How an endothelial cell comes to cross a flowing lumen rather than line it is enigmatic. To elucidate this, we used a microvessel-on-a-chip strategy, creating a microconduit coherently lined with fl...